Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660

Article  Google Scholar 

Jemal, A., Ward, E. M., Johnson, C. J., Cronin, K. A., Ma, J., Ryerson, B., et al. (2017). Annual report to the nation on the status of cancer, 1975–2014, Featuring Survival. JNCI: Journal of the National Cancer Institute, 109(9), https://doi.org/10.1093/jnci/djx030.

Villanueva, A. (2019). Hepatocellular Carcinoma. New England Journal of Medicine, 380(15), 1450–1462. https://doi.org/10.1056/NEJMra1713263

Article  CAS  Google Scholar 

In der Stroth, L., Tharehalli, U., Gunes, C., & Lechel, A. (2020). Telomeres and telomerase in the development of liver cancer. Cancers (Basel), 12(8), https://doi.org/10.3390/cancers12082048.

Delire, B., & Starkel, P. (2015). The Ras/MAPK pathway and hepatocarcinoma: Pathogenesis and therapeutic implications. European Journal of Clinical Investigation, 45(6), 609–623. https://doi.org/10.1111/eci.12441

Article  CAS  Google Scholar 

Chen, C., & Wang, G. (2015). Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy. World Journal of Hepatology, 7(15), 1964–1970. https://doi.org/10.4254/wjh.v7.i15.1964

Article  Google Scholar 

Kudo, M. (2011). Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma. Digestive Diseases, 29(3), 289–302. https://doi.org/10.1159/000327562

Article  Google Scholar 

Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., et al. (1997). hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell, 90(4), 785–795. https://doi.org/10.1016/s0092-8674(00)80538-3

Article  CAS  Google Scholar 

Ramakrishna, G., Rastogi, A., Trehanpati, N., Sen, B., Khosla, R., & Sarin, S. K. (2013). From cirrhosis to hepatocellular carcinoma: New molecular insights on inflammation and cellular senescence. Liver Cancer, 2(3–4), 367–383. https://doi.org/10.1159/000343852

Article  CAS  Google Scholar 

Wu, Y., Zhang, J., Zhang, H., & Zhai, Y. (2016). Hepatitis B virus X protein mediates yes-associated protein 1 upregulation in hepatocellular carcinoma. Oncology Letters, 12(3), 1971–1974. https://doi.org/10.3892/ol.2016.4885

Article  CAS  Google Scholar 

Wang, Y., Han, C., Lu, L., Magliato, S., & Wu, T. (2013). Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. Hepatology, 58(3), 995–1010. https://doi.org/10.1002/hep.26394

Article  CAS  Google Scholar 

Chow, A. K., Yau, S. W., & Ng, L. (2020). Novel molecular targets in hepatocellular carcinoma. World Journal of Clinical Oncology, 11(8), 589–605. https://doi.org/10.5306/wjco.v11.i8.589

Article  Google Scholar 

Singal, A. G., Lampertico, P., & Nahon, P. (2020). Epidemiology and surveillance for hepatocellular carcinoma: New trends. Journal of Hepatology, 72(2), 250–261. https://doi.org/10.1016/j.jhep.2019.08.025

Article  CAS  Google Scholar 

McGlynn, K. A., Petrick, J. L., & El-Serag, H. B. (2021). Epidemiology of hepatocellular carcinoma. Hepatology, 73(Suppl 1), 4–13. https://doi.org/10.1002/hep.31288

Article  CAS  Google Scholar 

Global Burden of Disease Liver Cancer, C, Akinyemiju, T., Abera, S., Ahmed, M., Alam, N., Alemayohu, M. A., et al. (2017). The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: results from the Global Burden of Disease Study 2015. JAMA Oncology, 3(12), 1683–1691. https://doi.org/10.1001/jamaoncol.2017.3055

Article  Google Scholar 

Sangiovanni, A., Prati, G. M., Fasani, P., Ronchi, G., Romeo, R., Manini, M., et al. (2006). The natural history of compensated cirrhosis due to hepatitis C virus: A 17-year cohort study of 214 patients. Hepatology, 43(6), 1303–1310. https://doi.org/10.1002/hep.21176

Article  Google Scholar 

Ioannou, G. N., Splan, M. F., Weiss, N. S., McDonald, G. B., Beretta, L., & Lee, S. P. (2007). Incidence and predictors of hepatocellular carcinoma in patients with cirrhosis. Clin Gastroenterol Hepatol, 5(8), 938–945, 945 e931–934, https://doi.org/10.1016/j.cgh.2007.02.039.

