A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling

Hill NR, Fatoba ST, Oke JL, Hirst JA, O’Callaghan CA, Lasserson DS, et al. Global prevalence of chronic kidney disease—a systematic review and meta-analysis. PLoS ONE. 2016;11(7): e0158765.

Article  Google Scholar 

Moody WE, Chue CD, Inston NG, Edwards NC, Steeds RP, Ferro CJ, et al. Understanding the effects of chronic kidney disease on cardiovascular risk: are there lessons to be learnt from healthy kidney donors? J Hum Hypertens. 2012;26(3):141–8.

Article  CAS  Google Scholar 

Chen TK, Knicely DH, Grams ME. Chronic kidney disease diagnosis and management: a review. JAMA. 2019;322(13):1294–304.

Article  CAS  Google Scholar 

Heerspink HJL, Stefansson BV, Correa-Rotter R, Chertow GM, Greene T, Hou FF, et al. Dapagliflozin in patients with chronic kidney disease. N Engl J Med. 2020;383(15):1436–46.

Article  CAS  Google Scholar 

Meng XM, Nikolic-Paterson DJ, Lan HY. TGF-beta: the master regulator of fibrosis. Nat Rev Nephrol. 2016;12(6):325–38.

Article  CAS  Google Scholar 

Voelker J, Berg PH, Sheetz M, Duffin K, Shen T, Moser B, et al. Anti-TGF-beta1 antibody therapy in patients with diabetic nephropathy. J Am Soc Nephrol. 2017;28(3):953–62.

Article  CAS  Google Scholar 

de Kretser DM, O’Hehir RE, Hardy CL, Hedger MP. The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair. Mol Cell Endocrinol. 2012;359(1–2):101–6.

Article  Google Scholar 

Tsuchida K, Nakatani M, Hitachi K, Uezumi A, Sunada Y, Ageta H, et al. Activin signaling as an emerging target for therapeutic interventions. Cell Commun Signal. 2009;7:15.

Article  Google Scholar 

Hedger MP, de Kretser DM. The activins and their binding protein, follistatin-diagnostic and therapeutic targets in inflammatory disease and fibrosis. Cytokine Growth Factor Rev. 2013;24(3):285–95.

Article  CAS  Google Scholar 

Mehta N, Krepinsky JC. The emerging role of activins in renal disease. Curr Opin Nephrol Hypertens. 2020;29(1):136–44.

Article  CAS  Google Scholar 

Sun Y, Cai H, Ge J, Shao F, Huang Z, Ding Z, et al. Tubule-derived INHBB promotes interstitial fibroblast activation and renal fibrosis. J Pathol. 2022;256(1):25–37.

Article  CAS  Google Scholar 

Schmitt J, Hotten G, Jenkins NA, Gilbert DJ, Copeland NG, Pohl J, et al. Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene. Genomics. 1996;32(3):358–66.

Article  CAS  Google Scholar 

Hashimoto O, Tsuchida K, Ushiro Y, Hosoi Y, Hoshi N, Sugino H, et al. cDNA cloning and expression of human activin betaE subunit. Mol Cell Endocrinol. 2002;194(1–2):117–22.

Article  CAS  Google Scholar 

Iemura S, Yamamoto TS, Takagi C, Uchiyama H, Natsume T, Shimasaki S, et al. Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo. Proc Natl Acad Sci USA. 1998;95(16):9337–42.

Article  CAS  Google Scholar 

Wada W, Kuwano H, Hasegawa Y, Kojima I. The dependence of transforming growth factor-beta-induced collagen production on autocrine factor activin A in hepatic stellate cells. Endocrinology. 2004;145(6):2753–9.

Article  CAS  Google Scholar 

Aoki F, Kurabayashi M, Hasegawa Y, Kojima I. Attenuation of bleomycin-induced pulmonary fibrosis by follistatin. Am J Respir Crit Care Med. 2005;172(6):713–20.

Article  Google Scholar 

Yamashita S, Maeshima A, Kojima I, Nojima Y. Activin A is a potent activator of renal interstitial fibroblasts. J Am Soc Nephrol. 2004;15(1):91–101.

Article  CAS  Google Scholar 

Mehta N, Zhang D, Li R, Wang T, Gava A, Parthasarathy P, et al. Caveolin-1 regulation of Sp1 controls production of the antifibrotic protein follistatin in kidney mesangial cells. Cell Commun Signal. 2019;17(1):37.

Article  Google Scholar 

Gaedeke J, Boehler T, Budde K, Neumayer HH, Peters H. Glomerular activin A overexpression is linked to fibrosis in anti-Thy1 glomerulonephritis. Nephrol Dial Transplant. 2005;20(2):319–28.

Article  CAS  Google Scholar 

Li N, Yang Y, He K, Zhang F, Zhao L, Zhou W, et al. Single-molecule imaging reveals the activation dynamics of intracellular protein Smad3 on cell membrane. Sci Rep. 2016;6:33469.

Article  CAS  Google Scholar 

Kakoki M, Pochynyuk OM, Hathaway CM, Tomita H, Hagaman JR, Kim HS, et al. Primary aldosteronism and impaired natriuresis in mice underexpressing TGFbeta1. Proc Natl Acad Sci USA. 2013;110(14):5600–5.

Article  CAS  Google Scholar 

Zhang Z, Wang J, Chen Y, Suo L, Chen H, Zhu L, et al. Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway. Cell Commun Signal. 2019;17(1):1–13.

Article  Google Scholar 

Vizan P, Miller DS, Gori I, Das D, Schmierer B, Hill CS. Controlling long-term signaling: receptor dynamics determine attenuation and refractory behavior of the TGF-beta pathway. Sci Signal. 2013;6(305):ra106.

