Liu J (2005) Oleanolic acid and ursolic acid: research perspectives. J Ethnopharmacol 100:92–94. https://doi.org/10.1016/j.jep.2005.05.024

Article  CAS  PubMed  Google Scholar 

Shukla B, Visen PKS, Patnaik GK, Tripathi SC, Srimal RC, Dayal R, Dobhal PC (1992) Hepatoprotective activity in the rat of ursolic acid isolated from eucalyptus hybrid. Phytother Res 6:74–79. https://doi.org/10.1002/ptr.2650060205

Article  CAS  Google Scholar 

Sun Q, He M, Zhang M, Zeng S, Chen L, Zhou L, Xu H (2020) Ursolic acid: a systematic review of its pharmacology, toxicity and rethink on its pharmacokinetics based on PK-PD model. Fitoterapia 147:104735. https://doi.org/10.1016/j.fitote.2020.104735

Article  CAS  PubMed  Google Scholar 

Baricevic D, Sosa S, Loggia RD, Tubaro A, Simonovska B, Krasna A, Zupancic A (2001) Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid. J Ethnopharmacol 75:125–132. https://doi.org/10.1016/S0378-8741(00)00396-2

Article  CAS  PubMed  Google Scholar 

Liu J (1995) Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 49:57–68. https://doi.org/10.1016/0378-8741(95)90032-2

Article  CAS  PubMed  Google Scholar 

Ma CM, Cai SQ, Cui JR, Wang RQ, Tu PF, Hattori M, Daneshtalab M (2005) The cytotoxic activity of ursolic acid derivatives. Eur J Med Chem 40:582–589. https://doi.org/10.1016/j.ejmech.2005.01.001

Article  CAS  PubMed  Google Scholar 

Li J, Guo WJ, Yang QY (2002) Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15. World J Gastroenterol 8:493–495. https://doi.org/10.3748/wjg.v8.i3.493

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farina C, Pinza M, Pifferi G (1998) Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic, oleanolic and ursolic acids. Il Farmaco 53:22–32. https://doi.org/10.1016/S0014-827X(97)00013-X

Article  CAS  PubMed  Google Scholar 

Gnoatto SCB, Alexandra DK, Nascimento SD, Galera P, Boumediene K, Gosmann G, Sonnet P, Moslemi S (2008) Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition. Eur J Med Chem 43:1865–1877. https://doi.org/10.1016/j.ejmech.2007.11.021

Article  CAS  PubMed  Google Scholar 

Liu Y, Hartley DP, Liu J (1998) Protection against carbon tetrachloride hepatotoxicity by oleanolic acid is not mediated through metallothionein. Toxicol Lett 95:77–85. https://doi.org/10.1016/S0378-4274(98)00009-5

Article  CAS  PubMed  Google Scholar 

Zhou XJ, Hu XM, Yi YM, Wan J (2009) Preparation and body distribution of freeze-dried powder of ursolic acid phospholipid nanoparticles. Drug Dev Ind Pharm 35:305–310. https://doi.org/10.1080/03639040802302165

Article  CAS  PubMed  Google Scholar 

Zuvela P, Skoczylas M, Liu JJ, Baczek T, Kaliszan R, Wong MW, Buszewski B (2019) Column characterization and selection systems in reversed-phase high-performance liquid chromatography. Chem Rev 119:3674–3729. https://doi.org/10.1021/acs.chemrev.8b00246

Article  CAS  PubMed  Google Scholar 

Song M, Hang T, Wang Y, Jiang L, Wu X, Zhang Z, Shen J, Zhang YJ (2006) Determination of oleanolic acid in human plasma and study of its pharmacokinetics in Chinese healthy male volunteers by HPLC tandem mass spectrometry. J Pharm Biomed Anal 40:190–196. https://doi.org/10.1016/j.jpba.2005.06.034

Article  CAS  PubMed  Google Scholar 

Gbaguidi F, Accrombessi G, Moudachirou MJ, Quetin-Leclercq J (2005) HPLC quantification of two isomeric triterpenic acids isolated from Mitracarpus scaber and antimicrobial activity on Dermatophilus congolensis. J Pharm Biomed Anal 39:990–995. https://doi.org/10.1016/j.jpba.2005.05.030

