Bers DM. Cardiac excitation-contraction coupling. Nature. 2002;415(6868):198–205.

CAS  Google Scholar 

Wu X, Chang B, Blair NS, Sargent M, York AJ, Robbins J, Shull GE, Molkentin JD. plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. J Clin Invest. 2009;119(4):976–85.

CAS  Google Scholar 

Belostotskaya GB, Golovanova TA. Characterization of contracting cardiomyocyte colonies in the primary culture of neonatal rat myocardial cells: a model of in vitro cardiomyogenesis. Cell Cycle. 2014;13(6):910–8.

CAS  Google Scholar 

Jiang K, Xu Y, Wang D, Chen F, Tu Z, Qian J, Xu S, Xu Y, Hwa J, Li J, Shang H, Xiang Y. Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis. Protein Cell. 2022;13(5):336–59.

CAS  Google Scholar 

Zhang H, Pei L, Ouyang Z, Wang H, Chen X, Jiang K, Huang S, Jiang R, Xiang Y, Wei K. AP-1 activation mediates postnatal cardiomyocyte maturation. Cardiovasc Res. 2022;cvac088. Advance online publication.

Navarrete EG, Liang P, Lan F, Sanchez-Freire V, Simmons C, Gong T, Sharma A, Burridge PW, Patlolla B, Lee AS, Wu H, Beygui RE, Wu SM, Robbins RC, Bers DM, Wu JC. Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation. 2013;128(11 Suppl 1):S3-13.

CAS  Google Scholar 

Karakikes I, Ameen M, Termglinchan V, Wu JC. Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes. Circ Res. 2015;117(1):80–8.

CAS  Google Scholar 

Kitani T, Ong SG, Lam CK, Rhee JW, Zhang JZ, Oikonomopoulos A, Ma N, Tian L, Lee J, Telli ML, Witteles RM, Sharma A, Sayed N, Wu JC. Human-induced pluripotent stem cell model of trastuzumab-induced cardiac dysfunction in patients with breast cancer. Circulation. 2019;139(21):2451–65.

CAS  Google Scholar 

Shinnawi R, Shaheen N, Huber I, Shiti A, Arbel G, Gepstein A, Ballan N, Setter N, Tijsen AJ, Borggrefe M, Gepstein L. Modeling reentry in the short QT syndrome with human-induced pluripotent stem cell-derived cardiac cell sheets. J Am Coll Cardiol. 2019;73(18):2310–24.

Google Scholar 

Lee J, Sutani A, Kaneko R, Takeuchi J, Sasano T, Kohda T, Ihara K, Takahashi K, Yamazoe M, Morio T, Furukawa T, Ishino F. In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix. Nat Commun. 2020;11(1):4283.

CAS  Google Scholar 

Hoang P, Kowalczewski A, Sun S, Winston TS, Archilla AM, Lemus SM, Ercan-Sencicek AG, Gupta AR, Liu W, Kontaridis MI, Amack JD, Ma Z. Engineering spatial-organized cardiac organoids for developmental toxicity testing. Stem Cell Reports. 2021;16(5):1228–44.

CAS  Google Scholar 

Goldfracht I, Efraim Y, Shinnawi R, Kovalev E, Huber I, Gepstein A, Arbel G, Shaheen N, Tiburcy M, Zimmermann WH, Machluf M, Gepstein L. Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications. Acta Biomater. 2019;92:145–59.

CAS  Google Scholar 

Eder A, Vollert I, Hansen A, Eschenhagen T. Human engineered heart tissue as a model system for drug testing. Adv Drug Deliv Rev. 2016;96:214–24.

CAS  Google Scholar 

Fowler ED, Wang N, Hezzell M, Chanoit G, Hancox JC, Cannell MB. Arrhythmogenic late Ca(2+) sparks in failing heart cells and their control by action potential configuration. Proc Natl Acad Sci U S A. 2020;117(5):2687–92.

CAS  Google Scholar 

Luongo TS, Lambert JP, Gross P, Nwokedi M, Lombardi AA, Shanmughapriya S, Carpenter AC, Kolmetzky D, Gao E, van Berlo JH, Tsai EJ, Molkentin JD, Chen X, Madesh M, Houser SR, Elrod JW. The mitochondrial Na(+)/Ca(2+) exchanger is essential for Ca(2+) homeostasis and viability. Nature. 2017;545(7652):93–7.

