Putative target sites in synganglion for novel ixodid tick control strategies

ElsevierVolume 14, Issue 3, May 2023, 102123Ticks and Tick-borne DiseasesAuthor links open overlay panelAbstract

Acaricide resistance is a global problem that has impacts worldwide. Tick populations with broad resistance to all commercially available acaricides have been reported. Since resistance selection in ticks and their role in pathogen transmission to animals and humans result in important economic and public health burden, it is essential to develop new strategies for their control (i.e., novel chemical compounds, vaccines, biological control). The synganglion is the tick central nervous system and it is responsible for synthesizing and releasing signaling molecules with different physiological functions. Synganglion proteins are the targets of the majority of available acaricides. In this review we provide an overview of the mode-of-action and resistance mechanisms against neurotoxic acaricides in ticks, as well as putative target sites in synganglion, as a supporting tool to identify new target proteins and to develop new strategies for tick control.

Keywords

Acaricide

Rhipicephalus microplus

Control

Data availability

No data was used for the research described in the article.

© 2023 The Author(s). Published by Elsevier GmbH.

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