Deeks ED. Ticagrelor: a review of its use in the management of acute coronary syndromes. Drugs. 2011;71(7):909–33.

Article  CAS  Google Scholar 

Mahaffey KW, Held C, Wojdyla DM, et al. Ticagrelor effects on myocardial infarction and the impact of event adjudication in the PLATO (Platelet Inhibition and Patient Outcomes) trial. J Am Coll Cardiol. 2014;63(15):1493–9.

Article  CAS  Google Scholar 

Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361(11):1045–57.

Article  CAS  Google Scholar 

Andell P, James SK, Cannon CP, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes and chronic obstructive pulmonary disease: an analysis from the platelet inhibition and Patient Outcomes (PLATO) Trial. J Am Heart Assoc. 2015;4(10): e002490.

Article  Google Scholar 

Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC Guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;64(24):e139–228.

Article  Google Scholar 

Levine GN, Bates ER, Bittl JA, et al. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines: an update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention, 2011 ACCF/AHA guideline for coronary artery bypass graft surgery, 2012 CC/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease, 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction, 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes, and 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery. Circulation. 2016;134(10):e123-155.

Google Scholar 

Collet J-P, Thiele H. The ‘Ten Commandments’ for the 2020 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST segment elevation. Eur Heart J. 2020;41(37):3495–7.

Article  Google Scholar 

Sheiner LB, Ludden TM. Population pharmacokinetics/dynamics. Annu Rev Pharmacol Toxicol. 1992;32:185–209.

Article  CAS  Google Scholar 

Li J, Tang W, Storey RF, Husted S, Teng R. Population pharmacokinetics of ticagrelor in patients with acute coronary syndromes. Int J Clin Pharmacol Ther. 2016;54(9):666–74.

Article  Google Scholar 

Röshammar D, Bergstrand M, Andersson T, Storey RF, Hamrén B. Population pharmacokinetics of ticagrelor and AR-C124910XX in patients with prior myocardial infarction. Int J Clin Pharmacol Ther. 2017;55(5):416–24.

Article  Google Scholar 

Zhang M, You X, Ke M, Jiao Z, Wu H, Huang P, Lin C. Prediction of ticagrelor and its active metabolite in liver cirrhosis populations using a physiologically based pharmacokinetic model involving pharmacodynamics. J Pharm Sci. 2019;108(8):2781–90.

Article  CAS  Google Scholar 

Liu S, Xue L, Shi X, Sun Z, Zhu Z, Zhang X, Tian X. Population pharmacokinetics and pharmacodynamics of ticagrelor and AR-C124910XX in Chinese healthy male subjects. Eur J Clin Pharmacol. 2018;74(6):745–54.

Article  CAS  Google Scholar 

Amilon C, Niazi M, Berggren A, Åstrand M, Hamrén B. Population pharmacokinetics/pharmacodynamics of ticagrelor in children with sickle cell disease. Clin Pharmacokinet. 2019;58(10):1295–307.

Article  CAS  Google Scholar 

Åstrand M, Amilon C, Röshammar D, Himmelmann A, Angiolillo DJ, Storey RF, Gurbel PA, Bonaca MP, Hamrén B. Pharmacokinetic-pharmacodynamic modelling of platelet response to ticagrelor in stable coronary artery disease and prior myocardial infarction patients. Br J Clin Pharmacol. 2019;85(2):413–21.

Article  Google Scholar 

Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J, et al. Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the bleeding academic research consortium. Circulation. 2011;123(23):2736–47.

Article  Google Scholar 

Sillén H, Cook M, Davis P. Determination of ticagrelor and two metabolites in plasma samples by liquid chromatography and mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878:2299–306.

Article  Google Scholar 

Xiang Q, Liu Z, Mu G, Xie Q, Zhang H, Zhou S, Wang Z, Guo N, Huang J, Jiang J, Li J, Yang G, Cui Y. Effect of genetic polymorphism including NUP153 and SVEP1 on the pharmacokinetics and pharmacodynamics of ticagrelor in healthy Chinese subjects. Clin Drug Investig. 2022;42(5):447–58.

Article  CAS  Google Scholar 

Keizer RJ, Karlsson MO, Hooker A. Modeling and simulation workbench for NONMEM: tutorial on Pirana, PsN, and Xpose. CPT Pharm Syst Pharmacol. 2013;2: e50.

Article  CAS  Google Scholar 

Zhang L, Beal SL, Sheiner LB. Simultaneous vs. sequential analysis for population PK/PD data I: best-case performance. J Pharmacokinet Pharmacodyn. 2003;30(6):387–404.

Article  Google Scholar 

Liu S, Xue L, Shi X, et al. Population pharmacokinetics and pharmacodynamics of ticagrelor and AR-C124910XX in Chinese healthy male subjects. Eur J Clin Pharmacol. 2018;74(4):745–54.

Article  CAS  Google Scholar 

Rshammar D, Bergstrand M, Andersson T, et al. Population pharmacokinetics of ticagrelor and AR-C124910XX in patients with prior myocardial infarction. Int J Clin Pharmacol Ther. 2017;55(5):416.

Article  Google Scholar 

Storey RF, Angiolillo DJ, Bonaca MP, Thomas MR, Judge HM, Rollini F, et al. Platelet inhibition with ticagrelor 60 mg versus 90 mg twice daily in the PEGASUS-TIMI 54 trial. J Am Coll Cardiol. 2016;67(10):1145–54.

Article  CAS  Google Scholar 

Tantry US, Bonello L, Aradi D, Price MJ, Jeong YH, Angiolillo DJ, et al. Working Group on On-Treatment Platelet Reactivity. Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding. J Am Coll Cardiol. 2013;62(24):2261–73.

Article  CAS  Google Scholar 

Barbieri L, Verdoia M, Pergolini P, Nardin M, Rolla R, Marino P, et al. Novara Atherosclerosis Study Group (NAS). Uric acid and high-residual platelet reactivity in patients treated with clopidogrel or ticagrelor. Nutr Metab Cardiovasc Dis. 2016;26(4):352–8.

Article  CAS  Google Scholar 

Venetsanos D, Sederholm Lawesson S, Swahn E, Alfredsson J. Chewed ticagrelor tablets provide faster platelet inhibition compared to integral tablets: the inhibition of platelet aggregation after administration of three different ticagrelor formulations (IPAAD-Tica) study, a randomised controlled trial. Thromb Res. 2017;149:88–94.

Article  CAS  Google Scholar 

Dobesh PP, Oestreich JH. Ticagrelor: pharmacokinetics, pharmacodynamics, clinical efficacy, and safety. Pharmacotherapy. 2015;34(10):1077–90.

Article  Google Scholar 

Yuan D, Shi X, Gao L, Wan G, Zhang H, Yang Y, et al. Identification of potential biological factors affecting the treatment of ticagrelor after percutaneous coronary intervention in the Chinese population. Pharmgenomics Pers Med. 2022;15:29–43.

Google Scholar 

Conti V, Corbi G, Manzo V, Sellitto C, Iannello F, Esposito S, De Bellis E, Iannaccone T, Filippelli A. The role of pharmacogenetics in antithrombotic therapy management: new achievements and barriers yet to overcome. Curr Med Chem. 2021;28(32):6675–703.

Article  CAS  Google Scholar