Plasma derived extracellular vesicle biomarkers of microglia activation in an experimental stroke model

Perry VH, Hume DA, Gordon S. Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain. Neuroscience. 1985;15(2):313–26.

Article  CAS  Google Scholar 

Grenier Y, Ruijs TC, Robitaille Y, Olivier A, Antel JP. Immunohistochemical studies of adult human glial cells. J Neuroimmunol. 1989;21(2–3):103–15.

Article  CAS  Google Scholar 

Nakajima K, Kohsaka S. Microglia: activation and their significance in the central nervous system. J Biochem. 2001;130(2):169–75. https://doi.org/10.1093/oxfordjournals.jbchem.a002969.

Article  CAS  Google Scholar 

Masuda T, Sankowski R, Staszewski O, Prinz M. Microglia Heterogeneity in the Single-Cell Era. Cell Rep. 2020;30(5):1271–81. https://doi.org/10.1016/j.celrep.2020.01.010.

Article  CAS  Google Scholar 

Walker DG, Lue LF. Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains. Alzheimer’s Res Ther. 2015;7(1):1–9. https://doi.org/10.1186/s13195-015-0139-9.

Article  CAS  Google Scholar 

Jiang X, He H, Mo L, Liu Q, Yang F, Zhou Y, et al. Mapping the plasticity of morphology, molecular properties and function in mouse primary microglia. Front Cell Neurosci. 2022;15(January):1–19.

CAS  Google Scholar 

Schilling M, Besselmann M, Leonhard C, Mueller M, Ringelstein EB, Kiefer R. Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice. Exp Neurol. 2003;183(1):25–33.

Article  Google Scholar 

Cotrina ML, Lou N, Tome-Garcia J, Goldman J, Nedergaard M. Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke. Neuroscience. 2017;343:483–94. https://doi.org/10.1016/j.neuroscience.2016.12.012.

Article  CAS  Google Scholar 

Liu X, Liu J, Zhao S, Zhang H, Cai W, Cai M, et al. Interleukin-4 is essential for microglia/macrophage M2 polarization and long-term recovery after cerebral ischemia. Stroke. 2016;47(2):498–504.

Article  CAS  Google Scholar 

Schilling M, Besselmann M, Müller M, Strecker JK, Ringelstein EB, Kiefer R. Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: an investigation using green fluorescent protein transgenic bone marrow chimeric mice. Exp Neurol. 2005;196(2):290–7.

Article  CAS  Google Scholar 

Zhang Z, Chopp M, Powers C. Temporal profile of microglial response following transient (2 h) middle cerebral artery occlusion. Brain Res. 1997;744(2):189–98. https://doi.org/10.1016/S0006-8993(96)01085-2.

Article  CAS  Google Scholar 

Hanisch UKK, Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci. 2007;10(11):1387–94.

Article  CAS  Google Scholar 

Hu X, Li P, Guo Y, Wang H, Leak RK, Chen S, et al. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke. 2012;43(11):3063–70.

Article  CAS  Google Scholar 

Weishaupt N, Zhang A, Deziel RA, Tasker RA, Whitehead SN. Prefrontal ischemia in the rat leads to secondary damage and inflammation in remote gray and white matter regions. Front Neurosci. 2016;10:81.

Article  Google Scholar 

Walberer M, Jantzen SU, Backes H, Rueger MA, Keuters MH, Neumaier B, et al. In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats. Brain Res. 2014;1581:80–8. https://doi.org/10.1016/j.brainres.2014.05.030.

Article  CAS  Google Scholar 

Walter HL, Walberer M, Rueger MA, Backes H, Wiedermann D, Hoehn M, et al. In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke. Neuroscience. 2015;292:71–80. https://doi.org/10.1016/j.neuroscience.2015.02.024.

Article  CAS  Google Scholar 

Raj D, Yin Z, Breur M, Doorduin J, Holtman IR, Olah M, et al. Increased white matter inflammation in aging- and Alzheimer’s disease. Brain. 2017;10(June):1–18.

Google Scholar 

Norden DM, Godbout JP. Microglia of the aged brain: primed to be activated and resistant to regulation. Neuropathol Appl Neurobiol. 2014;39(1):19–34.

Article  Google Scholar 

Levit A, Regis AM, Garabon JR, Oh S-H, Desai SJ, Rajakumar N, et al. Behavioural inflexibility in a comorbid rat model of striatal ischemic injury and mutant hAPP overexpression. Behav Brain Res. 2017;333:267–75.

Article  CAS  Google Scholar 

Pappata S, Levasseur M, Gunn RN, Myers R, Crouzel C, Syrota A, et al. Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195. Neurology. 2000;55(7):1052–4.

Article  CAS  Google Scholar 

Gulyás B, Tóth M, Schain M, Airaksinen A, Vas Á, Kostulas K, et al. Evolution of microglial activation in ischaemic core and peri-infarct regions after stroke: a PET study with the TSPO molecular imaging biomarker [11C]vinpocetine. J Neurol Sci. 2012;320(1–2):110–7. https://doi.org/10.1016/j.jns.2012.06.026.

Article  CAS  Google Scholar 

Thiel A, Radlinska BA, Paquette C, Sidel M, Soucy JP, Schirrmacher R, et al. The temporal dynamics of poststroke neuroinflammation: a longitudinal diffusion tensor imaging-guided PET study with 11C-PK11195 in acute subcortical stroke. J Nucl Med. 2010;51(9):1404–12.

