Reale M, Patruno A, De Lutiis MA, Pesce M, Felaco M, Di Giannantonio M, Di Nicola M, Grilli A (2011) Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controls. BMC Neurosci 12:13. https://doi.org/10.1186/1471-2202-12-13

Article  CAS  Google Scholar 

Ezeoke A, Mellor A, Buckley P, Miller BJ (2013) A systematic quantitative review of blood autoantibody elevations in schizophrenia. Schizophr Res 150:245–251

Article  Google Scholar 

Gibney SM, Drexhage HA (2013) Evidence for a dysregulated immune system in the etiology of psychiatric disorders. J Neuroimmune Pharmacol 8:900–920

Article  Google Scholar 

Sommer IE, van Westrhenen R, Begemann MJ, de Witte LD, Leucht S, Kahn RS (2014) Efficacy of anti-inflammatory agents to improve symptoms in patients with schizophrenia: an update. Schizophr Bull 40:181–191

Article  Google Scholar 

Girgis RR, Kumar SS, Brown AS (2014) The cytokine model of schizophrenia: emerging therapeutic strategies. Biol Psychiatry 75(4):292–299

Article  CAS  Google Scholar 

Wang AK, Miller BJ (2018) Meta-analysis of cerebrospinal fluid cytokine and tryptophan catabolite alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder, and depression. Schizophr Bull 44(1):75–83

Article  Google Scholar 

Harris LW, Pietsch S, Cheng TM, Schwarz E, Guest PC, Bahn S (2012) Comparison of peripheral and central schizophrenia biomarker profiles. PLoS ONE 7(10):e46368. https://doi.org/10.1371/journal.pone.0046368

Article  CAS  Google Scholar 

Guest PC, Guest FL, Martins-de Souza D (2016) Making sense of blood-based proteomics and metabolomics in psychiatric research. Int J Neuropsychopharmacol 19(6):pyv138. https://doi.org/10.1093/ijnp/pyv138

Article  Google Scholar 

Misra BB, Langefeld CD, Olivier M, Cox LA (2018) Integrated omics: tools, advances, and future approaches. J Mol Endocrinol. https://doi.org/10.1530/JME-18-0055. (JME-18-0055)

Article  Google Scholar 

Subramanian I, Verma S, Kumar S, Jere A, Anamika K (2020) Multi-omics data integration, interpretation, and its application. Bioinform Biol Insights 14:1177932219899051. https://doi.org/10.1177/1177932219899051

Article  Google Scholar 

Gallego JA, Blanco EA, Husain-Krautter S, Madeline Fagen E, Moreno-Merino P, Del Ojo-Jiménez JA, Ahmed A, Rothstein TL, Lencz T, Malhotra AK (2018) Cytokines in cerebrospinal fluid of patients with schizophrenia spectrum disorders: new data and an updated meta-analysis. Schizophr Res 202:64–71

Article  Google Scholar 

Fu Q, Zhu J, Van Eyk JE (2010) Comparison of multiplex immunoassay platforms. Clin Chem 56(2):314–318

Article  CAS  Google Scholar 

Stephen L, Schwarz E, Guest PC (2017) Multiplex immunoassay profiling of serum in psychiatric disorders. Adv Exp Med Biol 974:149–156

Article  CAS  Google Scholar 

Liu MY, Xydakis AM, Hoogeveen RC, Jones PH, Smith EO, Nelson KW, Ballantyne CM (2005) Multiplexed analysis of biomarkers related to obesity and the metabolic syndrome in human plasma, using the Luminex-100 system. Clin Chem 51(7):1102–1109

Article  CAS  Google Scholar 

Codorean E, Nichita C, Albulescu L, Răducan E, Popescu ID, Lonită AC, Albulescu R (2010) Correlation of XMAP and ELISA cytokine profiles; development and validation for immunotoxicological studies in vitro. Roum Arch Microbiol Immunol 69(1):13–19

CAS  Google Scholar 

Clinical and Laboratory Standards Institute. Protocols for Determination of Limits of Detection and Limits of Quantitation, Approved Guideline. CLSI document EP17. Wayne, PA USA: CLSI; 2004. https://webstore.ansi.org/preview-pages/CLSI/preview_EP17-A.pdf. Accessed 7 Sept 2022.

