Abu-Dief AM, Alsehli M, Awaad A (2022) A higher dose of PEGylated gold nanoparticles reduces the accelerated blood clearance phenomenon effect and induces spleen B lymphocytes in albino mice. Histochem Cell Biol 157(6):641–656. https://doi.org/10.1007/s00418-022-02086-0

Article  CAS  Google Scholar 

Almanaa TN, Aref M, Kakakhel MA, Elshopakey GE, Mahboub HH, Abdelazim AM, Kamel S, Belali TM, Abomughaid MM, Alhujaily M, Fahmy EM, Ezzat Assayed M, Mostafa-Hedeab G, Daoush WM (2022) Silica nanoparticle acute toxicity on male Rattus norvegicus domestica: ethological behavior, hematological disorders, biochemical analyses, hepato-renal function, and antioxidant-immune response. Front Bioeng Biotechnol. https://doi.org/10.3389/fbioe.2022.868111

Article  Google Scholar 

Awaad A (2020) The biodistribution of melanomacrophages and reactivity of PEG or amine-functionalized iron oxide nanoclusters in the liver and spleen of Egyptian toad after intraperitoneal or oral injections: Histochemical study. Acta Histochem. https://doi.org/10.1016/j.acthis.2020.151629

Article  Google Scholar 

Awaad A, Elkady EF, El-Mahdy SM (2022) Time-dependent biodistribution profiles and reaction of polyethylene glycol-coated iron oxide nanoclusters in the spleen after intravenous injection in the mice. Acta Histochem. https://doi.org/10.1016/j.acthis.2022.151907

Article  Google Scholar 

Casals E, Pfaller T, Duschl A, Oostingh GJ, Puntes V (2010) Time evolution of the nanoparticle protein corona. ACS Nano 4(7):3623–3632. https://doi.org/10.1021/nn901372t

Article  CAS  Google Scholar 

Croissant JG, Butler KS, Zink JI et al (2020) Synthetic amorphous silica nanoparticles: toxicity, biomedical and environmental implications. Nat Rev Mater 5:886–909

Article  CAS  Google Scholar 

Cruje C, Chithrani DB (2014) Polyethylene glycol density and length affects nanoparticle uptake by cancer cells. J Nanomed Res 1(1):00006. https://doi.org/10.15406/jnmr.2014.01.00006

Article  Google Scholar 

da Cruz Schneid A, Albuquerque LJC, Mondo GB et al (2022) Colloidal stability and degradability of silica nanoparticles in biological fluids: a review. J Sol-Gel Sci Technol. https://doi.org/10.1007/s10971-021-05695-8

Article  Google Scholar 

De Leo V, Milano F, Agostiano A, Catucci L (2021) Recent advancements in polymer/liposome assembly for drug delivery: from surface modifications to hybrid vesicles. Polymers (basel) 13(7):1027. https://doi.org/10.3390/polym13071027

Article  CAS  Google Scholar 

Heidegger S, Gössl D, Schmidt A, Niedermayer S, Argyo C, Endres S, Bein T, Bourquin C (2016) Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery. Nanoscale 8(2):938–948. https://doi.org/10.1039/c5nr06122a

Article  CAS  Google Scholar 

Ishida T, Kiwada H (2008) Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes. Int J Pharm 354(1–2):56–62. https://doi.org/10.1016/j.ijpharm.2007.11.005

Article  CAS  Google Scholar 

Kamarudin NH, Jalil AA, Triwahyono S, Salleh NF, Karim AH, Mukti RR, Hameed B, Ahmad A (2013) Role of 3-aminopropyltriethoxysilane in the preparation of mesoporous silica nanoparticles for ibuprofen delivery: Effect on physicochemical properties. Microporous Mesoporous Mater 180:235–241

Article  CAS  Google Scholar 

Karabasz A, Szczepanowicz K, Cierniak A, Mezyk-Kopec R, Dyduch G, Szczęch M, Bereta J, Bzowska M (2019) In vivo studies on pharmacokinetics, toxicity and immunogenicity of polyelectrolyte nanocapsules functionalized with two different polymers: Poly-L-Glutamic acid or PEG. Int J Nanomedicine 5(14):9587–9602. https://doi.org/10.2147/IJN.S230865

Article  Google Scholar 

Karim AH, Jalil AA, Triwahyono S, Sidik SM, Kamarudin NH, Jusoh R, Jusoh NW, Hameed BH (2012) Amino modified mesostructured silica nanoparticles for efficient adsorption of methylene blue. J Colloid Interface Sci 386(1):307–314

