Neutrophil heterogeneity and emergence of a distinct population of CD11b/CD18-activated low-density neutrophils after trauma

From the Departments of Biological Engineering and Biology (I.G.R., B.A.J., T.R.E., M.B.Y.), Massachusetts Institute of Technology, Cambridge, Massachusetts; Koch Institute for Integrative Cancer Research (I.G.R., B.A.J., T.R.E., M.B.Y.), Massachusetts Institute of Technology, Cambridge, Massachusetts; Center for Precision Cancer Medicine (I.G.R., B.A.J., T.R.E., M.B.Y.), Massachusetts Institute of Technology, Cambridge, Massachusetts; Surgical Oncology Program (M.E.T., J.M.H., M.B.Y.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Department of Surgery (A.M.G., L.A.C., J.A.L.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Anesthesia, Critical Care, and Pain Medicine (V.M.B.-G., S.C.R.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; Department of Medicine (B.H.S.), Roswell Park Comprehensive Cancer Center, University of Buffalo School of Medicine, Buffalo, New York; and Department of Surgery (L.E.O., C.J.H., M.B.Y.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Submitted: July 30, 2022, Revised: September 28, 2022, Accepted: October 12, 2022, Published online: October 31, 2022.

I.G.R. and B.A.J. contributed equally to this study.

This study was presented at the 81st Annual Meeting of the American Association for the Surgery of Trauma, September 22, 2022, in Chicago, Illinois.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal’s Web site (www.jtrauma.com).

Address for correspondence: Michael B. Yaffe, MD, PhD, Koch Institute for Integrative Cancer Biology, Massachusetts Institute of Technology, 500 Main St, Bldg 76, Room 353, Cambridge, MA 02139. E-mail: [email protected].

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