Developmental Neuroscience

In Tribute to Verne S. Caviness, Jr.: Brief Report

Menassa D.A.a,b· Kopić J.b· Junaković A.b· Kostović I.b· Krsnik Ž.b

Author affiliations

aThe Queen’s College, University of Oxford, Oxford, UK
bCroatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia

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Article / Publication Details

First-Page Preview

Received: October 28, 2022
Accepted: December 19, 2022
Published online: January 05, 2023

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: https://www.karger.com/DNE

Abstract

Human neurodevelopment is characterized by the appearance, development, and disappearance or transformation of various transient structures that underlie the establishment of connectivity within and between future cortical and subcortical areas. Examples of transient structures in the forebrain (among many others) include the subpial granular layer and the subplate zone. We have previously characterized the precise spatiotemporal dynamics of microglia in the human telencephalon. Here, we describe the diversity of microglial morphologies in the subpial granular layer and the subplate zone. Where possible, we couple the predominant morphological phenotype with functional characterizations to infer tentative roles for microglia in a changing neurodevelopmental landscape. We interpret these findings within the context of relevant morphogenetic and neurogenetic events in humans. Due to the unique genetic, molecular, and anatomical features of the human brain and because many human neurological and psychiatric diseases have their origins during development, these structures deserve special attention.

© 2023 S. Karger AG, Basel

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First-Page Preview

Received: October 28, 2022
Accepted: December 19, 2022
Published online: January 05, 2023

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: https://www.karger.com/DNE

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