Adashek JJ, Desai AP, Andreev-Drakhlin AY, Roszik J, Cote GJ, Subbiah V (2021) Hallmarks of RET and Co-occuring genomic alterations in RET-aberrant cancers. Mol Cancer Ther 20(10):1769–1776

CAS  Google Scholar 

Airaksinen MS, Titievsky A, Saarma M (1999) GDNF family neurotrophic factor signaling: four masters, one servant? Mol Cell Neurosci 13(5):313–325

CAS  Google Scholar 

Bespalov MM, Sidorova YA, Tumova S, Ahonen-Bishopp A, Magalhaes AC, Kulesskiy E, Paveliev M, Rivera C, Rauvala H, Saarma M (2011) Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin. J Cell Biol 192(1):153–169

CAS  Google Scholar 

Besset V, Scott RP, Ibanez CF (2000) Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase. J Biol Chem 275(50):39159–39166

CAS  Google Scholar 

Boulay A, Breuleux M, Stephan C, Fux C, Brisken C, Fiche M, Wartmann M, Stumm M, Lane HA, Hynes NE (2008) The Ret receptor tyrosine kinase pathway functionally interacts with the ERalpha pathway in breast cancer. Cancer Res 68(10):3743–3751

CAS  Google Scholar 

Chatterjee O, Patil K, Sahu A, Gopalakrishnan L, Mol P, Advani J, Mukherjee S, Christopher R, Prasad TS (2016) An overview of the oxytocin-oxytocin receptor signaling network. J Cell Commun Signal 10(4):355–360

Google Scholar 

Chen M, Ba H, Lu C, Dai J, Sun J (2018) Glial cell line-derived neurotrophic factor (GDNF) promotes angiogenesis through the demethylation of the fibromodulin (FMOD) promoter in glioblastoma. Med Sci Monit 24:6137–6143

CAS  Google Scholar 

Cintron-Colon AF, Almeida-Alves G, Boynton AM, Spitsbergen JM (2020) GDNF synthesis, signaling, and retrograde transport in motor neurons. Cell Tissue Res 382(1):47–56

CAS  Google Scholar 

Costantini F, Shakya R (2006) GDNF/Ret signaling and the development of the kidney. BioEssays 28(2):117–127

CAS  Google Scholar 

Coulpier M, Ibanez CF (2004) Retrograde propagation of GDNF-mediated signals in sympathetic neurons. Mol Cell Neurosci 27(2):132–139

CAS  Google Scholar 

de Graaff E, Srinivas S, Kilkenny C, D’Agati V, Mankoo BS, Costantini F, Pachnis V (2001) Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. Genes Dev 15(18):2433–2444

Google Scholar 

Encinas M, Tansey MG, Tsui-Pierchala BA, Comella JX, Milbrandt J, Johnson EM Jr (2001) c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway. J Neurosci 21(5):1464–1472

CAS  Google Scholar 

Fisher CE, Michael L, Barnett MW, Davies JA (2001) Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney. Development 128(21):4329–4338

CAS  Google Scholar 

Gopalakrishnan L, Chatterjee O, Raj C, Pullimamidi D, Advani J, Mahadevan A, Keshava Prasad TS (2021) An assembly of galanin-galanin receptor signaling network. J Cell Commun Signal 15(2):269–275

CAS  Google Scholar 

Hayashi H, Ichihara M, Iwashita T, Murakami H, Shimono Y, Kawai K, Kurokawa K, Murakumo Y, Imai T, Funahashi H, Nakao A, Takahashi M (2000) Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor. Oncogene 19(39):4469–4475

CAS  Google Scholar 

He Z, Jiang J, Kokkinaki M, Golestaneh N, Hofmann MC, Dym M (2008) Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation. Stem Cells 26(1):266–278

CAS  Google Scholar 

Howland JG, Wang YT (2008) Synaptic plasticity in learning and memory: stress effects in the hippocampus. Prog Brain Res 169:145–158

CAS  Google Scholar 

Huber RM, Lucas JM, Gomez-Sarosi LA, Coleman I, Zhao S, Coleman R, Nelson PS (2015) DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance. Oncotarget 6(4):2134–2147

