Available online 10 February 2023

A fifty-three-year-old woman was referred to ocular oncology for a melanocytic lesion of the left iris (Fig. 1A). She reported a longstanding pigmented iris nevus in the left eye for ten years which had increased in size recently. She had no other past medical history. Anterior segment examination revealed a small amelanotic lesion close to the iris margin with a pigmented base, measuring 0.5 mm in thickness over 2.7 mm in diameter on ultrasound biomicroscopy (UBM). The clinical aspect was

Ocular syphilis is known to mimic a variety of eye diseases and has even been termed “the great masquerader”. The question in this case is whether the iris lesion was an iris melanoma as initially thought, or a rare iris nodule associated with syphilis. The ABCDEF rule has been shown to predict the risk of growth for iris nevi which is helpful in deciding which lesions should be treated as melanoma (Age ≤ 40 years, Blood in the anterior chamber, Clock-hour inferior, Diffuse configuration,

The authors declare that they have no competing interest.

There are more references available in the full text version of this article.

© 2023 Elsevier Masson SAS. All rights reserved.