In vitro and in vivo synergistic effects of hydroxychloroquine and itraconazole on Cryptococcus neoformans

Al-Bari MA (2015) Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases. J Antimicrob Chemother 70:1608–1621. https://doi.org/10.1093/jac/dkv018

Article  CAS  Google Scholar 

Al-Fattani MA, Douglas LJ (2004) Penetration of Candida biofilms by antifungal agents. Antimicrob Agents Chemother 48:3291–3297. https://doi.org/10.1128/AAC.48.9.3291-3297.2004

Article  CAS  Google Scholar 

Alanio A (2020) Dormancy in Cryptococcus neoformans: 60 years of accumulating evidence. J Clin Invest 130:3353–3360. https://doi.org/10.1172/JCI136223

Article  CAS  Google Scholar 

Ashburn TT, Thor KB (2004) Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov 3:673–683. https://doi.org/10.1038/nrd1468

Article  CAS  Google Scholar 

Boelaert JR, Appelberg R, Gomes MS, Blasi E, Mazzolla R, Grosset J et al (2001) Experimental results on chloroquine and aids-related opportunistic infections. J Acquir Immune Defic Syndr 26:300–301. https://doi.org/10.1097/00042560-200103010-00017

Article  CAS  Google Scholar 

Brown GD, Denning DW, Gow NA, Levitz SM, Netea MG, White TC (2012) Hidden killers: human fungal infections. Sci Transl Med 4:165rv13. https://doi.org/10.1126/scitranslmed.3004404

Costerton JW, Stewart PS, Greenberg EP (1999) Bacterial biofilms: a common cause of persistent infections. Science 284:1318–1322. https://doi.org/10.1126/science.284.5418.1318

Article  CAS  Google Scholar 

Geddes-McAlister J, Shapiro RS (2019) New pathogens, new tricks: emerging, drug-resistant fungal pathogens and future prospects for antifungal therapeutics. Ann N Y Acad Sci 1435:57–78. https://doi.org/10.1111/nyas.13739

Article  Google Scholar 

Ghaffar M, Orr C, Webb G (2019) Antiphagocytic protein 1 increases the susceptibility of Cryptococcus neoformans to amphotericin B and fluconazole. PLoS One 14:e0225701. https://doi.org/10.1371/journal.pone.0225701

Henriet SS, Jans J, Simonetti E, Kwon-Chung KJ, Rijs AJ, Hermans PW et al (2013) Chloroquine modulates the fungal immune response in phagocytic cells from patients with chronic granulomatous disease. J Infect Dis 207:1932–1939. https://doi.org/10.1093/infdis/jit103

Article  CAS  Google Scholar 

Huang Z, Srinivasan S, Zhang J, Chen K, Li Y, Li W et al (2012) Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy. PLoS Genet 8:e1003083. https://doi.org/10.1371/journal.pgen.1003083

Jarvis JN, Lawrence DS, Meya DB, Kagimu E, Kasibante J, Mpoza E et al (2022) Single-dose liposomal amphotericin B treatment for cryptococcal meningitis. N Engl J Med 386:1109–1120. https://doi.org/10.1056/NEJMoa2111904

Article  CAS  Google Scholar 

Jiang Y, Dukik K, Muñoz JF, Sigler L, Schwartz IS, Govender NP et al (2018) Phylogeny, ecology and taxonomy of systemic pathogens and their relatives in ajellomycetaceae (onygenales): blastomyces, emergomyces, emmonsia, emmonsiellopsis. Fungal Diversity 90:245–291. https://doi.org/10.1007/s13225-018-0403-y

Article  Google Scholar 

Jorjao AL, Oliveira LD, Scorzoni L, Figueiredo-Godoi LMA, Cristina APM, Jorge AOC et al (2018) From moths to caterpillars: ideal conditions for Galleria Mellonella rearing for in vivo microbiological Studies. Virulence 9:383–9. https://doi.org/10.1080/21505594.2017.1397871

