Nail Amyloidoma: Two Case Reports of a New Entity

Novel Insights from Clinical Practice

Bonito F.Kolivras A.b· Sass U.b· Richert B.c

Author affiliations

aDepartment of Dermatovenereology, Hospital Garcia de Orta E.P.E., Almada, Portugal
bDepartment of Dermatology, Saint-Pierre Hospital, Université Libre de Bruxelles, Brussels, Belgium
cDepartment of Dermatology, Saint-Pierre, Brugmann and Queen Fabiola Children’s University Hospitals, Université Libre de Bruxelles, Brussels, Belgium

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Article / Publication Details

First-Page Preview

Abstract of Novel Insights from Clinical Practice

Received: October 07, 2022
Accepted: January 05, 2023
Published online: February 01, 2023

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)

For additional information: https://www.karger.com/SAD

Abstract

Introduction: Amyloidosis is a group of diseases characterized by extracellular deposits of abnormal insoluble proteins in different tissues. Amyloidoma is a localized tumoral deposit of amyloid in the absence of systemic amyloidosis, and it has been described in different anatomic sites. We report two cases of amyloidoma in the nail unit and provide insights into this recently described entity. Case Presentation: Both cases presented as an asymptomatic, slowly growing nodule underneath the distal nail bed of a toe with associated onycholysis. Histopathology was characterized in both patients by the presence of deposits of Congo red-positive, homogeneous, amorphous, and eosinophilic material within the dermis and subcutaneous tissue admixed with aggregates of plasma cells. In both cases, an extensive workup excluded systemic amyloidosis. Treatment was based on local excision, and no local recurrence or progression to systemic amyloidosis was observed at 1 year of follow-up. Conclusion: These are the first reports of amyloidomas of the nail unit. The clinical and histopathological presentations parallel those of an amyloidoma affecting the skin. Local excision seems to be an efficient treatment modality, but long-term follow-up is warranted in order to exclude recurrence, an associated marginal B-cell lymphoma, or progression to systemic amyloid L amyloidosis.

© 2023 S. Karger AG, Basel

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First-Page Preview

Abstract of Novel Insights from Clinical Practice

Received: October 07, 2022
Accepted: January 05, 2023
Published online: February 01, 2023

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 2296-9195 (Print)
eISSN: 2296-9160 (Online)

For additional information: https://www.karger.com/SAD

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