Letter to the editor about published meta-analysis of TMAO and stroke

Zhang H, Yao G. Significant correlation between the gut microbiota-derived metabolite trimethylamine-N-oxide and the risk of stroke: evidence based on 23 observational studies. Eur J Clin Nutr. 2022. https://doi.org/10.1038/s41430-022-01104-7.

Tang WH, Wang Z, Li XS, Fan Y, Li DS, Wu Y, et al. Increased trimethylamine N-oxide portends high mortality risk independent of glycemic control in patients with type 2 diabetes mellitus. Clin Chem. 2017;63:297–306.

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Guasch-Férre M, Hu FB, Ruiz-Canela M, Bullo M, Toledo E, Wang DD, et al. Plasma metabolites from choline pathway and risk of cardiovascular disease in the PREDIMED (Prevention With Mediterranean Diet) Study. J Am Heart Assoc. 2017;6:e006524.

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