Google Scholar 

Irala D, Bonafina A, Fontanet PA, Alsina FC, Paratcha G, Ledda F (2016) The GDNF-GFRalpha1 complex promotes the development of hippocampal dendritic arbors and spines via NCAM. Development 143(22):4224–4235

CAS  Google Scholar 

Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A (2010) NetPath: a public resource of curated signal transduction pathways. Genome Biol 11(1):R3

Google Scholar 

Kawai K, Takahashi M (2020) Intracellular RET signaling pathways activated by GDNF. Cell Tissue Res 382(1):113–123

CAS  Google Scholar 

Kutmon M, van Iersel MP, Bohler A, Kelder T, Nunes N, Pico AR, Evelo CT (2015) PathVisio 3: an extendable pathway analysis toolbox. PLoS Comput Biol 11(2):e1004085

Article  CAS  Google Scholar 

Kutmon M, Riutta A, Nunes N, Hanspers K, Willighagen EL, Bohler A, Mélius J, Waagmeester A, Sinha SR, Miller R, Coort SL, Cirillo E, Smeets B, Evelo CT, Pico AR (2016) WikiPathways: capturing the full diversity of pathway knowledge. Nucleic Acids Res 44(D1):D488–D494

CAS  Google Scholar 

Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260(5111):1130–1132

CAS  Google Scholar 

Lin C, Cao W, Ren Z, Tang Y, Zhang C, Yang R, Chen Y, Liu Z, Peng C, Wang L, Wang X, Ji T (2017) GDNF secreted by nerves enhances PD-L1 expression via JAK2-STAT1 signaling activation in HNSCC. Oncoimmunology 6(11):e1353860

Google Scholar 

Lucini C, Maruccio L, Facello B, Cocchia N, Tortora G, Castaldo L (2008) Cellular localization of GDNF and its GFRalpha1/RET receptor complex in the developing pancreas of cat. J Anat 213(5):565–572

CAS  Google Scholar 

Mahato AK, Sidorova YA (2020) Glial cell line-derived neurotrophic factors (GFLs) and small molecules targeting RET receptor for the treatment of pain and Parkinson’s disease. Cell Tissue Res 382(1):147–160

CAS  Google Scholar 

Meng X, Lindahl M, Hyvonen ME, Parvinen M, de Rooij DG, Hess MW, Raatikainen-Ahokas A, Sainio K, Rauvala H, Lakso M, Pichel JG, Westphal H, Saarma M, Sariola H (2000) Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. Science 287(5457):1489–1493

CAS  Google Scholar 

Morandi A, Martin LA, Gao Q, Pancholi S, Mackay A, Robertson D, Zvelebil M, Dowsett M, Plaza-Menacho I, Isacke CM (2013) GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors. Cancer Res 73(12):3783–3795

CAS  Google Scholar 

Mulligan LM (2018) GDNF and the RET receptor in cancer: new insights and therapeutic potential. Front Physiol 9:1873

Google Scholar 

Paratcha G, Ledda F, Baars L, Coulpier M, Besset V, Anders J, Scott R, Ibanez CF (2001) Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts. Neuron 29(1):171–184

CAS  Google Scholar 

Plaza-Menacho I, Mologni L, McDonald NQ (2014) Mechanisms of RET signaling in cancer: current and future implications for targeted therapy. Cell Signal 26(8):1743–1752

CAS  Google Scholar 

Prescott JD, Zeiger MA (2015) The RET oncogene in papillary thyroid carcinoma. Cancer 121(13):2137–2146

CAS  Google Scholar 

Regua AT, Najjar M, Lo HW (2022) RET signaling pathway and RET inhibitors in human cancer. Front Oncol 12:932353

Google Scholar 

Ruan H, Luo H, Wang J, Ji X, Zhang Z, Wu J, Zhang X, Wu X (2016) Smoothened-independent activation of hedgehog signaling by rearranged during transfection promotes neuroblastoma cell proliferation and tumor growth. Biochim Biophys Acta 1860(9):1961–1972