Kaufmann AM, Krise JP (2007) Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications. J Pharm Sci 96:729–746. https://doi.org/10.1002/jps.20792

Article  CAS  Google Scholar 

Keshavarzi F (2016) Fungistatic effect of hydroxychloroquine, lessons from a case. Med Mycol Case Rep 13:17–18. https://doi.org/10.1016/j.mmcr.2016.09.003

Article  Google Scholar 

Kligman AM, Weidman FD (1949) Experimental studies on treatment of human torulosis. Arch Derm Syphilol 60:726–741. https://doi.org/10.1001/archderm.1949.01530050088008

Article  CAS  Google Scholar 

Krezdorn J, Adams S, Coote PJ (2014) A Galleria Mellonella infection model reveals double and triple antibiotic combination therapies with enhanced efficacy versus a multidrug-resistant strain of Pseudomonas aeruginosa. J Med Microbiol 63:945–955. https://doi.org/10.1099/jmm.0.074245-0

Article  Google Scholar 

Krysan DJ (2017) The unmet clinical need of novel antifungal drugs. Virulence 8:135–137. https://doi.org/10.1080/21505594.2016.1276692

Article  Google Scholar 

Kumari P, Mishra R, Arora N, Chatrath A, Gangwar R, Roy P et al (2017) Antifungal and anti-biofilm activity of essential oil active components against Cryptococcus neoformans and Cryptococcus laurentii. Front Microbiol 8:2161. https://doi.org/10.3389/fmicb.2017.02161

Article  Google Scholar 

Levitz SM, Harrison TS, Tabuni A, Liu X (1997) Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation. J Clin Invest 100:1640–1646. https://doi.org/10.1172/jci119688

Article  CAS  Google Scholar 

Li L, Sun J, Xia S, Tian X, Cheserek MJ, Le G (2016) Mechanism of antifungal activity of antimicrobial peptide App, a cell-penetrating peptide derivative, against Candida albicans: intracellular DNA binding and cell cycle arrest. Appl Microbiol Biotechnol 100:3245–3253. https://doi.org/10.1007/s00253-015-7265-y

Article  CAS  Google Scholar 

Lu M, Yang X, Yu C, Gong Y, Yuan L, Hao L et al (2018) Linezolid in combination with azoles induced synergistic effects against Candida albicans and protected galleria mellonella against experimental candidiasis. Front Microbiol 9:3142. https://doi.org/10.3389/fmicb.2018.03142

Article  Google Scholar 

Luo W, Che D, Lu H, Jiang Y (2020) New perspectives from misdiagnosis: a case of primary cutaneous cryptococcosis treated with hydroxychloroquine sulfate successfully. Mycopathologia 185:595–596. https://doi.org/10.1007/s11046-020-00454-9

Article  CAS  Google Scholar 

Martinez LR, Casadevall A (2006) Cryptococcus neoformans cells in biofilms are less susceptible than planktonic cells to antimicrobial molecules produced by the innate immune system. Infect Immun 74:6118–6123. https://doi.org/10.1128/IAI.00995-06

Article  CAS  Google Scholar 

Martinez LR, Fries BC (2010) Fungal biofilms: relevance in the setting of human disease. Curr Fungal Infect Rep 4:266–275. https://doi.org/10.1007/s12281-010-0035-5

Article  Google Scholar 

Michaud M, Gaches FHydroxychloroquine in systemic lupus erythematosus: comment on the article by muangchan, et al (2016) Arthritis Care Res (hoboken) 68:1052–1053. https://doi.org/10.1002/acr.22780

Article  Google Scholar 

Narayanan S, Banerjee C, Holt PA (2011) Cryptococcal immune reconstitution syndrome during steroid withdrawal treated with hydroxychloroquine. Int J Infect Dis 15:e70–e73. https://doi.org/10.1016/j.ijid.2010.09.006

Article  Google Scholar 

Newman SL, Gootee L, Brunner G, Deepe GS Jr (1994) Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis. J Clin Invest 93:1422–1429. https://doi.org/10.1172/jci117119