Article  CAS  Google Scholar 

Switzer JA, Sikora A, Ergul A, Waller JL, Hess DC, Fagan SC. Minocycline prevents IL-6 increase after acute ischemic stroke. Transl Stroke Res. 2012;3(3):363–8.

Article  Google Scholar 

Fan X, Lo EH, Wang X. Effects of minocycline plus tissue plasminogen activator combination therapy after focal embolic stroke in type 1 diabetic rats. Stroke. 2013;44(3):745–52.

Article  CAS  Google Scholar 

Sandu RE, Uzoni A, Coman C, Popa-Wagner A. Cerebral ischemia in the aged. Limited anti-inflammatory efficacy of the indomethacin treatment. Rom J Morphol Embryol = Rev Roum Morphol Embryol. 2015;56(3):1111–7.

Google Scholar 

Beaino W, Janssen B, Vugts DJ, de Vries HE, Windhorst AD. Towards PET imaging of the dynamic phenotypes of microglia. Clin Exp Immunol. 2021;206(3):282–300.

Article  Google Scholar 

Al-Khishman NU, Qi Q, Roseborough AD, Levit A, Allman BL, Anazodo UC, et al. TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat. EJNMMI Res. 2020. https://doi.org/10.1186/s13550-020-00699-x.

Article  Google Scholar 

You Y, Muraoka S, Jedrychowski MP, Hu J, McQuade AK, Young-Pearse T, et al. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer’s disease brain. J Extracell Vesicles. 2022. https://doi.org/10.1002/jev2.12183.

Article  Google Scholar 

Elahi FM, Harvey D, Altendahl M, Brathaban N, Fernandes N, Casaletto KB, et al. Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans. Sci Rep. 2021;11(1):1–11. https://doi.org/10.1038/s41598-021-91759-2.

Article  CAS  Google Scholar 

Elahi FM, Casaletto KB, Altendahl M, Staffaroni AM, Fletcher E, Filshtein TJ, et al. “Liquid biopsy” of white matter hyperintensity in functionally normal elders. Front Aging Neurosci. 2018;10:343.

Article  CAS  Google Scholar 

Goetzl EJ, Mustapic M, Kapogiannis D, Eitan E, Lobach IV, Goetzl L, et al. Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease. FASEB J. 2016;30(11):3853–9.

Article  CAS  Google Scholar 

Winston CN, Goetzl EJ, Akers JC, Carter BS, Rockenstein EM, Galasko D, et al. Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile. Alzheimer’s Dement (Amsterdam, Netherlands). 2016;3:63–72.

Google Scholar 

Badhwar AP, Haqqani AS. Biomarker potential of brain-secreted extracellular vesicles in blood in Alzheimer’s disease. Alzheimer’s Dement Diagnosis, Assess Dis Monit. 2020;12(1):1–14.

Google Scholar 

Chan L, Chung CC, Chen JH, Yu RC, Hong CT. Cytokine profile in plasma extracellular vesicles of Parkinson’s disease and the association with cognitive function. Cells. 2021;10(3):1–9.

Article  Google Scholar 

Abner EL, Elahi FM, Jicha GA, Mustapic M, Al-Janabi O, Kramer JH, et al. Endothelial-derived plasma exosome proteins in Alzheimer’s disease angiopathy. FASEB J. 2020;34(4):5967–74.

Article  CAS  Google Scholar 

Brenna S, Altmeppen HC, Mohammadi B, Rissiek B, Schlink F, Ludewig P, et al. Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake. J Extracell Vesicles. 2020. https://doi.org/10.1080/20013078.2020.1809065.

Article  Google Scholar 

Drago F, Lombardi M, Prada I, Gabrielli M, Joshi P, Cojoc D, et al. ATP modifies the proteome of extracellular vesicles released by microglia and influences their action on astrocytes. Front Pharmacol. 2017;8:1–14.

Article  Google Scholar 

Osteikoetxea X, Sódar B, Németh A, Szabó-Taylor K, Pálóczi K, Vukman KV, et al. Differential detergent sensitivity of extracellular vesicle subpopulations. Org Biomol Chem. 2015;13(38):9775–82.

Article  CAS  Google Scholar 

Gomes J, Lucien F, Cooper TT, Kim Y, Williams KC, Liao X, et al. Analytical considerations in nanoscale flow cytometry of extracellular vesicles to achieve data linearity. Thromb Haemost. 2018;118(9):1612–24.

Article  Google Scholar 

Agalave NM, Lane BT, Mody PH, Szabo-Pardi TA, Burton MD. Isolation, culture, and downstream characterization of primary microglia and astrocytes from adult rodent brain and spinal cord. J Neurosci Methods. 2020;340(April):108742. https://doi.org/10.1016/j.jneumeth.2020.108742.

Article  CAS  Google Scholar 

Baxter PS, Dando O, Emelianova K, He X, McKay S, Hardingham GE, et al. Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes. Cell Rep. 2021;34(12):108882.

Article  CAS  Google Scholar 

Gibson CJ, Hossain MM, Richardson JR, Aleksunes LM. Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia. J Pharmacol Exp Ther. 2012;343(3):650–60.

Article  CAS  Google Scholar 

Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–8.

Article  CAS 

留言 (0)

沒有登入
gif