CAS  Google Scholar 

Sahu A, Gopalakrishnan L, Gaur N, Chatterjee O, Mol P, Modi PK, Dagamajalu S, Advani J, Jain S, Keshava Prasad TS (2018) The 5-Hydroxytryptamine signaling map: an overview of serotonin-serotonin receptor mediated signaling network. J Cell Commun Signal 12(4):731–735

Google Scholar 

Sandhya VK, Raju R, Verma R, Advani J, Sharma R, Radhakrishnan A, Nanjappa V, Narayana J, Somani BL, Mukherjee KK, Pandey A, Christopher R, Prasad TS (2013) A network map of BDNF/TRKB and BDNF/p75NTR signaling system. J Cell Commun Signal 7(4):301–307

Google Scholar 

Santoro M, Carlomagno F (2013) Central role of RET in thyroid cancer. Cold Spring Harb Perspect Biol 5(12):a009233

Google Scholar 

Schuchardt A, D’Agati V, Pachnis V, Costantini F (1996) Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development. Development 122(6):1919–1929

CAS  Google Scholar 

Segouffin-Cariou C, Billaud M (2000) Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway. J Biol Chem 275(5):3568–3576

CAS  Google Scholar 

Subbannayya T, Balakrishnan L, Sudarshan G, Advani J, Kumar S, Mahmood R, Nair B, Sirdeshmukh R, Mukherjee KK, Umathe SN, Raju R, Prasad TS (2013) An integrated map of corticotropin-releasing hormone signaling pathway. J Cell Commun Signal 7(4):295–300

Google Scholar 

Subbiah V, Cote GJ (2020) Advances in targeting RET-dependent cancers. Cancer Discov 10(4):498–505

CAS  Google Scholar 

Takahashi M (2001) The GDNF/RET signaling pathway and human diseases. Cytokine Growth Factor Rev 12(4):361–373

CAS  Google Scholar 

Takahashi H, Funahashi H, Sawai H, Sakamoto M, Matsuo Y, Yamamoto M, Okada Y, Hayakawa T, Manabe T (2004) Glial cell line-derived neurotrophic factor enhances nuclear factor-kappaB activity and invasive potential in human pancreatic cancer cells. Pancreas 29(1):22–27

CAS  Google Scholar 

Thein KZ, Velcheti V, Mooers BHM, Wu J, Subbiah V (2021) Precision therapy for RET-altered cancers with RET inhibitors. Trends Cancer 7(12):1074–1088

CAS  Google Scholar 

Trupp M, Scott R, Whittemore SR, Ibanez CF (1999) Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells. J Biol Chem 274(30):20885–20894

CAS  Google Scholar 

Vastag B (2010) Biotechnology: crossing the barrier. Nature 466(7309):916–918

Google Scholar 

Veit C, Genze F, Menke A, Hoeffert S, Gress TM, Gierschik P, Giehl K (2004) Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells. Cancer Res 64(15):5291–5300

CAS  Google Scholar 

Wang M, Guo Y, Wang M, Zhou T, Xue Y, Du G, Wei X, Wang J, Qi L, Zhang H, Li L, Ye L, Guo X, Wu X (2017) The glial cell-derived neurotrophic factor (GDNF)-responsive phosphoprotein landscape identifies raptor phosphorylation required for spermatogonial progenitor cell proliferation. Mol Cell Proteomics 16(6):982–997

Google Scholar 

Yadav L, Pietila E, Ohman T, Liu X, Mahato AK, Sidorova Y, Lehti K, Saarma M, Varjosalo M (2020) PTPRA phosphatase regulates GDNF-dependent ret signaling and inhibits the RET mutant MEN2A oncogenic potential. Science 23(2):100871

CAS  Google Scholar 

Zihlmann KB, Ducray AD, Schaller B, Huber AW, Krebs SH, Andres RH, Seiler RW, Meyer M, Widmer HR (2005) The GDNF family members neurturin, artemin and persephin promote the morphological differentiation of cultured ventral mesencephalic dopaminergic neurons. Brain Res Bull 68(1–2):42–53

CAS  Google Scholar