NK has given talks, attended conferences and participated in trials sponsored by Amgen, Astra Zeneca, Boehringer Ingelheim, Elpen, Mylan, Novo Nordisk, Sanofi and Servier. DPM has given talks, acted as a consultant or attended conferences sponsored by Amgen and Novo Nordisk. MR has given lectures, received honoraria and research support, and participated in conferences, advisory boards and clinical trials sponsored by many pharmaceutical companies, including Amgen, Astra Zeneca, Boehringer