Zhou JH, Wang XT, Zhou L, Zhou L, Xu FX, Su LD, Wang H, Jia F, Xu FQ, Chen GQ, De Zeeuw CI, Shen Y. Ablation of TFR1 in Purkinje cells inhibits mGlu1 trafficking and impairs motor coordination, but not autistic-like behaviors. J Neurosci. 2017;37(47):11335–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou L, Yang D, Wang DJ, Xie YJ, Zhou JH, Zhou L, Huang H, Han S, Shao CY, Li HS, Zhu JJ, Qiu MS, De Zeeuw CI, Shen Y. Numb deficiency in cerebellar Purkinje cells impairs synaptic expression of metabotropic glutamate receptor and motor coordination. Proc Natl Acad Sci U S A. 2015;112(50):15474–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang SS, Kloth AD, Badura A. The cerebellum, sensitive periods, and autism. Neuron. 2014;83(3):518–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koziol LF, Budding D, Andreasen N, D’Arrigo S, Bulgheroni S, Imamizu H, Ito M, Manto M, Marvel C, Parker K, Pezzulo G, Ramnani N, Riva D, Schmahmann J, Vandervert L, Yamazaki T. Consensus paper: the cerebellum’s role in movement and cognition. Cerebellum. 2014;13(1):151–77.

Article  PubMed  PubMed Central  Google Scholar 

Strick PL, Dum RP, Fiez JA. Cerebellum and nonmotor function. Annu Rev Neurosci. 2009;32:413–34.

Article  CAS  PubMed  Google Scholar 

Fikry H, Saleh LA, Abdel GS. Neuroprotective effects of curcumin on the cerebellum in a rotenone-induced Parkinson’s disease model. CNS Neurosci Ther. 2022;28(5):732–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bonthius DJ. Ataxia and the cerebellum. Semin Pediatr Neurol. 2011;18(2):69–71.

Article  PubMed  Google Scholar 

ten Donkelaar HJ, Lammens M, Wesseling P, Thijssen HO, Renier WO. Development and developmental disorders of the human cerebellum. J Neurol. 2003;250(9):1025–36.

Article  PubMed  Google Scholar 

Hibi M, Shimizu T. Development of the cerebellum and cerebellar neural circuits. Dev Neurobiol. 2012;72(3):282–301.

Article  PubMed  Google Scholar 

Yang H, Zhu Q, Cheng J, Wu Y, Fan M, Zhang J, Wu H. Opposite regulation of Wnt/beta-catenin and Shh signaling pathways by Rack1 controls mammalian cerebellar development. Proc Natl Acad Sci U S A. 2019;116(10):4661–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang VY, Zoghbi HY. Genetic regulation of cerebellar development. Nat Rev Neurosci. 2001;2(7):484–91.

Article  CAS  PubMed  Google Scholar 

Li Y, Yang C, Wang H, Zhao L, Kong Q, Cang Y, Zhao S, Lv L, Li Y, Mao B, Ma P. Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression. J Mol Cell Biol. 2022; 14(1).

Peng J, Sheng A-L, Xiao Q, Shen L, Ju X-C, Zhang M, He S-T, Wu C, Luo Z-G. Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum. J Mol Cell Biol. 2019;11(8):636–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang M, Casey PJ. Protein prenylation: unique fats make their mark on biology. Nat Rev Mol Cell Biol. 2016;17(2):110–22.

Article  CAS  PubMed  Google Scholar 

Salaun C, Greaves J, Chamberlain LH. The intracellular dynamic of protein palmitoylation. J Cell Biol. 2010;191(7):1229–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Palsuledesai CC, Distefano MD. Protein prenylation: enzymes, therapeutics, and biotechnology applications. ACS Chem Biol. 2015;10(1):51–62.

Article  CAS  PubMed  Google Scholar 

Maurer-Stroh S, Washietl S, Eisenhaber F. Protein prenyltransferases. Genome Biol. 2003;4(4):212.

Article  PubMed  PubMed Central  Google Scholar 

Zhang FL, Casey PJ. Protein prenylation: molecular mechanisms and functional consequences. Annu Rev Biochem. 1996;65:241–69.

Article  CAS  PubMed  Google Scholar 

Afshordel S, Kern B, Clasohm J, Konig H, Priester M, Weissenberger J, Kogel D, Eckert GP. Lovastatin and perillyl alcohol inhibit glioma cell invasion, migration, and proliferation? Impact of Ras-/Rho-prenylation Pharmacol Res. 2015;91:69–77.

