Regulation of Cisplatin Resistance in Bladder Cancer by Epigenetic Mechanisms

NMIBC

Nonmuscle invasive bladder cancer

MIBC

Muscle invasive bladder cancer

TLX3

T-cell leukemia homeobox 3

GULP1

Engulfment adaptor phosphotyrosine-binding domain containing 1

KEAP1

Kelch-like ECH-associated protein-1

NRF2

Nuclear factor erythroid 2-related factor 2

UCB

Urothelial cancer of the bladder

ASS1

Argininosuccinate synthase 1

SAT1

Spermidine/spermine N1-acetyltransferase

ADI-PEG 20

Pegylated arginine deiminase

DNMTs

DNA methyltransferases

SOCS3

Suppressor of cytokine signalling-3

RASSF1A

Ras association domain family 1 isoform A

CTGF

Connective tissue growth factor

CYR61

Cysteine-rich angiogenic inducer 61

HAX-1

Hematopoietic cell-specific protein 1-associated protein X-1

EHHADH

Enoyl-CoAhydratase/3-hydroxyacyl CoA dehydrogenase

IGFBP3

Insulin growth factor binding protein 3

ICAM1

Intercellular adhesion molecule-1

TNFSF10

Tumor necrosis factor-related apoptosis-inducing ligand

HIF-1α

Hypoxia-inducible factor-1α

hTERT

Human telomerase reverse transcriptase

PDCD4

Programmed cell death 4

mTOR

Mammalian target of rapamycin

VEGFC

Vascular endothelial growth factor C

ERK5

Extracellular signal-regulated kinase 5

PPP2R2A

Protein phosphatase 2A subunit B

PI3K

Phosphatidylinositol-3-kinase

STAT

Signal transducer of activators of transcription

CDK6

Cyclin-dependent kinase 6

GOLPH3

Golgi phosphoprotein 3

BMI1

B-cell specific Moloney murine leukemia virus integration region 1

ABCB1

ATP binding cassette subfamily B member 1

SLC7A11

Solute carrier family 7 member 11

EZH2

Enhancer of zeste homolog 2

CEBPD

CCAAT/enhancer binding protein delta

PARP

Poly (ADP-ribose) polymerase

TCC

Transitional cell carcinoma

ROCK

Rho-associated protein kinase

LncRNA

Long non-coding RNA

MEG3

Maternally expressed gene 3

MMP2

Matrix metalloproteinase-2

MMP9

Matrix metalloproteinase-9

PVT1

Plasmacytoma variant translocation 1

LMAN1

Lectin mannose-binding protein 1

HIF1A-AS2

hypoxia inducible factor 1α‐antisense RNA 2

HMGA1

High‐mobility group A1

NEAT1

Nuclear paraspeckle assembly transcript 1

OCT4

Octamer-binding transcription factor 4

UCA1

Urothelial cancer associated 1

CUDR

Cancer upregulated drug resistant

CREB

cAMP-response-element-binding protein

ceRNAs

Competing endogenous RNAs

DLEU1

Deleted in lymphocytic leukemia 1

HS3ST3B1

Heparan Sulfate-Glucosamine 3-Sulfotransferase 3B1

TUG1

Taurine-upregulated gene 1

MALAT1

Metastasis-associated lung adenocarcinoma transcript 1

EMT

Epithelial-mesenchymal transition

APAF1

Apoptotic protease-activating factor 1

ARE

Androgen response element

KRAS

Kirsten rat sarcoma viral oncogene homologue

CDC25B

Cell division cycle 25B

MDSCs

Marrow-derived suppressor cells

METTL3

N6-adenosine-methyltransferase 70 kDa subunit

WTAP

Wilms' tumor 1-conjugating protein

MDSC

Myeloid-derived suppressor cell

G-CSG

Granulocyte colony-stimulating factors

TNFAIP3

TNF alpha-induced protein 3

ALKBH5

AlkB homolog 5 RNA demethylase

G-CSF

Granulocyte colony-stimulating factor

PTMs

Posttranslational modifications

SUMO

Small ubiquitin-related modifier

ER-β

Estrogen receptor-β

FGFR3

Fibroblast growth factor receptor 3

GRIM19

Gene associated with retinoid-interferon-induced mortality-19

CIP2A

Cancerous inhibitor of protein phosphatase 2A

HATs

Histone acetyltransferases

HDACs

Histone deacetylases

HMGN5

High mobility group nucleosome binding domain 5

KDM7A

Lysine demethylase 7A

SPHK1

Sphingosine kinase 1

USP14

Ubiquitin specific peptidase 14

USP21

Ubiquitin specific peptidase 21

WDR5

WD repeat structural domain 5

MAPK

Mitogen-activated protein kinases

JNK

c-Jun N-terminal kinase

CDK2

Cyclin-dependent kinase 2

MDR1

Multidrug resistance protein 1

ACSS2

Acetyl-CoA synthetase 2

OGT

O-linked-β-N-acetylglucosamine transferase

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