Wefel JS, Kesler SR, Noll KR, Schagen SB. Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer-related cognitive impairment in adults. CA Cancer J Clin. 2015;65(2):123–38.

Article  Google Scholar 

Janelsins MC, Kesler SR, Ahles TA, Morrow GR. Prevalence, mechanisms, and management of cancer-related cognitive impairment. Int Rev Psychiatry. 2014;26(1):102–13.

Article  Google Scholar 

Mayo SJ, Lustberg M, M Dhillon H, Nakamura ZM, Allen DH, Von Ah D, et al. Cancer-related cognitive impairment in patients with non-central nervous system malignancies: an overview for oncology providers from the MASCC neurological complications study group. Support Care Cancer. 2021;29(6):2821–40.

Article  Google Scholar 

Ahles TA, Saykin AJ, McDonald BC, Li Y, Furstenberg CT, Hanscom BS, et al. Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve. J Clin Oncol. 2010;28(29):4434–40.

Article  Google Scholar 

Koppelmans V, van der Willik KD, Aleman BMP, van Leeuwen FE, Kavousi M, Arshi B, et al. Long-term effects of adjuvant treatment for breast cancer on carotid plaques and brain perfusion. Breast Cancer Res Treat. 2021;186(1):167–76.

Article  Google Scholar 

Henneghan A, Haley AP, Kesler S. Exploring relationships among peripheral amyloid Beta, tau, cytokines, cognitive function, and psychosomatic symptoms in breast Cancer survivors. Biol Res Nurs. 2020;22(1):126–38.

Article  CAS  Google Scholar 

Sanoff HK, Deal AM, Krishnamurthy J, Torrice C, Dillon P, Sorrentino J, et al. Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer. J Natl Cancer Inst. 2014;106(4):dju057.

Article  Google Scholar 

Carroll JE, Van Dyk K, Bower JE, Scuric Z, Petersen L, Schiestl R, et al. Cognitive performance in survivors of breast cancer and markers of biological aging. Cancer. 2019;125(2):298–306.

Article  CAS  Google Scholar 

Scuric Z, Carroll JE, Bower JE, Ramos-Perlberg S, Petersen L, Esquivel S, et al. Biomarkers of aging associated with past treatments in breast cancer survivors. NPJ Breast Cancer. 2017;3:50.

Article  Google Scholar 

Hirokawa N, Shiomura Y, Okabe S. Tau proteins: the molecular structure and mode of binding on microtubules. J Cell Biol. 1988;107(4):1449–59.

Article  CAS  Google Scholar 

Kent SA, Spires-Jones TL, Durrant CS. The physiological roles of tau and Abeta: implications for Alzheimer's disease pathology and therapeutics. Acta Neuropathol. 2020;140(4):417–47.

Article  CAS  Google Scholar 

Rodriguez GA, Barrett GM, Duff KE, Hussaini SA. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Abeta and tau pathology in the hippocampus. PLoS Biol. 2020;18(8):e3000851.

Article  CAS  Google Scholar 

Castellani RJ, Perry G. Tau biology, Tauopathy, traumatic brain injury, and diagnostic challenges. J Alzheimers Dis. 2019;67(2):447–67.

Article  CAS  Google Scholar 

Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol. 2014;128(6):755–66.

Article  CAS  Google Scholar 

Tseng JH, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The deacetylase HDAC6 mediates endogenous Neuritic tau pathology. Cell Rep. 2017;20(9):2169–83.

Article  CAS  Google Scholar 

McCann H, Durand B, Shepherd CE. Aging-related tau Astrogliopathy in aging and neurodegeneration. Brain Sci. 2021;11(7):927.

Article  CAS  Google Scholar 

Chiang ACA, Huo X, Kavelaars A, Heijnen CJ. Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment. Brain Behav Immun. 2019;79:319–25. https://doi.org/10.1016/j.bbi.2019.04.005.

Article  CAS  Google Scholar 

Ma J, Huo X, Jarpe MB, Kavelaars A, Heijnen CJ. Pharmacological inhibition of HDAC6 reverses cognitive impairment and tau pathology as a result of cisplatin treatment. Acta Neuropathol Commun. 2018;6(1):103.

Article  Google Scholar 

Levy O, Kuai R, Siren EMJ, Bhere D, Milton Y, Nissar N, et al. Shattering barriers toward clinically meaningful MSC therapies. Sci Adv. 2020;6(30):eaba6884.

Article  CAS  Google Scholar 

Baak LM, Wagenaar N, van der Aa NE, Groenendaal F, Dudink J, Tataranno ML, et al. Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN): a first-in-human, open-label intervention study. The Lancet Neurol. 2022;21(6):528–36.

Article  Google Scholar 

van Velthoven CT, van de Looij Y, Kavelaars A, Zijlstra J, van Bel F, Huppi PS, et al. Mesenchymal stem cells restore cortical rewiring after neonatal ischemia in mice. Ann Neurol. 2012;71(6):785–96.

Article  Google Scholar 

Donega V, Nijboer CH, van Velthoven CT, Youssef SA, de Bruin A, van Bel F, et al. Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse. Pediatr Res. 2015;78(5):520.

Article  CAS  Google Scholar 

Donega V, van Velthoven CT, Nijboer CH, Kavelaars A, Heijnen CJ. The endogenous regenerative capacity of the damaged newborn brain: boosting neurogenesis with mesenchymal stem cell treatment. J Cereb Blood Flow Metab. 2013;33(5):625–34.

