Response to: The difference in the association between included ECPR patients and neurological outcomes

We express our gratitude to Hifumi and their associates for their interest in our manuscript pertaining to the utilization of targeted temperature management (TTM) among patients treated with extracorporeal membrane oxygenation (ECMO) [1].

As noted, the optimal target temperature may vary contingent upon the aetiology of arrest. While 91% of our study cohort had a cardiac cause of arrest, the impact of the remaining patients on the outcome of our study may be non-negligible. Therefore, we conducted a sensitivity analysis that included only the patients with a cardiac cause of arrest and found the results to be consistent (see Table 1).

Table 1 Sensitivity analysis (including only the patients with a cardiac cause of arrest)

We concur that there may be an inherent bias, specifically “physician’s discretion”. As Hifumi and colleagues have astutely pointed out, critically ill patients may tend to be treated with higher targeted temperatures. However, we contend that this study possesses a certain degree of robustness as we adjusted for numerous pre- and in-hospital factors that physicians commonly consider when determining target temperature, such as the cause of cardiac arrest, initial documented rhythm at the scene and upon hospital arrival, and time-related variables. Nevertheless, we agree that validation of our findings necessitates an evaluation of the Study of Advanced Life Support for Ventricular Fibrillation with Extracorporeal Circulation in Japan (SAVE-J II) trial, a comprehensive observational study on the same topic that utilizes detailed treatment-related data [2], as well as a meta-analysis. Furthermore, a randomized controlled trial is imperative to determine the optimal target temperature for patients undergoing ECMO.

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