Unresectable stage III non-small cell lung cancer: Insights from a Portuguese expert panel

Keywords

Stage III non-small cell lung cancer

Diagnosis

Staging

Treatment

Immunotherapy

Abbreviations18F-FDG

2-deoxy-2-(18F)fluoro-D-glucose

ALK

anaplastic lymphoma kinase

BRAF

B-raf proto-oncogene serine/threonine kinase

CCRT

concurrent chemoradiotherapy

COPD

chronic obstructive pulmonary disease

EBUS

endobronchial ultrasound

EGFR

epidermal growth factor receptor

EMA

European Medicines Agency

EMN

electromagnetic navigation

EUS

oesophageal ultrasound

FDA

Food and Drug Administration

FEV1

forced expiratory volume

FFPE

formalin-fixed paraffin-embedded

FNA

fine needle aspiration

HER2

human epidermal growth factor receptor 2

HER4

human epidermal growth factor receptor 4

IMRT

intensity-modulated radiotherapy

KRAS

kirsten rat sarcoma viral oncogene homologue

MDT

multidisciplinary team

MRI

magnetic resonance imaging

NGS

next-generation sequencing

NSCLC

non-small cell lung cancer

PD-1

programmed cell death protein-1

PD-L1

programmed cell death ligand-1

PET

positron emission tomography

PFS

Progression-free survival

PI3KCA

phosphatidylinositol 3-kinase catalytic subunit

ROS1

c-ros oncogene 1 receptor tyrosine kinase

SCRT

sequential chemoradiotherapy

SUVmax

maximum standardised uptake values

TBNA

transbronchial needle aspiration

TNM

T – Primary Tumour, N – Regional Lymph Nodes, M- Distant Metastasis

TPS

tumour proportion score

TTF1

thyroid transcription factor 1

TTNB

transthoracic needle biopsy

VAM

video-assisted mediastinoscopy

VATS

video-assisted thoracoscopic surgery

VMAT

volumetric modulated arc therapy

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