We thank the participants of the TARGET and SELECT-BEYOND trials.

Funding

This study was funded by Sanofi. Publication of this article and the journal’s Rapid Service Fee were also funded by Sanofi.

Medical Writing/Editorial Assistance

Medical writing assistance, funded by Sanofi, was provided by Vojislav Pejović, PhD, Richard J. Hogan, PhD, and Rania Kairouz-Wahbe, PhD, of Elevate Medical Affairs, a division of Envision Pharma Group.

Author Contributions

Thomas Huizinga, Ernest Choy, Amy Praestgaard, Hubert van Hoogstraten, Patrick R. LaFontaine, Patricia Guyot, Daniel Aletaha, Ulf Müller-Ladner, Jeffrey R. Curtis and Roy Fleischmann were all involved in the design of the study, collecting and interpreting the data, the drafting of the manuscript, and critical revisions. Statistical analysis was done by Amy Praestgaard. The final version of the manuscript was approved by all authors, who had full access to all of the data in the study and had final responsibility for the decision to submit the manuscript for publication.

Prior Presentation

These data were presented at the American College of Rheumatology Convergence, Virtual, November 5–9, 2020 (Abstract 0827).

Disclosures

Thomas Huizinga has received grants and/or consultant fees from Ablynx, Bristol Myers Squibb, Roche, and Sanofi. Ernest Choy has received grant/research support (Amgen, Bio-Cancer, Chugai Pharma, Pfizer, Roche, UCB); consulting fees (AbbVie, Amgen, Biogen, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Chugai Pharma, Eli Lilly, GlaxoSmithKline, Hospita, Ionis, Jazz Pharmaceuticals, Janssen, Merck Serono, Novartis, Novimmune, ObsEva, Pfizer, R-Pharm, Regeneron Pharmaceuticals, Inc, Roche, SynAct Pharma, Sanofi-Genzyme, UCB); and speaking fees (Amgen, Bristol Myers Squibb, Chugai Pharma, Eli Lilly, Novartis, Pfizer, Regeneron Pharmaceuticals, Inc, Roche, Sanofi-Genzyme, UCB). Amy Praestgaard, Hubert van Hoogstraten, Patrick R. LaFontaine, and Patricia Guyot are employees of Sanofi and may own company stock. Daniel Aletaha has received grant/research support, consulting fees, and/or speaker fees/honoraria from AbbVie, Amgen, Celgene, Lilly, Medac, Merck, Novartis, Pfizer, Roche, Sandoz, Sanofi Genzyme, and UCB. Ulf Müller-Ladner has acted as speaker/advisor for AbbVie and Sanofi. Yoshiya Tanaka has received speaking fees and/or honoraria from Daiichi-Sankyo, Eli Lilly, Novartis, YL Biologics, Bristol Myers Squibb, Eisai, Chugai, Abbvie, Astellas, Pfizer, Sanofi, Asahi-kasei, GSK, Mitsubishi-Tanabe, Gilead, Janssen and has received research grants from Mitsubishi-Tanabe, Chugai, Abbvie, Takeda, UCB, Daiichi-Sankyo, Eisai. Jeffrey R. Curtis has received consulting and research grants from AbbVie, Amgen, BMS, Gilead, GSK, Janssen, Lilly, Myriad, Pfizer, Roche, Samsung, Sandoz, Sanofi, UCB. Roy Fleischmann has received research grants and/or consulting fees from AbbVie, ACEA, Amgen, AstraZeneca, Bristol Myers Squibb, Centrexion, Eli Lilly, EMD Serono, Genentech, Gilead, GlaxoSmithKline, Janssen, Merck, Novartis, Pfizer, Regeneron, Roche, Samsung, Sandoz, Sanofi Genzyme, Selecta, and UCB.

Compliance with Ethics Guidelines

This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors.

Data Availability

Qualified researchers may request access to patient-level data and related documents (including, e.g., the clinical study report, study protocol with any amendments, blank case report form, statistical analysis plan and data set specifications). Patient-level data will be anonymized and study documents will be redacted to protect the privacy of trial participants. Further details on Sanofi’s data sharing criteria, eligible studies and process for requesting access can be found at: https://vivli.org.