Article  Google Scholar 

Qin C, Lu Y, Wang K, Bai L, Shi G, Huang Y, et al. Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer's disease: a meta-analytic review on potential mechanisms. Transl Neurodegener. 2020;9(1):20.

Article  Google Scholar 

Nair S, Rocha-Ferreira E, Fleiss B, Nijboer CH, Gressens P, Mallard C, et al. Neuroprotection offered by mesenchymal stem cells in perinatal brain injury: role of mitochondria, inflammation, and reactive oxygen species. J Neurochem. 2021;158(1):59–73.

Article  CAS  Google Scholar 

Yu-Taeger L, Stricker-Shaver J, Arnold K, Bambynek-Dziuk P, Novati A, Singer E, et al. Intranasal Administration of Mesenchymal Stem Cells Ameliorates the abnormal dopamine transmission system and inflammatory reaction in the R6/2 mouse model of Huntington disease. Cells. 2019;8(6):595.

Article  CAS  Google Scholar 

Chiu GS, Chiang ACA, Peng B, Rao V, Kingsley C, Liu H-L, et al. Nasal administration of mesenchymal stem cells restores cisplatin-induced cognitive impairment and brain damage in mice. submitted. Oncotarget. 2018;9(85):35581–97. https://doi.org/10.18632/oncotarget.26272.

Article  Google Scholar 

Boukelmoune N, Chiu GS, Kavelaars A, Heijnen CJ. Mitochondrial transfer from mesenchymal stem cells to neural stem cells protects against the neurotoxic effects of cisplatin. Acta Neuropathol Commun. 2018;6(1):139.

Article  CAS  Google Scholar 

Hudak A, Kusz E, Domonkos I, Josvay K, Kodamullil AT, Szilak L, et al. Contribution of syndecans to cellular uptake and fibrillation of alpha-synuclein and tau. Sci Rep. 2019;9(1):16543.

Article  Google Scholar 

Van Acker ZP, Perdok A, Bretou M, Annaert W. The microglial lysosomal system in Alzheimer's disease: Guardian against proteinopathy. Ageing Res Rev. 2021;71:101444.

Article  Google Scholar 

Takata K, Ginhoux F, Shimohama S. Roles of microglia in Alzheimer's disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention. Biochem Pharmacol. 2021;192:114754.

Article  CAS  Google Scholar 

Wu J, Carlock C, Shim J, Moreno-Gonzalez I, Glass W 2nd, Ross A, et al. Requirement of brain interleukin33 for aquaporin4 expression in astrocytes and glymphatic drainage of abnormal tau. Mol Psychiatry. 2021;26(10):5912.

Article  CAS  Google Scholar 

Chiu GS, Maj MA, Rizvi S, Dantzer R, Vichaya EG, Laumet G, et al. Pifithrin-mu prevents cisplatin-induced Chemobrain by preserving neuronal mitochondrial function. Cancer Res. 2017;77(3):742–52.

Article  CAS  Google Scholar 

Chiang ACA, Seua AV, Singhmar P, Arroyo LD, Mahalingam R, Hu J, et al. Bexarotene normalizes chemotherapy-induced myelin decompaction and reverses cognitive and sensorimotor deficits in mice. Acta Neuropathol Commun. 2020;8(1):193.

Article  CAS  Google Scholar 

Guida JL, Ahles TA, Belsky D, Campisi J, Cohen HJ, DeGregori J, et al. Measuring aging and identifying aging phenotypes in Cancer survivors. J Natl Cancer Inst. 2019;111(12):1245–54.

Article  CAS  Google Scholar 

Dias-Carvalho A, Ferreira M, Ferreira R, Bastos ML, Sa SI, Capela JP, et al. Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events. Arch Toxicol. 2021;96(1):11–78.

Article  Google Scholar 

Driver JA, Beiser A, Au R, Kreger BE, Splansky GL, Kurth T, et al. Inverse association between cancer and Alzheimer's disease: results from the Framingham heart study. BMJ. 2012;344:e1442.

Article  Google Scholar 

Musicco M, Adorni F, Di Santo S, Prinelli F, Pettenati C, Caltagirone C, et al. Inverse occurrence of cancer and Alzheimer disease: a population-based incidence study. Neurology. 2013;81(4):322–8.

Article  Google Scholar 

Roe CM, Behrens MI, Xiong C, Miller JP, Morris JC. Alzheimer disease and cancer. Neurology. 2005;64(5):895–8.

Article  CAS  Google Scholar 

Du XL, Cai Y, Symanski E. Association between chemotherapy and cognitive impairments in a large cohort of patients with colorectal cancer. Int J Oncol. 2013;42(6):2123–33.

Article  Google Scholar 

Heck JE, Albert SM, Franco R, Gorin SS. Patterns of dementia diagnosis in surveillance, epidemiology, and end results breast cancer survivors who use chemotherapy. J Am Geriatr Soc. 2008;56(9):1687–92.

Article  Google Scholar 

Maass A, Lockhart SN, Harrison TM, Bell RK, Mellinger T, Swinnerton K, et al. Entorhinal tau pathology, episodic memory decline, and neurodegeneration in aging. J Neurosci. 2018;38(3):530–43.

Article  CAS  Google Scholar 

Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, et al. The impact of amyloid-beta and tau on prospective cognitive decline in older individuals. Ann Neurol. 2019;85(2):181–93.

CAS  Google Scholar 

Saha P, Sen N. Tauopathy: a common mechanism for neurodegeneration and brain aging. Mech Ageing Dev. 2019;178:72–9.

Article  CAS