CAS  Google Scholar 

Kohlhaas M, Liu T, Knopp A, Zeller T, Ong MF, Bohm M, O’Rourke B, Maack C. Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes. Circulation. 2010;121(14):1606–13.

CAS  Google Scholar 

Duan X, Gao R, Xie P, Cohen-Karni T, Qing Q, Choe HS, Tian B, Jiang X, Lieber CM. Intracellular recordings of action potentials by an extracellular nanoscale field-effect transistor. Nat Nanotechnol. 2011;7(3):174–9.

Google Scholar 

van Meer BJ, Tertoolen LG, Mummery CL. Concise review: measuring physiological responses of human pluripotent stem cell derived cardiomyocytes to drugs and disease. Stem Cells. 2016;34(8):2008–15.

Google Scholar 

Scalzo S, Afonso MQL, da Fonseca NJ Jr, Jesus ICG, Alves AP, Mendonca C, Teixeira VP, Biagi D, Cruvinel E, Santos AK, Miranda K, Marques FAM, Mesquita ON, Kushmerick C, Campagnole-Santos MJ, Agero U, Guatimosim S. Dense optical flow software to quantify cellular contractility. Cell Rep Methods. 2021;1(4):100044.

CAS  Google Scholar 

Sala L, van Meer BJ, Tertoolen LGJ, Bakkers J, Bellin M, Davis RP, Denning C, Dieben MAE, Eschenhagen T, Giacomelli E, Grandela C, Hansen A, Holman ER, Jongbloed MRM, Kamel SM, Koopman CD, Lachaud Q, Mannhardt I, Mol MPH, Mosqueira D, Orlova VV, Passier R, Ribeiro MC, Saleem U, Smith GL, Burton FL, Mummery CL. MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo. Circ Res. 2018;122(3):e5–16.

CAS  Google Scholar 

Hayakawa T, Kunihiro T, Ando T, Kobayashi S, Matsui E, Yada H, Kanda Y, Kurokawa J, Furukawa T. Image-based evaluation of contraction-relaxation kinetics of human-induced pluripotent stem cell-derived cardiomyocytes: correlation and complementarity with extracellular electrophysiology. J Mol Cell Cardiol. 2014;77:178–91.

CAS  Google Scholar 

Steadman BW, Moore KB, Spitzer KW, Bridge JH. A video system for measuring motion in contracting heart cells. IEEE Trans Biomed Eng. 1988;35(4):264–72.

CAS  Google Scholar 

Ribeiro AJS, Schwab O, Mandegar MA, Ang YS, Conklin BR, Srivastava D, Pruitt BL. Multi-imaging method to assay the contractile mechanical output of micropatterned human iPSC-derived cardiac myocytes. Circ Res. 2017;120(10):1572–83.

CAS  Google Scholar 

Chen A, Lee E, Tu R, Santiago K, Grosberg A, Fowlkes C, Khine M. Integrated platform for functional monitoring of biomimetic heart sheets derived from human pluripotent stem cells. Biomaterials. 2014;35(2):675–83.

CAS  Google Scholar 

Horn BKP, Schunck BG. Determining optical flow. Artif Intell. 1981;17(1):185–203.

Google Scholar 

Deng R, Jiang K, Chen F, Miao Y, Lu Y, Su F, Liang J, Qian J, Wang D, Xiang Y, Shen L. Novel cardioprotective mechanism for empagliflozin in nondiabetic myocardial infarction with acute hyperglycemia. Biomed Pharmacother. 2022;154:113606.

CAS  Google Scholar 

Jiang K, Tu Z, Chen K, Xu Y, Chen F, Xu S, Shi T, Qian J, Shen L, Hwa J, Wang D, Xiang Y. Gasdermin D inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction. J Clin Invest. 2022;132(1):e151268.

