Metabolic reprogramming in tumour cells is known to dampen antitumour immunity, however, whether immunosurveillance can guide tumour metabolism remained unexplored. Tsai et al. now show that interferon-γ (IFNγ), released during T cell-mediated immunosurveillance, drives MYC-dependent metabolic reprogramming in tumour cells to support their proliferation and immune escape.