Article  CAS  Google Scholar 

Perfect JR (2016) Is there an emerging need for new antifungals? Expert Opin Emerg Drugs 21:129–131. https://doi.org/10.1517/14728214.2016.1155554

Article  Google Scholar 

Peyclit L, Yousfi H, Rolain JM, Bittar F (2021) Drug repurposing in medical mycology: identification of compounds as potential antifungals to overcome the emergence of multidrug-resistant fungi. Pharmaceuticals (Basel) 14. https://doi.org/10.3390/ph14050488

Pierce CG, Uppuluri P, Tristan AR, Wormley FL, Mowat E, Ramage G et al (2008) A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing. Nat Protoc 3:1494–1500. https://doi.org/10.1038/nprot.2008.141

Article  CAS  Google Scholar 

Rossato L, Camargo Dos Santos M, Vitale RG, de Hoog S, Ishida K (2021) Alternative treatment of fungal infections: synergy with non-antifungal agents. Mycoses 64:232–244. https://doi.org/10.1111/myc.13203

Article  Google Scholar 

Sangalli-Leite F, Scorzoni L, Alves de Paula ESAC, da Silva JF, de Oliveira HC, de Lacorte SJ et al (2016) Synergistic effect of pedalitin and amphotericin B against Cryptococcus neoformans by in vitro and in vivo evaluation. Int J Antimicrob Agents 48:504–511. https://doi.org/10.1016/j.ijantimicag.2016.07.025

Article  CAS  Google Scholar 

Schrezenmeier E, Dorner T (2020) Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nat Rev Rheumatol 16:155–166. https://doi.org/10.1038/s41584-020-0372-x

Article  CAS  Google Scholar 

Shinde RB, Rajput SB, Raut JS, Karuppayil SM (2013) An in vitro repositioning study reveals antifungal potential of chloroquine to inhibit growth and morphogenesis in Candida albicans. J Gen Appl Microbiol 59:167–170. https://doi.org/10.2323/jgam.59.167

Article  CAS  Google Scholar 

Su S, Yan H, Min L, Wang H, Chen X, Shi J et al (2022) The antifungal activity of caspofungin in combination with antifungals or non-antifungals against Candida species in vitro and in clinical therapy. Expert Rev Anti Infect Ther 20:161–178. https://doi.org/10.1080/14787210.2021.1941868

Article  CAS  Google Scholar 

Vesterinen HM, Connick P, Irvine CM, Sena ES, Egan KJ, Carmichael GG et al (2015) Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis. PLoS One 10:e0117705. https://doi.org/10.1371/journal.pone.0117705

Vilcinskas A (2011) Insects emerge as valuable model hosts to explore virulence. Virulence 2:376–8. Epub 2011/10/22. https://doi.org/10.4161/viru.2.5.18289

Weber SM, Levitz SM, Harrison TS (2000) Chloroquine and the fungal phagosome. Curr Opin Microbiol 3:349–53. https://doi.org/10.1016/s1369-5274(00)00102-8

Yang L, Tian Z, Zhou L, Zhu L, Sun C, Huang M et al (2022) In vitro antifungal activity of a novel antimicrobial peptide Amp-17 against planktonic cells and biofilms of Cryptococcus neoformans. Infect Drug Resist 15:233–248. https://doi.org/10.2147/IDR.S344246

Article  CAS  Google Scholar 

Zaragoza O (2019) Basic principles of the virulence of Cryptococcus. Virulence 10:490–501. https://doi.org/10.1080/21505594.2019.1614383

Article  CAS  Google Scholar 

Zuo R, Garrison AT, Basak A, Zhang P, Huigens RW 3rd, Ding Y (2016) In vitro antifungal and antibiofilm activities of halogenated quinoline analogues against Candida albicans and Cryptococcus neoformans. Int J Antimicrob Agents 48:208–211. https://doi.org/10.1016/j.ijantimicag.2016.04.019

Article  CAS  Google Scholar 

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