CAS  PubMed  Google Scholar 

Berndt N, Hamilton AD, Sebti SM. Targeting protein prenylation for cancer therapy. Nat Rev Cancer. 2011;11(11):775–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McTaggart SJ. Isoprenylated proteins. Cell Mol Life Sci. 2006;63(3):255–67.

Article  CAS  PubMed  Google Scholar 

Theofilas P, Piergies AMH, Oh I, Lee YB, Li SH, Pereira FL, Petersen C, Ehrenberg AJ, Eser RA, Ambrose AJ, Chin B, Yang T, Khan S, Ng R, Spina S, Seeley WW, Miller BL, Arkin MR, Grinberg LT. Caspase-6-cleaved tau is relevant in Alzheimer’s disease and marginal in four-repeat tauopathies: diagnostic and therapeutic implications. Neuropathol Applied Neurobiol. 2022;48(5): e12819.

Article  CAS  Google Scholar 

Xie H, Yang X, Cao Y, Long X, Shang H, Jia Z. Role of lipoic acid in multiple sclerosis. CNS Neurosci Ther. 2021;28(3):319–31.

Article  PubMed  PubMed Central  Google Scholar 

Kurz C, Walker L, Rauchmann B-S, Perneczky R. Dysfunction of the blood nrain barrier in Alzheimer’s disease: evidence from human studies. Neuropathol Applied Neurobiol. 2021;48(3): e12782.

Google Scholar 

Schon EA, Przedborski S. Mitochondria: the next (neurode)generation. Neuron. 2011;70(6):1033–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qi W, Yan L, Liu Y, Zhou X, Li R, Wang Y, Bai L, Chen J, Nie X. Simvastatin aggravates impaired autophagic flux in NSC34-hSOD1G93A cells through inhibition of geranylgeranyl pyrophosphate synthesis. Neuroscience. 2019;409:130–41.

Article  CAS  PubMed  Google Scholar 

Jeong A, Suazo KF, Wood WG, Distefano MD, Li L. Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer’s disease. Crit Rev Biochem Mol Biol. 2018;53(3):279–310.

Article  PubMed  PubMed Central  Google Scholar 

Stoodley CJ. The cerebellum and neurodevelopmental disorders. Cerebellum. 2016;15(1):34–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao S, Yu R, Zhou X. The role of geranylgeranyltransferase 1-mediated protein prenylation in the brain. Mol Neurobiol. 2016;53(10):6925–37.

Article  CAS  PubMed  Google Scholar 

Marschalek N, Albert F, Afshordel S, Meske V, Eckert GP, Ohm TG. Geranylgeranyl pyrophosphate is crucial for neuronal survival but has no special role in Purkinje cell degeneration in Niemann Pick type C1 disease. J Neurochem. 2015;133(1):153–61.

Article  CAS  PubMed  Google Scholar 

Hottman D, Cheng S, Gram A, LeBlanc K, Yuan LL, Li L. Systemic or forebrain neuron-specific deficiency of geranylgeranyltransferase-1 impairs synaptic plasticity and reduces dendritic spine density. Neuroscience. 2018;373:207–17.

Article  CAS  PubMed  Google Scholar 

Zhou XP, Wu KY, Liang B, Fu XQ, Luo ZG. TrkB-mediated activation of geranylgeranyltransferase 1 promotes dendritic morphogenesis. Proc Natl Acad Sci U S A. 2008;105(44):17181–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu K-Y, Zhou X-P, Luo Z-G. Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells. Mol Brain. 2010;3(1):18.

Article  PubMed  PubMed Central  Google Scholar 

Zhuo L, Theis M, Alvarez-Maya I, Brenner M, Willecke K, Messing A. hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis. 2001;31(2):85–94.

Article  CAS  PubMed  Google Scholar 

Xia Y, Zhang Y, Xu M, Zou X, Gao J, Ji MH, Chen G. Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but into not basal progenitors in the developing hippocampus. Development. 2022; 149(10).

Cheng S, Liu T, Hu Y, Xia Y, Hou J, Huang C, Zou X, Liang J, Stone Shi Y, Zheng Y, Lu J, Chen G. Conditional inactivation of Pen-2 in the developing neocortex leads to rapid switch of apical progenitors to basal progenitors. J Neurosci. 2019;39(12):2195–207.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Zhao M-F, Jiang S, Wu J, Liu J, Yuan X-W, Shen D, Zhang J-Z, Zhou N, He J, Fang L, Sun X-T, Xue B, Li C-J. Liver governs adipose remodelling via extracellular vesicles in response to lipid overload. Nat Commun. 2020;11(1):719.

Article  CAS  PubMed  PubMed Central