A pipeline for identification and validation of brain targets for weight loss

Schneeberger, M. et al. Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction. Nat. Metab. 4, 1495–1513 (2022).

Article  CAS  Google Scholar 

Nectow, A. R. et al. Identification of a brainstem circuit controlling feeding. Cell 170, 429–442 (2017).

Article  CAS  Google Scholar 

Ren, J. et al. Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei. eLife 8, e49424 (2019).

Article  CAS  Google Scholar 

Xiao, X. et al. Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nat. Commun. 12, 5249 (2021).

Article  CAS  Google Scholar 

Han, Y. et al. Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding. Nat. Commun. 12, 3525 (2021).

Article  CAS  Google Scholar 

Abbas, M. G. et al. Comprehensive behavioral analysis of male Ox1r−/− mice showed implication of orexin receptor-1 in mood, anxiety, and social behavior. Front. Behav. Neurosci. 9, 324 (2015).

Article  Google Scholar 

Jennings, J. H., Rizzi, G., Stamatakis, A. M., Ung, R. L. & Stuber, G. D. The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding. Science 341, 1517–1521 (2013).

Article  CAS  Google Scholar 

He, Y. et al. 5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding. Mol. Psychiatry 26, 7211–7224 (2021).

Article  CAS  Google Scholar 

Mickelsen, L. E. et al. Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons. Nat. Neurosci. 22, 642–656 (2019).

Article  CAS  Google Scholar 

Pollak Dorocic, I. et al. A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei. Neuron 83, 663–678 (2014).

Article  CAS  Google Scholar 

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