Heins N, Malatesta P, Cecconi F, Nakafuku M, Tucker KL, Hack MA, et al. Glial cells generate neurons: the role of the transcription factor Pax6. Nat Neurosci. 2002;5:308–15.

Article  CAS  Google Scholar 

Xue Y, Ouyang K, Huang J, Zhou Y, Ouyang H, Li H, et al. Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell. 2013;152:82–96.

Article  CAS  Google Scholar 

Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, et al. Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature. 2020;582:550–6.

Article  CAS  Google Scholar 

Zhou H, Su J, Hu X, Zhou C, Li H, Chen Z, et al. Glia-to-neuron conversion by CRISPR-CasRx alleviates symptoms of neurological disease in mice. Cell. 2020;181:590–603.e16.

Article  CAS  Google Scholar 

Maimon R, Chillon-Marinas C, Snethlage CE, Singhal SM, McAlonis-Downes M, Ling K, et al. Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB. Nat. Neurosci. 2021;24:1089–99.

Article  CAS  Google Scholar 

Wang LL, Serrano C, Zhong X, Ma S, Zou Y, Zhang CL. Revisiting astrocyte to neuron conversion with lineage tracing in vivo. Cell. 2021;184:5465–81.e16.

Article  CAS  Google Scholar 

Xie Y, Zhou J, Chen B. Critical examination of Ptbp1-mediated glia-to-neuron conversion in the mouse retina. Cell Rep. 2022;39:110960.

Article  CAS  Google Scholar 

Chen W, Zheng Q, Huang Q, Ma S, Li M. Repressing PTBP1 fails to convert reactive astrocytes to dopaminergic neurons in a 6-hydroxydopamine mouse model of Parkinson’s disease. eLife. 2022;11:e75636.

Article  CAS  Google Scholar 

Hoang T, Kim DW, Appel H, Pannullo NA, Leavey P, Ozawa M, et al. Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina. Cell Rep. 2022;39:110849.

Article  CAS  Google Scholar 

Leib D, Chen YH, Monteys AM, Davidson BL. Limited astrocyte-to-neuron conversion in the mouse brain using NeuroD1 overexpression. Mol Ther J Am Soc Gene Ther. 2022;30:982–6.

Article  CAS  Google Scholar 

Chan KY, Jang MJ, Yoo BB, Greenbaum A, Ravi N, Wu WL, et al. Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems. Nat. Neurosci. 2017;20:1172–9.

Article  CAS  Google Scholar 

Xu C, Zhou Y, Xiao Q, He B, Geng G, Wang Z, et al. Programmable RNA editing with compact CRISPR-Cas13 systems from uncultivated microbes. Nat. Methods. 2021;18:499–506.

Article  CAS  Google Scholar 

Lee Y, Messing A, Su M, Brenner M. GFAP promoter elements required for region-specific and astrocyte-specific expression. Glia. 2008;56:481–93.

Article  Google Scholar 

He B, Peng W, Huang J, Zhang H, Zhou Y, Yang X, et al. Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver. Protein Cell. 2020;11:518–24.

Article  CAS  Google Scholar 

Zhou C, Hu X, Tang C, Liu W, Wang S, Zhou Y, et al. CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration. Natl Sci Rev. 2020;7:835–7.

Article  CAS  Google Scholar 

Powell JE, Lim CKW, Krishnan R, McCallister TX, Saporito-Magrina C, Zeballos MA, et al. Targeted gene silencing in the nervous system with CRISPR-Cas13. Sci Adv. 2022;8:eabk2485.

Article  CAS  Google Scholar 

Tong H, Huang J, Xiao Q, He B, Dong X, Liu Y, et al. High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects. Nat. Biotechnol. 2023;41:108–19.

Gao Y, Fang K, Yan Z, Zhang H, Geng G, Wu W, et al. Develop an efficient and specific AAV-based labeling system for Muller glia in mice. Sci Rep. 2022;12:22410.

Vuong JK, Lin CH, Zhang M, Chen L, Black DL, Zheng S. PTBP1 and PTBP2 serve both specific and redundant functions in neuronal Pre-mRNA Splicing. Cell Rep. 2016;17:2766–75.

Article  CAS  Google Scholar 

Yang RY, Chai R, Pan JY, Bao JY, Xia PH, Wang YK, et al. Knockdown of polypyrimidine tract binding protein facilitates motor function recovery after spinal cord injury. Neural Regen Res. 2023;18:396–403.