Nanodelivery systems for cutaneous melanoma treatment

5-ALA

5-Aminolevulinic Acid

5hmC

5-Hydroxymethylcytosine

AIDS

Acquired Immune Deficiency Syndrome

AJCC

American Joint Committee on Cancer

APC

Antigen-presenting Cells

API

Active Pharmaceutical Ingredient

ATP

Adenosine Triphosphate

BAP1

BRCA1-associated Protein 1

Bax

Bcl-2-associated X Protein

Bcl-xL

B-cell lymphoma-extra Large

BMDC

Bone Marrow-derived Dendritic Cell

BRAF

v-raf Murine Sarcoma Viral Oncogene Homolog B1- B-Raf Proto-oncogene, Serine/threonine Kinase

cAMP

Cyclic Adenosine Monophosphate

CAP

Cold Atmospheric Plasma

CD133

Cluster of Differentiation 133

CD44

Cluster of Differentiation 44

CD8

Cluster of Differentiation 8

CDK

Cyclin-dependent Kinase

CDKN2A

Cyclin-dependent Kinase Inhibitor 2A

c-MET

Hepatocyte Growth Factor Receptor

CONP

Cuprous Oxide Nanoparticle

CSCD

Chondroitin Sulfate-ss-deoxycholic Acid

CTC

Circulating Tumor Cell

CTL

Cytotoxic T Lymphocyte

CTLA-4

Cytotoxic T-lymphocyte-associated Protein-4

DLS

Dynamic Light Scattering

EDC

N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide Hydrochloride

EE

Encapsulation Efficiency

EGCG

Epigallocatechin-3-gallate

EGFR

Epidermal Growth Factor Receptor

EMT

Epithelial–mesenchymal Transition

EPR

Enhanced Permeability and Retention

ERK

Extracellular Signal-regulated Kinase

EZH2

Enhancer of Zeste Homolog 2

FDA

Food and Drug Administration

FNA

Framework Nucleic Acid

GMP

Gemcitabine Monophosphate

GRGDG

Glycine-arginine-glycine-aspartic acid-glycine

GRGDS

Glycine-arginine-glycine-aspartic acid-serine

HPMC

Hydroxypropyl Methylcellulose

HUVEC

Human Umbilical Vein Endothelial Cell

IARC

International Agency for Research on Cancer

IC50

Half Inhibitory Concentration

irAE

Autoimmune-related Adverse Event

LCP

Lipid-coated Calcium-phosphate

LDH

Serum Lactate Dehydrogenase

LMM

Lentigo Maligna Melanoma

LZnP

Lipid-coated Zinc Phosphate

MAPK

Mitogen-activated Protein Kinase

MBCSP

Magnetic-based Core-shell Nanoparticle

MC1R

Melanocortin-1 Receptor

MDM2

Murine Double Minute 2

MDSC

Myeloid-derived Suppressor Cell

MHC

Major Histocompatibility Complex

MIA

Melanoma-inhibitory Activity

miRNA

Micro Ribonucleic Acid

MITF

Melanocyte Inducing Transcription Factor

mPEG

Methoxy Poly(ethylene glycol)

MPLA

Monophosphoryl lipid A

mRNA

Messenger Ribonucleic Acid

mTOR

Mammalian Target of Rapamycin

ncRNA

Non-coding Ribonucleic Acid

NEDD9

Neural Precursor Cell Expressed, Developmentally Down-regulated 9

NGFR

Nerve Growth Factor Receptor

NLC

Nanostructured lipid carrier

NMSC

Non-melanoma Skin Cancer

NPC

Neural Progenitor Cell

NRAS

Neuroblastoma RAS Viral Oncogene Homolog- NRAS Proto-oncogene, GTPase Proto-oncogene

PCL

Poly (ε-caprolactone)

PD-1

Programmed Cell Death Protein-1

PD-L1

Programmed Cell Death Protein-1 Ligand

PEI-SA

Poly(ethylenimine)-Succinic Acid

PI3K

Phosphatidylinositol 3-kinase

PIK3CA

Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Alpha

PIP2

Phosphatidylinositol-diphosphate

PIP3

Phosphatidylinositol-triphosphate

PLGA

Poly (Lactic-co-glycolic Acid)

PNIPAM-co-ALA

Poly(N-isopropylacrylamide-co-allylamine)

POT1

Protection of Telomeres 1

PRC2

Polycomb-repressive Complex 2

PTEN

Phosphatase and Tensin Homolog

PtNP

Platinum Nanoparticle

PVP

Poly(vinylpolypyrrolidone)

RNS

Reactive Nitrogen Species

ROS

Reactive Oxygen Species

RTK

Receptor Tyrosine Kinase

RT-qPCR

Reverse Transcription-quantitative Polymerase Chain Reaction

SCC

Squamous Cell Carcinoma

siRNA

Small Interfering Ribonucleic Acid

SLN

Solid Lipid Nanoparticle

SPBANP

Silver Prussian Blue Analog Nanoparticle

SSM

Superficial Spreading Melanoma

STAT3

Signal Transducer and Activator of Transcription 3

SWCNT

Single-wall Carbon Nanotube

TAM

Tumor-associated Macrophage

TCPP

Tetra-4-carboxy-phenyl Porphyrin

TERT

Telomerase Reverse Transcriptase

TME

Tumor Microenvironment

TNF-α

Tumor Necrosis Factor Alpha

Treg

Regulatory T Lymphocyte

VEGF

Vascular Endothelial Growth Factor

WHO

World Health Organization

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