Article  Google Scholar 

Koli KM, Arteaga CL. Processing of the transforming growth factor beta type I and II receptors. Biosynthesis and ligand-induced regulation. J Biol Chem. 1997;272(10):6423–37.

Article  CAS  Google Scholar 

Elberg G, Chen L, Elberg D, Chan MD, Logan CJ, Turman MA. MKL1 mediates TGF-beta1-induced alpha-smooth muscle actin expression in human renal epithelial cells. Am J Physiol Renal Physiol. 2008;294(5):F1116–28.

Article  CAS  Google Scholar 

Gasparics A, Sebe A. MRTFs- master regulators of EMT. Dev Dyn. 2018;247(3):396–404.

Article  Google Scholar 

Hathaway CK, Gasim AM, Grant R, Chang AS, Kim HS, Madden VJ, et al. Low TGFbeta1 expression prevents and high expression exacerbates diabetic nephropathy in mice. Proc Natl Acad Sci USA. 2015;112(18):5815–20.

Article  CAS  Google Scholar 

Leelahavanichkul A, Yan Q, Hu X, Eisner C, Huang Y, Chen R, et al. Angiotensin II overcomes strain-dependent resistance of rapid CKD progression in a new remnant kidney mouse model. Kidney Int. 2010;78(11):1136–53.

Article  CAS  Google Scholar 

Eddy AA, Lopez-Guisa JM, Okamura DM, Yamaguchi I. Investigating mechanisms of chronic kidney disease in mouse models. Pediatr Nephrol. 2012;27(8):1233–47.

Article  Google Scholar 

Nordholm A, Mace ML, Gravesen E, Hofman-Bang J, Morevati M, Olgaard K, et al. Klotho and activin A in kidney injury: plasma Klotho is maintained in unilateral obstruction despite no upregulation of Klotho biosynthesis in the contralateral kidney. Am J Physiol Renal Physiol. 2018;314(5):F753–62.

Article  CAS  Google Scholar 

Staudacher JJ, Bauer J, Jana A, Tian J, Carroll T, Mancinelli G, et al. Activin signaling is an essential component of the TGF-beta induced pro-metastatic phenotype in colorectal cancer. Sci Rep. 2017;7(1):5569.

Article  Google Scholar 

Yuan C, Ni L, Wu X. Activin A activation drives renal fibrosis through the STAT3 signaling pathway. Int J Biochem Cell Biol. 2021;134: 105950.

Article  CAS  Google Scholar 

Yu L, Border WA, Huang Y, Noble NA. TGF-beta isoforms in renal fibrogenesis. Kidney Int. 2003;64(3):844–56.

Article  CAS  Google Scholar 

Menke A, Geerling I, Giehl K, Vogelmann R, Reinshagen M, Adler G. Transforming growth factor-beta-induced upregulation of transforming growth factor-beta receptor expression in pancreatic regeneration. Biochim Biophys Acta. 1999;1449(2):178–85.

Article  CAS  Google Scholar 

Duan D, Derynck R. Transforming growth factor-beta (TGF-beta)-induced up-regulation of TGF-beta receptors at the cell surface amplifies the TGF-beta response. J Biol Chem. 2019;294(21):8490–504.

Article  CAS  Google Scholar 

Ishikawa M, Nishijima N, Shiota J, Sakagami H, Tsuchida K, Mizukoshi M, et al. Involvement of the serum response factor coactivator megakaryoblastic leukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons. J Biol Chem. 2010;285(43):32734–43.

Article  CAS  Google Scholar 

Fintha A, Gasparics A, Fang L, Erdei Z, Hamar P, Mozes MM, et al. Characterization and role of SCAI during renal fibrosis and epithelial-to-mesenchymal transition. Am J Pathol. 2013;182(2):388–400.

Article  CAS  Google Scholar 

Hu J, Wang X, Wei SM, Tang YH, Zhou Q, Huang CX. Activin A stimulates the proliferation and differentiation of cardiac fibroblasts via the ERK1/2 and p38-MAPK pathways. Eur J Pharmacol. 2016;789:319–27.

Article  CAS  Google Scholar 

Jiang L, Qi Y, Kong X, Wang R, Qi J, Lin F, et al. Activin A as a novel chemokine induces migration of L929 fibroblasts by ERK signaling in microfluidic devices. Front Cell Dev Biol. 2021;9: 660316.

Article  Google Scholar 

Dean M, Davis DA, Burdette JE. Activin A stimulates migration of the fallopian tube epithelium, an origin of high-grade serous ovarian cancer, through non-canonical signaling. Cancer Lett. 2017;391:114–24.

Article  CAS  Google Scholar 

Meng XM, Huang XR, Chung AC, Qin W, Shao X, Igarashi P, et al. Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis. J Am Soc Nephrol. 2010;21(9):1477–87.

Article  CAS  Google Scholar 

Pande HO, Tesfaye D, Hoelker M, Gebremedhn S, Held E, Neuhoff C, et al. MicroRNA-424/503 cluster members regulate bovine granulosa cell proliferation and cell cycle progression by targeting SMAD7 gene through activin signalling pathway. J Ovarian Res. 2018;11(1):34.

Article  Google Scholar 

Chung AC, Huang XR, Zhou L, Heuchel R, Lai KN, Lan HY. Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice. Nephrol Dial Transplant. 2009;24(5):1443–54.

Article  CAS  Google Scholar 

Hagos EG, Dougan ST. Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafish. BMC Dev Biol. 2007;7:22.

留言 (0)

沒有登入
gif