Article  CAS  PubMed  Google Scholar 

Chen JH, Xia ZH, Tan RX (2003) High-performance liquid chromatographic analysis of bioactive triterpenes in Perilla frutescens. J Pharm Biomed Anal 32:1175–1179. https://doi.org/10.1016/S0731-7085(03)00160-2

Article  CAS  PubMed  Google Scholar 

Buchele B, Zugmaier W, Simmet T (2003) Analysis of pentacyclic triterpenic acids from frankincense gum resins and related phytopharmaceuticals by high-performance liquid chromatography. Identification of lupeolic acid, a novel pentacyclic triterpene. J Chromatogr B 791:21–30. https://doi.org/10.1016/S1570-0232(03)00160-0

Article  CAS  Google Scholar 

Claude B, Morin P, Lafosse M, Andre P (2004) Evaluation of apparent formation constants of pentacyclic triterpene acids complexes with derivatized β- and γ-cyclodextrins by reversed phase liquid chromatography. J Chromatogr A 1049:37–42. https://doi.org/10.1016/j.chroma.2004.06.133

Article  CAS  PubMed  Google Scholar 

Monte FJQ, Kintzinger JP, Trendel JM, Poinsot J (1997) Mixture of closely related isomeric triterpenoid derivatives: Separation and purification by reversed-phase high-performance liquid chromatography. Chromatographia 46:251–255. https://doi.org/10.1007/BF02496315

Article  CAS  Google Scholar 

Liao LP, Li SL, Li P (2005) Simultaneous determination of seven triterpenoids and triterpenoid saponins in Folium Ilicis Purpureae by high performance liquid chromatography coupled with evaporative light scattering detection. J Separ Sci 28:2061–2066. https://doi.org/10.1002/jssc.200500136

Article  CAS  Google Scholar 

Lacikova L, Abdel-Hamid ME, Novotny L, Masterova I, Grancai D (2006) A rapid tandem mass spectrometric assay for determination of ursolic acid—application to analysis of ursolic acid in four species of Staphylea L. and Leaves of Staphylea Pinnata L. Gathered during ontogenesis. Chromatographia 63:117–122. https://doi.org/10.1365/s10337-006-0724-y

Article  CAS  Google Scholar 

Novotny L, Abdel-Hamid ME, Hamza H, Masterova I, Grancai D (2003) Development of LC–MS method for determination of ursolic acid: application to the analysis of ursolic acid in Staphylea holocarpa Hemsl. J Pharm Biomed Anal 31:961–968. https://doi.org/10.1016/S0731-7085(02)00706-9

Article  CAS  PubMed  Google Scholar 

Janicsak G, Veres K, Kakasy AZ, Mathe I (2006) Study of the oleanolic and ursolic acid contents of some species of the Lamiaceae. Biochem Syst Ecol 34:392–396. https://doi.org/10.1016/j.bse.2005.12.004

Article  CAS  Google Scholar 

Li X, Wang Q, Zhang X, Sheng X, Zhou Y, Li M, Jing X, Li D, Zhang L (2007) HPLC study of pharmacokinetics and tissue distribution of morroniside in rats. J Pharm Biomed Anal 45:349–355. https://doi.org/10.1016/j.jpba.2007.05.013

Article  CAS  PubMed  Google Scholar 

Shetty PG, Mangaonkar KV, Sane RT, Jaripatke KK, Singh S (2007) Pharmacokinetic analysis of ursolic acid in Alstonia scholaris R. Br. by high-performance thin-layer chromatography. JPC-J Planar Chromat 20:117–120. https://doi.org/10.1556/JPC.20.2007.2.8

Article  CAS  Google Scholar 

Shetty P, Mangaonkar K, Sane RT (2007) HPTLC Determination of ursolic acid in Alstonia scholaris R. Br JPC-J Planar Chromat 20:65–68. https://doi.org/10.1556/JPC.20.2007.1.11

Article  CAS  Google Scholar 

Kosior MW (2007) Separation and determination of closely related triterpenic acids by high performance thin-layer chromatography after iodine derivatization. J Pharm Biomed Anal 45:337–340. https://doi.org/10.1016/j.jpba.2007.05.011

Article  CAS  Google Scholar