Maucort-Boulch, D., de Martel, C., Franceschi, S., & Plummer, M. (2018). Fraction and incidence of liver cancer attributable to hepatitis B and C viruses worldwide. International Journal of Cancer, 142(12), 2471–2477. https://doi.org/10.1002/ijc.31280

Article  CAS  Google Scholar 

Alfaiate, D., Clement, S., Gomes, D., Goossens, N., & Negro, F. (2020). Chronic hepatitis D and hepatocellular carcinoma: A systematic review and meta-analysis of observational studies. Journal of Hepatology, 73(3), 533–539. https://doi.org/10.1016/j.jhep.2020.02.030

Article  Google Scholar 

Beguelin, C., Moradpour, D., Sahli, R., Suter-Riniker, F., Luthi, A., Cavassini, M., et al. (2017). Hepatitis delta-associated mortality in HIV/HBV-coinfected patients. Journal of Hepatology, 66(2), 297–303. https://doi.org/10.1016/j.jhep.2016.10.007

Article  Google Scholar 

Chen, C. J., Wang, L. Y., Lu, S. N., Wu, M. H., You, S. L., Zhang, Y. J., et al. (1996). Elevated aflatoxin exposure and increased risk of hepatocellular carcinoma. Hepatology, 24(1), 38–42. https://doi.org/10.1002/hep.510240108

Article  CAS  Google Scholar 

Chu, Y. J., Yang, H. I., Wu, H. C., Liu, J., Wang, L. Y., Lu, S. N., et al. (2017). Aflatoxin B1 exposure increases the risk of cirrhosis and hepatocellular carcinoma in chronic hepatitis B virus carriers. International Journal of Cancer, 141(4), 711–720. https://doi.org/10.1002/ijc.30782

Article  CAS  Google Scholar 

Chen, J., Zhu, J., Wang, G., Groopman, J. D., & Kensler, T. W. (2019). Qidong: a crucible for studies on liver cancer etiology and prevention. Cancer Biology and Medicine, 16(1), 24–37. https://doi.org/10.20892/j.issn.2095-3941.2018.0394

Article  Google Scholar 

Yu, S. Z. (1995). Primary prevention of hepatocellular carcinoma. Journal of Gastroenterology and Hepatology, 10(6), 674–682. https://doi.org/10.1111/j.1440-1746.1995.tb01370.x

Article  CAS  Google Scholar 

Mancebo, A., Gonzalez-Dieguez, M. L., Cadahia, V., Varela, M., Perez, R., Navascues, C. A., et al. (2013). Annual incidence of hepatocellular carcinoma among patients with alcoholic cirrhosis and identification of risk groups. Clinical Gastroenterology and Hepatology, 11(1), 95–101. https://doi.org/10.1016/j.cgh.2012.09.007

Article  Google Scholar 

Trichopoulos, D., Bamia, C., Lagiou, P., Fedirko, V., Trepo, E., Jenab, M., et al. (2011). Hepatocellular carcinoma risk factors and disease burden in a European cohort: A nested case-control study. Journal of the National Cancer Institute, 103(22), 1686–1695. https://doi.org/10.1093/jnci/djr395

Article  Google Scholar 

Chen, H. P., Shieh, J. J., Chang, C. C., Chen, T. T., Lin, J. T., Wu, M. S., et al. (2013). Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: Population-based and in vitro studies. Gut, 62(4), 606–615. https://doi.org/10.1136/gutjnl-2011-301708

Article  CAS  Google Scholar 

Arase, Y., Kobayashi, M., Suzuki, F., Suzuki, Y., Kawamura, Y., Akuta, N., et al. (2013). Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C. Hepatology, 57(3), 964–973. https://doi.org/10.1002/hep.26087

Article  CAS  Google Scholar 

Koh, J. C., Loo, W. M., Goh, K. L., Sugano, K., Chan, W. K., Chiu, W. Y., et al. (2016). Asian consensus on the relationship between obesity and gastrointestinal and liver diseases. Journal of Gastroenterology and Hepatology, 31(8), 1405–1413. https://doi.org/10.1111/jgh.13385

Article  Google Scholar 

Seyda Seydel, G., Kucukoglu, O., Altinbasv, A., Demir, O. O., Yilmaz, S., Akkiz, H., et al. (2016). Economic growth leads to increase of obesity and associated hepatocellular carcinoma in developing countries. Annals of Hepatology, 15(5), 662–672. https://doi.org/10.5604/16652681.1212316

