Antimicrobial susceptibility of anaerobic clinical isolates: A two-year surveillance

Anaerobic bacteria form a part of the typical human microbiota and are involved in a broad range of human infections [1]. They are considered invasive opportunistic pathogens following the disruption of a mucosal surface (by surgery or traumatic injury) and the contamination of adjacent, generally sterile spaces and/or tissues [2].

Anaerobic bacterial infections are common and can result in diseases associated with severe morbidity, particularly in patients with comorbidities, such as diabetes, obesity or immunosuppression [[1], [2], [3]]. They can affect a variety of body areas such as the head and neck, abdominal cavity, bowel and pelvis. Moreover, anaerobes can be responsible for skin and soft tissue infections (such as diabetic foot and bedsore infections). In certain cases, anaerobic bacteria can lead to bacteraemia, intra-abdominal sepsis, puerperal sepsis and, rarely, endocarditis and pericarditis [2].

In recent years, an increase in global antimicrobial resistance has been observed, which is associated with a risk of more severe clinical outcomes and death [1,4]. However, although several studies concerning the resistance of anaerobic bacteria to antimicrobial agents have been conducted globally [[5], [6], [7], [8], [9]], the available data are not exhaustive because of technical difficulties regarding the isolation of the bacteria and susceptibility testing, which is expensive, time-consuming and requires expertise. Moreover, the lack of common applied guidelines for susceptibility testing and interpretation criteria has resulted in difficulty in assessing the resistance of anaerobic bacteria to eradication therapy [10].

This study aimed to evaluate (through a monocentric study and for the first time in Italy) the susceptibility of anaerobic bacteria to antimicrobial drugs and the extent of the resistance according to distinct genera of these bacteria isolated from various types of clinical samples.

留言 (0)

沒有登入
gif