Article  CAS  Google Scholar 

Karmali PP, Simberg D (2011) Interactions of nanoparticles with plasma proteins: implication on clearance and toxicity of drug delivery systems. Expert Opin Drug Deliv 8(3):343–357. https://doi.org/10.1517/17425247.2011.554818

Article  CAS  Google Scholar 

Kumar, S., Bhushan, P., Bhattacharya, S. (2018). Positively Charged Silver Nanoparticles as Labels for Paper-Based Colorimetric Detection of Heparin. In: Ibrahim, F., Usman, J., Ahmad, M., Hamzah, N., Teh, S. (eds) 2nd International Conference for Innovation in Biomedical Engineering and Life Sciences. ICIBEL 2017. IFMBE Proceedings, vol 67. Springer, Singapore. https://doi.org/10.1007/978-981-10-7554-4_41

Larsen EK, Nielsen T, Wittenborn T, Rydtoft LM, Lokanathan AR, Hansen L, Østergaard L, Kingshott P, Howard KA, Besenbacher F, Nielsen NC, Kjems J (2012) Accumulation of magnetic iron oxide nanoparticles coated with variably sized polyethylene glycol in murine tumors. Nanoscale 4(7):2352–2361. https://doi.org/10.1039/c2nr11554a

Article  CAS  Google Scholar 

Lee JE, Lee N, Kim T, Kim J, Hyeon T (2011) Multifunctional mesoporous silica nanocomposite nanoparticles for theranostic applications. Acc Chem Res 44(10):893–902. https://doi.org/10.1021/ar2000259

Article  CAS  Google Scholar 

Lee S, Kim MS, Lee D, Kwon TK, Khang D, Yun HS, Kim SH (2013) The comparative immunotoxicity of mesoporous silica nanoparticles and colloidal silica nanoparticles in mice. Int J Nanomedicine 8:147–158. https://doi.org/10.2147/IJN.S39534. (Epub 2013 Jan 7)

Article  CAS  Google Scholar 

Li SD, Huang L (2010) Stealth nanoparticles: high density but sheddable PEG is a key for tumor targeting. J Control Release 145(3):178–181. https://doi.org/10.1016/j.jconrel.2010.03.016

Article  CAS  Google Scholar 

Li C, Zhao X, Wang Y, Yang H, Li H, Li H, Tian W, Yang J, Cui J (2013) Prolongation of time interval between doses could eliminate accelerated blood clearance phenomenon induced by pegylated liposomal topotecan. Int J Pharm 443(1–2):17–25. https://doi.org/10.1016/j.ijpharm.2013.01.012

Article  CAS  Google Scholar 

Li T, Shi S, Goel S, Shen X, Xie X, Chen Z, Zhang H, Li S, Qin X, Yang H, Wu C, Liu Y (2019) Recent advancements in mesoporous silica nanoparticles towards therapeutic applications for cancer. Acta Biomater 15(89):1–13. https://doi.org/10.1016/j.actbio.2019.02.031

Article  CAS  Google Scholar 

Lin IC, Liang M, Liu TY et al (2012) Effect of polymer grafting density on silica nanoparticle toxicity. Bioorg Med Chem 20(23):6862–6869. https://doi.org/10.1016/j.bmc.2012.09.045

Article  CAS  Google Scholar 

Liu Y, Hu Y, Huang L (2014) Influence of polyethylene glycol density and surface lipid on pharmacokinetics and biodistribution of lipid-calcium-phosphate nanoparticles. Biomaterials 35(9):3027–3034. https://doi.org/10.1016/j.biomaterials.2013.12.022

Article  CAS  Google Scholar 

Lundqvist M, Sethson I, Jonsson BH (2004) Protein adsorption onto silica nanoparticles: conformational changes depend on the particles’ curvature and the protein stability. Langmuir 20(24):10639–10647. https://doi.org/10.1021/la0484725. (PMID: 15544396)

Article  CAS  Google Scholar 

Luo Z, Hu Y, Xin R, Zhang B, Li J, Ding X, Hou Y, Yang L, Cai K (2014) Surface functionalized mesoporous silica nanoparticles with natural proteins for reduced immunotoxicity. J Biomed Mater Res A 102(11):3781–3794. https://doi.org/10.1002/jbm.a.35049