Article  CAS  Google Scholar 

Atkins, J. L., Pilling, L. C., Masoli, J. A. H., Kuo, C. L., Shearman, J. D., Adams, P. C., et al. (2020). Association of Hemochromatosis HFE p. C282Y Homozygosity With Hepatic Malignancy. JAMA, 324(20), 2048–2057. https://doi.org/10.1001/jama.2020.21566

Article  CAS  Google Scholar 

Elmberg, M., Hultcrantz, R., Ekbom, A., Brandt, L., Olsson, S., Olsson, R., et al. (2003). Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives. Gastroenterology, 125(6), 1733–1741. https://doi.org/10.1053/j.gastro.2003.09.035

Article  Google Scholar 

Stewart, M. F. (2012). Review of hepatocellular cancer, hypertension and renal impairment as late complications of acute porphyria and recommendations for patient follow-up. Journal of Clinical Pathology, 65(11), 976–980. https://doi.org/10.1136/jclinpath-2012-200791

Article  Google Scholar 

Linet, M. S., Gridley, G., Nyren, O., Mellemkjaer, L., Olsen, J. H., Keehn, S., et al. (1999). Primary liver cancer, other malignancies, and mortality risks following porphyria: A cohort study in Denmark and Sweden. American Journal of Epidemiology, 149(11), 1010–1015. https://doi.org/10.1093/oxfordjournals.aje.a009745

Article  CAS  Google Scholar 

Baravelli, C. M., Sandberg, S., Aarsand, A. K., & Tollanes, M. C. (2019). Porphyria cutanea tarda increases risk of hepatocellular carcinoma and premature death: A nationwide cohort study. Orphanet Journal of Rare Diseases, 14(1), 77. https://doi.org/10.1186/s13023-019-1051-3

Article  Google Scholar 

Cha, C., & Dematteo, R. P. (2005). Molecular mechanisms in hepatocellular carcinoma development. Best Practice and Research Clinical Gastroenterology, 19(1), 25–37. https://doi.org/10.1016/j.bpg.2004.11.005

Article  CAS  Google Scholar 

Neuveut, C., Wei, Y., & Buendia, M. A. (2010). Mechanisms of HBV-related hepatocarcinogenesis. Journal of Hepatology, 52(4), 594–604. https://doi.org/10.1016/j.jhep.2009.10.033

Article  CAS  Google Scholar 

Diaz, G., Engle, R. E., Tice, A., Melis, M., Montenegro, S., Rodriguez-Canales, J., et al. (2018). Molecular signature and mechanisms of hepatitis D virus-associated hepatocellular carcinoma. Molecular Cancer Research, 16(9), 1406–1419. https://doi.org/10.1158/1541-7786.MCR-18-0012

Article  CAS  Google Scholar 

Nault, J. C., & Villanueva, A. (2015). Intratumor molecular and phenotypic diversity in hepatocellular carcinoma. Clinical Cancer Research, 21(8), 1786–1788. https://doi.org/10.1158/1078-0432.CCR-14-2602

Article  CAS  Google Scholar 

Kawai-Kitahata, F., Asahina, Y., Tanaka, S., Kakinuma, S., Murakawa, M., Nitta, S., et al. (2016). Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. Journal of Gastroenterology, 51(5), 473–486. https://doi.org/10.1007/s00535-015-1126-4

Article  CAS  Google Scholar 

Bruix, J., Han, K. H., Gores, G., Llovet, J. M., & Mazzaferro, V. (2015). Liver cancer: Approaching a personalized care. Journal of Hepatology, 62(1 Suppl), S144-156. https://doi.org/10.1016/j.jhep.2015.02.007

Article  Google Scholar 

Guichard, C., Amaddeo, G., Imbeaud, S., Ladeiro, Y., Pelletier, L., Maad, I. B., et al. (2012). Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nature Genetics, 44(6), 694–698. https://doi.org/10.1038/ng.2256

Article  CAS  Google Scholar 

Ahn, S. M., Jang, S. J., Shim, J. H., Kim, D., Hong, S. M., Sung, C. O., et al. (2014). Genomic portrait of resectable hepatocellular carcinomas: Implications of RB1 and FGF19 aberrations for patient stratification. Hepatology, 60(6), 1972–1982. https://doi.org/10.1002/hep.27198

Article  CAS 

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