Santos-Ribeiro A, Nutt DJ, McGonigle J. Inertial demons: a momentum-based diffeomorphic registration framework. In: Ourselin S, Joskowicz L, Sabuncu MR, Unal G, Wells W, editors. Medical Image Computing and Computer-Assisted Intervention - MICCAI 2016. Cham: Springer International Publishing; 2016. p. 37–45.

Google Scholar 

Hasenfuss G, Holubarsch C, Blanchard EM, Mulieri LA, Alpert NR, Just H. Influence of isoproterenol on myocardial energetics Experimental and clinical investigations. Basic Res Cardiol. 1989;84(Suppl 1):147–55.

Google Scholar 

Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klocker N, Trauner D. Optical control of L-type Ca(2+) channels using a diltiazem photoswitch. Nat Chem Biol. 2018;14(8):764–7.

CAS  Google Scholar 

Gallenberg LA, Stowe DF, Marijic J, Kampine JP, Bosnjak ZJ. Depression of atrial rate, atrioventricular nodal conduction, and cardiac contraction by diltiazem and volatile anesthetics in isolated hearts. Anesthesiology. 1991;74(3):519–30.

CAS  Google Scholar 

Helmy I, Scheinman MM, Herre JM, Sharkey H, Griffin JC. Electrophysiologic effects of isoproterenol in patients with atrioventricular reentrant tachycardia treated with flecainide. J Am Coll Cardiol. 1990;16(7):1649–55.

CAS  Google Scholar 

Butler L, Cros C, Oldman KL, Harmer AR, Pointon A, Pollard CE, Abi-Gerges N. Enhanced characterization of contractility in cardiomyocytes during early drug safety assessment. Toxicol Sci. 2015;145(2):396–406.

CAS  Google Scholar 

El-Ani D, Jacobson KA, Shainberg A. Characterization of adenosine receptors in intact cultured heart cells. Biochem Pharmacol. 1994;48(4):727–35.

CAS  Google Scholar 

Lam CK, Tian L, Belbachir N, Wnorowski A, Shrestha R, Ma N, Kitani T, Rhee JW, Wu JC. Identifying the transcriptome signatures of calcium channel blockers in human induced pluripotent stem cell-derived cardiomyocytes. Circ Res. 2019;125(2):212–22.

CAS  Google Scholar 

Sharma A, McKeithan WL, Serrano R, Kitani T, Burridge PW, Del Alamo JC, Mercola M, Wu JC. Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity. Nat Protoc. 2018;13(12):3018–41.

CAS  Google Scholar 

Campostrini G, Windt LM, van Meer BJ, Bellin M, Mummery CL. Cardiac tissues from stem cells: new routes to maturation and cardiac regeneration. Circ Res. 2021;128(6):775–801.

CAS  Google Scholar 

Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012;9(7):671–5.

CAS  Google Scholar 

Ruan JL, Tulloch NL, Razumova MV, Saiget M, Muskheli V, Pabon L, Reinecke H, Regnier M, Murry CE. Mechanical stress conditioning and electrical stimulation promote contractility and force maturation of induced pluripotent stem cell-derived human cardiac tissue. Circulation. 2016;134(20):1557–67.

CAS  Google Scholar 

Zhao Z, Wang W, Wang F, Zhao K, Han Y, Xu W, Tang L. Effects of astragaloside IV on heart failure in rats. Chin Med. 2009;4:6.

Google Scholar 

Lin X, Wang Q, Sun S, Xu G, Wu Q, Qi M, Bai F, Yu J. Astragaloside IV promotes the eNOS/NO/cGMP pathway and improves left ventricular diastolic function in rats with metabolic syndrome. J Int Med Res. 2020;48(1):300060519826848.

CAS  Google Scholar 

Zang Y, Wan J, Zhang Z, Huang S, Liu X, Zhang W. An updated role of astragaloside IV in heart failure. Biomed Pharmacother. 2020;126:110012.

CAS  Google Scholar 

Yu SY, Ouyang HT, Yang JY, Huang XL, Yang T, Duan JP, Cheng JP, Chen YX, Yang YJ, Qiong P. Subchronic toxicity studies of Radix Astragali extract in rats and dogs. J Ethnopharmacol. 2007;110(2):352–5.

Google Scholar