van Amsterdam J, Nutt D, Phillips L, van den Brink W (2015) European rating of drug harms. J Psychopharmacol 29:655–660. https://doi.org/10.1177/0269881115581980
(2020) Wide-ranging online data for epidemiologic research (WONDER). https://wonder.cdc.gov/. Accessed 7 Feb 2022
di Gaudio F, Mortali C, Tini A (2021) Opioid epidemic spread from Northern and Eastern Europe to Mediterranean Area. Clin Ter 172:209–210. https://doi.org/10.7417/CT.2021.2315
Stack E, Leichtling G, Larsen JE et al (2021) The impacts of COVID-19 on mental health, substance use, and overdose concerns of people who use drugs in rural communities. J Addict Med 15:383–389. https://doi.org/10.1097/ADM.0000000000000770
Müller UJ, Truebner K, Schiltz K et al (2015) Postmortem volumetric analysis of the nucleus accumbens in male heroin addicts: implications for deep brain stimulation. Eur Arch Psychiatry Clin Neurosci 265:647–653. https://doi.org/10.1007/s00406-015-0617-x
Müller UJ, Schiltz K, Mawrin C et al (2018) Total hypothalamic volume is reduced in postmortem brains of male heroin addicts. Eur Arch Psychiatry Clin Neurosci 268:243–248. https://doi.org/10.1007/s00406-017-0809-7
Müller UJ, Mawrin C, Frodl T et al (2019) Reduced volumes of the external and internal globus pallidus in male heroin addicts: a postmortem study. Eur Arch Psychiatry Clin Neurosci 269:317–324. https://doi.org/10.1007/s00406-018-0939-6
Müller UJ, Ahrens M, Vasilevska V et al (2021) Reduced habenular volumes and neuron numbers in male heroin addicts: a post-mortem study. Eur Arch Psychiatry Clin Neurosci 271:835–845. https://doi.org/10.1007/s00406-020-01195-y
Nieuwenhuys R (2012) The insular cortex. Progress in brain research. Elsevier, pp 123–163
Senatorov VV, Damadzic R, Mann CL et al (2015) Reduced anterior insula, enlarged amygdala in alcoholism and associated depleted von Economo neurons. Brain 138:69–79. https://doi.org/10.1093/brain/awu305
(Bud) Craig DA (2009) How do you feel—now? The anterior insula and human awareness. Nat Rev Neurosci 10:59–70. https://doi.org/10.1038/nrn2555
Naqvi NH, Rudrauf D, Damasio H, Bechara A (2007) Damage to the insula disrupts addiction to cigarette smoking. Science 315:531–534. https://doi.org/10.1126/science.1135926
Yousefzadeh-fard Y, Gharedaghi MH, Esmaeili S et al (2013) Stroke modifies drug consumption in opium addicts: role of the insula. Basic Clin Neurosci 4:29–36
Joshi DD, Puaud M, Fouyssac M et al (2020) The anterior insular cortex in the rat exerts an inhibitory influence over the loss of control of heroin intake and subsequent propensity to relapse. Eur J Neurosci 52:4115–4126. https://doi.org/10.1111/ejn.14889
Garavan H (2010) Insula and drug cravings. Brain Struct Funct 214:593–601. https://doi.org/10.1007/s00429-010-0259-8
Campbell EJ, Flanagan JPM, Walker LC et al (2019) Anterior insular cortex is critical for the propensity to relapse following punishment-imposed abstinence of alcohol seeking. J Neurosci 39:1077–1087. https://doi.org/10.1523/JNEUROSCI.1596-18.2018
Ibrahim C, Rubin-Kahana DS, Pushparaj A et al (2019) The insula: a brain stimulation target for the treatment of addiction. Front Pharmacol 10:720. https://doi.org/10.3389/fphar.2019.00720
Dinur-Klein L, Dannon P, Hadar A et al (2014) Smoking cessation induced by deep repetitive transcranial magnetic stimulation of the prefrontal and insular cortices: a prospective, randomized controlled trial. Biol Psychiatry 76:742–749. https://doi.org/10.1016/j.biopsych.2014.05.020
Chang H, Gao C, Sun K et al (2020) Continuous high frequency deep brain stimulation of the rat anterior insula attenuates the relapse post withdrawal and strengthens the extinction of morphine seeking. Front Psychiatry. https://doi.org/10.3389/fpsyt.2020.577155
Franklin TR, Acton PD, Maldjian JA et al (2002) Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients. Biol Psychiatry 51:134–142. https://doi.org/10.1016/s0006-3223(01)01269-0
Makris N, Gasic GP, Kennedy DN et al (2008) Cortical thickness abnormalities in cocaine addiction—a reflection of both drug use and a pre-existing disposition to drug abuse? Neuron 60:174–188. https://doi.org/10.1016/j.neuron.2008.08.011
Makris N, Oscar-Berman M, Jaffin SK et al (2008) Decreased volume of the brain reward system in alcoholism. Biol Psychiatry 64:192–202. https://doi.org/10.1016/j.biopsych.2008.01.018
Grodin EN, Cortes CR, Spagnolo PA, Momenan R (2017) Structural deficits in salience network regions are associated with increased impulsivity and compulsivity in alcohol dependence. Drug Alcohol Depend 179:100–108. https://doi.org/10.1016/j.drugalcdep.2017.06.014
