Using the Comprehensive Complication Index to Rethink the ISGLS Criteria for Post-hepatectomy Liver Failure in an International Cohort of Major Hepatectomies

*School of Medicine, University of California San Francisco, San Francisco, CA

†Department of Human Structure and Repair, Ghent University, Ghent, Belgium

‡Department of Surgery, Poliambulanza Foundation Hospital, Brescia, italy

§Department of Surgery, University Hospital Southampton NHS Trust, Southampton, UK

¶Department of Surgery, University of California San Francisco, San Francisco, CA

||Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan

**Division of Plastic Surgery, Department of Surgery, University of California San Francisco, San Francisco, CA

††International Post-Hepatectomy Liver Failure Study Group: Yuta Abe (Department of Surgery, Keio University School of Medicine, Tokyo, Japan); Thomas Armstrong (Department of Surgery, University Hospital Southampton NHS Trust, Southampton, UK); Alessandro Ferrero (Department of General and Oncological Surgery, Umberto I Mauriziano Hospital, Largo Turati, Turin, Italy); Carlos Corvera (Department ofSurgery, Division of Surgical Oncology, University ofCalifornia San Francisco, San Francisco, CA); Koki Hayashi (Department of Surgery, Keio University School of Medicine, Tokyo, Japan); Taisuke Imamura (Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Sunto-Nagaizumi, Shizuoka, Japan); Minoru Kitago (Department ofSurgery, Keio University School of Medicine, Tokyo, Japan); Shoji Kubo (Department ofHepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School ofMedicine, Osaka, Japan); Masatsugu Ishii (Department ofPediatric Surgery and Transplantation, Kumamoto University Graduate School ofMedical Sciences, Kumamoto, Japan); Federico Mocchegiani (Hepatobiliary and Abdominal Transplantation Surgery, Department ofExperimental and Clinical Medicine, Riuniti Hospital, Polytechnic University ofMarche, Ancona, Italy); Zenichi Morise (Department ofSurgery, Okazaki Medical Center, Fujita Health University School ofMedicine, Okazaki, Japan); Kosuke Ogawa (Department ofHepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan); Yukiyasu Okamura (Division ofHepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Sunto-Nagaizumi, Shizuoka, Japan); Shimpei Otsuka (Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Sunto-Nagaizumi, Shizuoka, Japan); John Primrose (Department ofSurgery, University Hospital Southampton NHS Trust, Southampton, UK); Edoardo Rosso (Department ofSurgery, Poliambulanza Foundation Hospital, Brescia, Italy; Department of Surgery, Elsan Pôle Santé Sud, Le Mans, France); Fernando Rotellar (HPB and Liver Transplant Unit. Department of General and Digestive Surgery, Clínica Universidad de Navarra, Pamplona, Spain); Nadia Russolillo (Department of General and Oncological Surgery, Umberto I Mauriziano Hospital, Largo Turati, Turin, Italy); Shareef M Syed (Department of Surgery, Division of Abdominal Transplantation, University ofCalifornia San Francisco, San Francisco, CA); Minoru Tanabe (Department ofHepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan); Shogo Tanaka (Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School ofMedicine, Osaka, Japan); Fumihiro Terasaki (Division ofHepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Sunto-Nagaizumi, Shizuoka, Japan); Marco Vivarelli (Hepatobiliary and Abdominal Transplantation Surgery, Department of Experimental and Clinical Medicine, Riuniti Hospital, Polytechnic University ofMarche, Ancona, Italy); Giuseppe Zimmitti (Department of Surgery, Poliambulanza Foundation Hospital, Brescia, Italy)

[email protected].

P.C.C. was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, UCSF-CTSI Grant Number TL1 TR001871. These contents are solely the responsibility of the authors and do not necessarily represent the official views of the NiH.

The authors report no conflicts of interest.

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