Explainable synthetic image generation to improve risk assessment of rare pediatric heart transplant rejection

Keywords

Image classification

Image generation

Multiple instance learning

Explainable artificial intelligence

Cardiac pathology

Whole-slide imaging

Data Availability

A prospective observational study (DNA-Based Transplant Rejection Test [DTRT]) was conducted among 7 established heart transplant centers, each obtaining local Institutional Review Board (CHW 10/83, GC 111, and CTSI 906) approval. All experiments were performed in accordance with relevant guidelines and regulations; informed consent was obtained from all partici- pants. All research data are de-identified and securely stored. Data access is limited to approved study personnel.

© 2023 Published by Elsevier Inc.

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