Maxeiner HG, Marion Schneider E, Kurfiss ST, Brettschneider J, Tumani H, Bechter K (2014) Cerebrospinal fluid and serum cytokine profiling to detect immune control of infectious and inflammatory neurological and psychiatric diseases. Cytokine 69(1):62–67

Article  CAS  Google Scholar 

Hestad KA, Engedal K, Whist JE, Aukrust P, Farup PG, Mollnes TE, Ueland T (2016) Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis. Neuropsychiatr Dis Treat 12:817–822

Article  CAS  Google Scholar 

Kuzior H, Fiebich BL, Yousif NM, Saliba SW, Ziegler C, Nickel K, Maier SJ, Süß P, Runge K, Matysik M, Dersch R, Berger B, Robinson T, Venhoff N, Kessler F, Blank T, Domschke K, Tebartz van Elst L, Endres D (2020) Increased IL-8 concentrations in the cerebrospinal fluid of patients with unipolar depression. Compr Psychiatry 102:152196. https://doi.org/10.1016/j.comppsych.2020.152196

Article  Google Scholar 

Hidese S, Hattori K, Sasayama D, Tsumagari T, Miyakawa T, Matsumura R, Yokota Y, Ishida I, Matsuo J, Yoshida S, Ota M, Kunugi H (2021) Cerebrospinal fluid inflammatory cytokine levels in patients with major psychiatric disorders: a multiplex immunoassay study. Front Pharmacol 11:594394. https://doi.org/10.3389/fphar.2020.594394

Article  CAS  Google Scholar 

Runge K, Fiebich BL, Kuzior H, Saliba SW, Yousif NM, Meixensberger S, Nickel K, Denzel D, Schiele MA, Maier SJ, Berger B, Dersch R, Domschke K, Tebartz van Elst L, Endres D (2021) An observational study investigating cytokine levels in the cerebrospinal fluid of patients with schizophrenia spectrum disorders. Schizophr Res 231:205–213

Article  CAS  Google Scholar 

Armbruster DA, Pry T (2008) Limit of blank, limit of detection and limit of quantitation. Clin Biochem Rev 29(Suppl 1):S49-52

Google Scholar 

World Health Organization (2015) The international statistical classification of diseases and related health problems, ICD-10: 10th Revision (ICD-10). World Health Organization; Geneva, Switzerland. ISBN-13: 978–9241549165.

Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13(2):261–276

Article  CAS  Google Scholar 

Atkins M, Burgess A, Bottomley C, Riccio M (1997) Chlorpromazine equivalents: a consensus of opinion for both clinical and research applications. Psychiatr Bull 21(4):224–226

Article  Google Scholar 

Obermeier M, Schennach-Wolff R, Meyer S, Möller HJ, Riedel M, Krause D, Seemüller F (2011) Is the PANSS used correctly? A systematic review. BMC Psychiatry 11:113. https://doi.org/10.1186/1471-244X-11-113

Article  Google Scholar 

Cohen J (1988) Statistical power analysis for the behavioral sciences. Routledge; 2nd edition; Abingdon-on-Thames, Oxfordshire, England, UK. ISBN-13: 978-0805802832

Schwarz E, van Beveren NJ, Ramsey J, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Guest PC, Bahn S (2014) Identification of subgroups of schizophrenia patients with changes in either immune or growth factor and hormonal pathways. Schizophr Bull 40(4):787–795

Article  CAS  Google Scholar 

Steiner J, Bernstein HG, Schiltz K, Müller UJ, Westphal S, Drexhage HA, Bogerts B (2014) Immune system and glucose metabolism interaction in schizophrenia: a chicken-egg dilemma. Prog Neuropsychopharmacol Biol Psychiatry 48:287–294

Article  CAS  Google Scholar 

Klaus F, Mitchell K, Liou SC, Eyler LT, Nguyen TT (2021) Chemokine MCP1 is associated with cognitive flexibility in schizophrenia: a preliminary analysis. J Psychiatr Res 138:139–145

