I am grateful to K. Basler for immense support, G. Hausmann for valuable comments on the manuscript, M. D. Brügger for technical assistance with the figure and other members of the Basler laboratory for discussions and feedbacks. My work was supported by the Forschungskredit of the University of Zürich grant FK-21-119 and a grant of the University and Medical Faculty of Zurich and the Comprehensive Cancer Center Zurich.