Baruch, K. et al. Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science 346, 89–93 (2014).
Mesquita, S. D. et al. The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer’s disease. Brain. Behav. Immun. 49, 280–292 (2015).
Stopa, E. G. et al. Comparative transcriptomics of choroid plexus in Alzheimer’s disease, frontotemporal dementia and Huntington’s disease: implications for CSF homeostasis. Fluids Barriers CNS 15, 18 (2018).
Van Hoecke, L. et al. Involvement of the choroid plexus in the pathogenesis of Niemann–Pick disease type C. Front. Cell. Neurosci. 15, 757482 (2021).
Liu, Y.-H. et al. One-year trajectory of cognitive changes in older survivors of COVID-19 in Wuhan, China: a longitudinal cohort study. JAMA Neurol. https://doi.org/10.1001/jamaneurol.2022.0461 (2022).
Hampshire, A. et al. Cognitive deficits in people who have recovered from COVID-19. EClinicalMedicine 39, 101044 (2021).
Deczkowska, A. et al. Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner. Nat. Commun. 8, 717 (2017).
Piras, M. et al. Strong ACE-2 expression in the choroidal vessels: do high choroid plexuses serve as a gateway for SARS-CoV-2 infection on the human brain? Eur. Rev. Med. Pharmacol. Sci. 26, 3025–3029 (2022).
Chen, R. et al. The spatial and cell-type distribution of SARS-CoV-2 receptor ACE2 in the human and mouse brains. Front. Neurol. 11, 573095 (2020).
Cosentino, G. et al. Neuropathological findings from COVID-19 patients with neurological symptoms argue against a direct brain invasion of SARS-CoV-2: a critical systematic review. Eur. J. Neurol. 28, 3856–3865 (2021).
Brady, M. et al. Spike protein multiorgan tropism suppressed by antibodies targeting SARS-CoV-2. Commun. Biol. 4, 1318 (2021).
Pellegrini, L. et al. SARS-CoV-2 infects the brain choroid plexus and disrupts the blood–CSF barrier in human brain organoids. Cell Stem Cell 27, 951–961 (2020).
Jacob, F. et al. Human pluripotent stem cell-derived neural cells and brain organoids reveal SARS-CoV-2 neurotropism predominates in choroid plexus epithelium. Cell Stem Cell 27, 937–950 (2020).
Deffner, F. et al. Histological evidence for the enteric nervous system and the choroid plexus as alternative routes of neuroinvasion by SARS-CoV-2. Front. Neuroanat. 14, 596439 (2020).
Yang, A. C. et al. Dysregulation of brain and choroid plexus cell types in severe COVID-19. Nature 595, 565–571 (2021).
Fullard, J. F. et al. Single-nucleus transcriptome analysis of human brain immune response in patients with severe COVID-19. Genome Med. 13, 118 (2021).
Jarius, S. et al. Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients. J. Neuroinflammation 19, 19 (2022).
Blank, T. et al. Brain endothelial- and epithelial-specific interferon receptor chain 1 drives virus-induced sickness behavior and cognitive impairment. Immunity 44, 901–912 (2016).
Fernández-Castañeda, A. et al. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell 185, 2452–2468 (2022).
Yin, C. et al. ApoE attenuates unresolvable inflammation by complex formation with activated C1q. Nat. Med. 25, 496–506 (2019).
Villeda, S. A. et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477, 90–94 (2011).
Baruch, K. et al. Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology. Nat. Commun. 6, 7967 (2015).
Cui, J. et al. Inflammation of the embryonic choroid plexus barrier following maternal immune activation. Dev. Cell 55, 617–628 (2020).
Cox, D. J. et al. DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease. Glia 63, 812–825 (2015).
Nazmi, A. et al. Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression. Glia 67, 1254–1276 (2019).
Filiano, A. J. et al. Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature 535, 425–429 (2016).
Deczkowska, A., Baruch, K. & Schwartz, M. Type I/II interferon balance in the regulation of brain physiology and pathology. Trends Immunol. 37, 181–192 (2016).
Yang, H.-S. et al. Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults. Alzheimers Dement. 18, 645–653 (2022).
Ruetsch, C. et al. Functional exhaustion of type I and II interferons production in severe COVID-19 patients. Front. Med. 7, 603961 (2021).
Diao, B. et al. Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19). Front. Immunol. 11, 827 (2020).
Pezeshki, P. S. & Rezaei, N. Immune checkpoint inhibition in COVID-19: risks and benefits. Expert Opin. Biol. Ther. 21, 1173–1179 (2021).
Galván-Peña, S. et al. Profound Treg perturbations correlate with COVID-19 severity. Proc. Natl Acad. Sci. USA 118, e2111315118 (2021).
Kasper, L. H. & Reder, A. T. Immunomodulatory activity of interferon-beta. Ann. Clin. Transl. Neurol. 1, 622–631 (2014).
Baruch, K. et al. PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer’s disease. Nat. Med. 22, 135–137 (2016).
Aschman, T., Mothes, R., Heppner, F. L. & Radbruch, H. What SARS-CoV-2 does to our brains. Immunity 55, 1159–1172 (2022).
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