Article  Google Scholar 

Dunleavy C, Elsworthy RJ, Upthegrove R, Wood SJ, Aldred S (2022) Inflammation in first-episode psychosis: the contribution of inflammatory biomarkers to the emergence of negative symptoms, a systematic review and meta-analysis. Acta Psychiatr Scand 146(1):6–20

Article  Google Scholar 

Ermakov EA, Melamud MM, Buneva VN, Ivanova SA (2022) Immune system abnormalities in schizophrenia: an integrative view and translational perspectives. Front Psychiatry 13:880568. https://doi.org/10.3389/fpsyt.2022.880568

Article  Google Scholar 

Drexhage RC, Padmos RC, de Wit H, Versnel MA, Hooijkaas H, van der Lely AJ, van Beveren N, deRijk RH, Cohen D (2008) Patients with schizophrenia show raised serum levels of the pro-inflammatory chemokine CCL2: association with the metabolic syndrome in patients? Schizophr Res 102(1–3):352–355

Article  Google Scholar 

Harris LW, Guest PC, Wayland MT, Umrania Y, Krishnamurthy D, Rahmoune H, Bahn S (2013) Schizophrenia: metabolic aspects of aetiology, diagnosis and future treatment strategies. Psychoneuroendocrinology 38(6):752–766

Article  CAS  Google Scholar 

Leick L, Lindegaard B, Stensvold D, Plomgaard P, Saltin B, Pilegaard H (2007) Adipose tissue interleukin-18 mRNA and plasma interleukin-18: effect of obesity and exercise. Obesity (Silver Spring) 15(2):356–363

Article  CAS  Google Scholar 

Bruun JM, Stallknecht B, Helge JW, Richelsen B (2007) Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss. Eur J Endocrinol 157(4):465–471

Article  CAS  Google Scholar 

Jung C, Gerdes N, Fritzenwanger M, Figulla HR (2010) Circulating levels of interleukin-1 family cytokines in overweight adolescents. Mediat Inflamm 2010:958403. https://doi.org/10.1155/2010/958403

Article  CAS  Google Scholar 

Ahmad R, Thomas R, Kochumon S, Sindhu S (2017) Increased adipose tissue expression of IL-18R and its ligand IL-18 associates with inflammation and insulin resistance in obesity. Immun Inflamm Dis 5(3):318–335

Article  CAS  Google Scholar 

Bankul A, Mitra P, Suri S, Saxena I, Shukla R, Shukla K, Sharma P (2020) Increased serum IL-18 levels and IL-18R expression in newly diagnosed type 2 diabetes mellitus. Minerva Endocrinol. https://doi.org/10.23736/S0391-1977.20.03271-X

Article  Google Scholar 

Nedeva I, Gateva A, Assyov Y, Karamfilova V, Hristova J, Yamanishi K, Kamenov Z, Okamura H (2022) IL-18 serum levels in patients with obesity, prediabetes and newly diagnosed type 2 diabetes. Iran J Immunol 19(2):199–206

Google Scholar 

Potůčková L, Franko F, Bambousková M, Dráber P (2011) Rapid and sensitive detection of cytokines using functionalized gold nanoparticle-based immuno-PCR, comparison with immuno-PCR and ELISA. J Immunol Methods 371(1–2):38–47

Article  Google Scholar 

Dahiya B, Mehta PK (2019) Detection of potential biomarkers associated with outrageous diseases and environmental pollutants by nanoparticle-based immuno-PCR assays. Anal Biochem 587:113444. https://doi.org/10.1016/j.ab.2019.113444

Article  CAS  Google Scholar 

Lee S, Cho NP, Kim JD, Jung H, Kang SH (2009) An ultra-sensitive nanoarray chip based on single-molecule sandwich immunoassay and TIRFM for protein detection in biologic fluids. Analyst 134(5):933–938

Article  CAS  Google Scholar 

Rissin DM, Kan CW, Song L, Rivnak AJ, Fishburn MW, Shao Q, Piech T, Ferrell EP, Meyer RE, Campbell TG, Fournier DR, Duffy DC (2013) Multiplexed single molecule immunoassays. Lab Chip 13(15):2902–2911

Article  CAS  Google Scholar