Article  CAS  Google Scholar 

Machado Cruz R, Santos-Martinez MJ, Tajber L (2019) Impact of polyethylene glycol polymers on the physicochemical properties and mucoadhesivity of itraconazole nanoparticles. Eur J Pharm Biopharm 144:57–67. https://doi.org/10.1016/j.ejpb.2019.09.004

Article  CAS  Google Scholar 

Manson J, Kumar D, Meenan BJ et al (2011) Polyethylene glycol functionalized gold nanoparticles: the influence of capping density on stability in various media. Gold Bull 44:99–105. https://doi.org/10.1007/s13404-011-0015-8

Article  CAS  Google Scholar 

Mima Y, Hashimoto Y, Shimizu T, Kiwada H, Ishida T (2015) Anti-PEG IgM is a major contributor to the accelerated blood clearance of polyethylene glycol-conjugated protein. Mol Pharm 12(7):2429–2435. https://doi.org/10.1021/acs.molpharmaceut.5b00144

Article  CAS  Google Scholar 

Mukti RR, Hirahara H, Sugawara A, Shimojima A, Okubo T (2010) Direct hydrothermal synthesis of hierarchically porous siliceous zeolite by using alkoxysilylated nonionic surfactant. Langmuir 26(4):2731–2735

Article  CAS  Google Scholar 

Papini E, Tavano R, Mancin F (2020) Opsonins and dysopsonins of nanoparticles: facts, concepts, and methodological guidelines. Front Immunol. https://doi.org/10.3389/fimmu.2020.567365

Article  Google Scholar 

Perry JL, Reuter KG, Kai MP, Herlihy KP, Jones SW, Luft JC, Napier M, Bear JE, DeSimone JM (2012) PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics. Nano Lett 12(10):5304–5310. https://doi.org/10.1021/nl302638g

Article  CAS  Google Scholar 

Santra S (2010) Fluorescent silica nanoparticles for cancer imaging. Methods Mol Biol 624:151–162. https://doi.org/10.1007/978-1-60761-609-2_10

Article  CAS  Google Scholar 

Simon J, Wolf T, Klein K, Landfester K, Wurm FR, Mailänder V (2018) Hydrophilicity regulates the stealth properties of polyphosphoester-coated nanocarriers. Angew Chem Int Ed Engl 57(19):5548–5553. https://doi.org/10.1002/anie.201800272

Article  CAS  Google Scholar 

Souris JS, Lee CH, Cheng SH, Chen CT, Yang CS, Ho JA, Mou CY, Lo LW (2010) Surface charge-mediated rapid hepatobiliary excretion of mesoporous silica nanoparticles. Biomaterials 31(21):5564–5574. https://doi.org/10.1016/j.biomaterials.2010.03.048

Article  CAS  Google Scholar 

Sriwidodo UAK, Wathoni N, Zothantluanga JH, Das S, Luckanagul JA (2022) Liposome-polymer complex for drug delivery system and vaccine stabilization. Heliyon. https://doi.org/10.1016/j.heliyon.2022.e08934

Article  Google Scholar 

Sunoqrot S, Bugno J, Lantvit D, Burdette JE, Hong S (2014) Prolonged blood circulation and enhanced tumor accumulation of folate-targeted dendrimer-polymer hybrid nanoparticles. J Control Release 10(191):115–122. https://doi.org/10.1016/j.jconrel.2014.05.006

Article  CAS  Google Scholar 

Tallury P, Payton K, Santra S (2008) Silica-based multimodal/multifunctional nanoparticles for bioimaging and biosensing applications. Nanomedicine (lond) 3(4):579–592. https://doi.org/10.2217/17435889.3.4.579

Article  CAS  Google Scholar 

Uz M, Bulmus V, Alsoy AS (2016) Effect of PEG grafting density and hydrodynamic volume on gold nanoparticle-cell interactions: an investigation on cell cycle, apoptosis, and DNA damage. Langmuir 32(23):5997–6009. https://doi.org/10.1021/acs.langmuir.6b01289

Article  CAS  Google Scholar 

Wang X, Ishida T, Kiwada H (2007) Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes. J Control Release 119(2):236–244. https://doi.org/10.1016/j.jconrel.2007.02.010

Article  CAS  Google Scholar 

Wang Y, Zhao Q, Han N, Bai L, Li J, Liu J, Che E, Hu L, Zhang Q, Jiang T, Wang S (2015) Mesoporous silica nanoparticles in drug delivery and biomedical applications. Nanomedicine 11(2):313–327. https://doi.org/10.1016/j.nano.2014.09.014

Article  CAS