The authors thank the patients and their families for their participation. The opinions and assertions expressed herein are those of the authors and are not to be construed as reflecting the views of Uniformed Services University of the Health Sciences or the United States Department of Defense.

Bradly M. Bauman4, Gina Dabbah-Krancher4, Xijun Zhang5,6, Gauthaman Sukumar5,6, Joaquin Villar5,6, Marita Bosticardo7, Shefali Anil Samant1, Timothy James Maarup8, Jerry C. Cheng9, Neena Kapoor10, David S. Cassarino11, Joshua D. Milner12, Luigi Notarangelo7, Joseph A. Church10, Javed Sheikh1‡, Clifton L. Dalgard5,6

5The American Genome Center, Precision Medicine Initiative for Military Medical Education and Research (PRIMER), Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

6Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

7Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

8Department of Genetics, Kaiser Permanente Downey Medical Centre, Downey, CA, USA

9Department of Pediatrics, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA

10Department of Pediatrics, Keck School of Medicine, University of Southern California, Children’s Hospital Los Angeles, Los Angeles, CA, USA

11Department of Pathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA

12Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA