Inhibition of Hexokinase 2 with 3-BrPA Promotes MDSCs Differentiation and Immunosuppressive function

Keywords

hexokinase 2

3-bromopyruvic acid

myeloid-derived suppressor cells

allogeneic heart transplant

STAT3

cellular therapy

Abbreviations3-BrPA

3-bromopyruvic acid

CFSE

5,6-carboxyfluorescein diacetate succinimidyl ester

CXCR2

CXC chemokine receptor 2

ECAR

extracellular acidification rate

GM-CSF

granulocyte macrophage colony stimulating factor

iNOS

inducible nitric oxide synthase

MDSCs

myeloid-derived suppressor cells

PD-1

programmed cell death receptors 1

PD-L1

programmed cell death-ligand 1

STAT3

Signal transducer and activator of transcription 3

Data availability

Data will be made available on request.

© 2023 The Author(s). Published by Elsevier Inc.

留言 (0)

沒有登入
gif