aObstetrics and Gynecology, The First Affiliated Hospital of Soochow University

bDepartment of Pathology and Pathophysiology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou

cDepartment of Reproductive Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu

dDepartment of Emergency Surgery

eInstitute for Fetology, The First Affiliated Hospital of Soochow University

fDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Orthopaedic Institute of Soochow University, Soochow University, Suzhou, China

Correspondence to Pengjie Zhang, Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. E-mail: [email protected]

Abbreviations: BP, blood pressure; CircRNA, circular RNA; CSPD, chloro-5-substituted adamantly-1,2-dioxetane phosphate; CTRL, healthy pregnant controls; DAPI, 4’,6-diamidino-2-phenylindole; DIG, digoxin; ECL, efficient chemiluminescence; EOPE, early-onset preeclampsia; EVT, extravillous trophoblast; FISH, fluorescence in situ hybridization; GD, gestational day; L-NAME, NG-nitro-l-arginine methyl ester; NO, nitric oxide; PE, preeclampsia; PVDF, polyvinylidene fluoride; ROC, receiving operating characteristic; VEGF-A, vascular endothelial growth factor-A

Received 17 August, 2022

Revised 27 October, 2022

Accepted 28 November, 2022

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