Lyoo IK, Pollack MH, Silveri MM et al (2006) Prefrontal and temporal gray matter density decreases in opiate dependence. Psychopharmacology 184:139–144. https://doi.org/10.1007/s00213-005-0198-x
Yuan Y, Zhu Z, Shi J et al (2009) Gray matter density negatively correlates with duration of heroin use in young lifetime heroin-dependent individuals. Brain Cogn 71:223–228. https://doi.org/10.1016/j.bandc.2009.08.014
Isometsä ET (2001) Psychological autopsy studies—a review. Eur Psychiatry 16:379–385. https://doi.org/10.1016/s0924-9338(01)00594-6
Bernstein H-G, Stanarius A, Baumann B et al (1998) Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Neuroscience 83:867–875. https://doi.org/10.1016/S0306-4522(97)00461-2
Bernstein H-G, Baumann B, Danos P et al (1999) Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain. J Neurocytol 28:655–662. https://doi.org/10.1023/A:1007056731551
Gundersen HJ, Jensen EB (1987) The efficiency of systematic sampling in stereology and its prediction. J Microsc 147:229–263. https://doi.org/10.1111/j.1365-2818.1987.tb02837.x
Ding S, Royall JJ, Sunkin SM et al (2016) Comprehensive cellular-resolution atlas of the adult human brain. J Comp Neurol 524:3127–3481. https://doi.org/10.1002/cne.24080
Bielau H, Trübner K, Krell D et al (2005) Volume deficits of subcortical nuclei in mood disorders: a postmortem study. Eur Arch Psychiatry Clin Neurosci 255:401–412. https://doi.org/10.1007/s00406-005-0581-y
Baumann B, Danos P, Krell D et al (1999) Reduced volume of limbic system-affiliated basal ganglia in mood disorders: preliminary data from a postmortem study. J Neuropsychiatry Clin Neurosci 11:71–78. https://doi.org/10.1176/jnp.11.1.71
Katsel P, Byne W, Roussos P et al (2011) Astrocyte and glutamate markers in the superficial, deep, and white matter layers of the anterior cingulate gyrus in schizophrenia. Neuropsychopharmacology 36:1171–1177. https://doi.org/10.1038/npp.2010.252
Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B (Methodol) 57:289–300
Ghaziri J, Tucholka A, Girard G et al (2018) Subcortical structural connectivity of insular subregions. Sci Rep 8:8596. https://doi.org/10.1038/s41598-018-26995-0
Zhang R, Jia W, Wang Y et al (2019) A glutamatergic insular-striatal projection regulates the reinstatement of cue-associated morphine-seeking behavior in mice. Brain Res Bull 152:257–264. https://doi.org/10.1016/j.brainresbull.2019.07.023
Seif T, Chang S-J, Simms JA et al (2013) Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci 16:1094–1100. https://doi.org/10.1038/nn.3445
Menon V, Uddin LQ (2010) Saliency, switching, attention and control: a network model of insula function. Brain Struct Funct 214:655–667. https://doi.org/10.1007/s00429-010-0262-0
Sridharan D, Levitin DJ, Menon V (2008) A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. PNAS 105:12569–12574. https://doi.org/10.1073/pnas.0800005105
Droutman V, Read SJ, Bechara A (2015) Revisiting the role of the insula in addiction. Trends Cogn Sci 19:414–420. https://doi.org/10.1016/j.tics.2015.05.005
Upadhyay J, Maleki N, Potter J et al (2010) Alterations in brain structure and functional connectivity in prescription opioid-dependent patients. Brain 133:2098–2114. https://doi.org/10.1093/brain/awq138
Xie C, Shao Y, Fu L et al (2011) Identification of hyperactive intrinsic amygdala network connectivity associated with impulsivity in abstinent heroin addicts. Behav Brain Res 216:639–646. https://doi.org/10.1016/j.bbr.2010.09.004
Wollman SC, Alhassoon OM, Hall MG et al (2017) Gray matter abnormalities in opioid-dependent patients: a neuroimaging meta-analysis. Am J Drug Alcohol Abuse 43:505–517. https://doi.org/10.1080/00952990.2016.1245312
Wang L, Zou F, Zhai T et al (2016) Abnormal gray matter volume and resting-state functional connectivity in former heroin-dependent individuals abstinent for multiple years. Addict Biol 21:646–656. https://doi.org/10.1111/adb.12228
Gardini S, Venneri A (2012) Reduced grey matter in the posterior insula as a structural vulnerability or diathesis to addiction. Brain Res Bull 87:205–211. https://doi.org/10.1016/j.brainresbull.2011.11.021
Bernstein H-G, Trübner K, Krebs P et al (2014) Increased densities of nitric oxide synthase expressing neurons in the temporal cortex and the hypothalamic paraventricular nucleus of polytoxicomanic heroin overdose victims: possible implications for heroin neurotoxicity. Acta Histochem 116:182–190. https://doi.org/10.1016/j.acthis.2013.07.006
Cadet JL, Bisagno V, Milroy CM (2014) Neuropathology of substance use disorders. Acta Neuropathol 127:91–107.
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