High accuracy of a simplified, practical algorithm in differentiating Crohn's Disease from Intestinal Tuberculosis

Small and Large Bowel: Research Article

Hilmi I.N. · Nik Muhammad Affendi N.A. · Shahrani S. · Thalha A.M. · Leow H.-R. · Khoo X.-H.

Log in to MyKarger to check if you already have access to this content.

Buy FullText & PDF Unlimited re-access via MyKarger Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.

Save over 20% compared to the individual article price.

Learn more

Rent via DeepDyve Unlimited fulltext viewing of this article Organize, annotate and mark up articles Printing and downloading restrictions apply

Start free trial

Subscribe Access to all articles of the subscribed year(s) guaranteed for 5 years Unlimited re-access via Subscriber Login or MyKarger Unrestricted printing, no saving restrictions for personal use read more

Subcription rates

Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details Abstract

Background: The differentiation between intestinal tuberculosis from Crohn's disease remains a challenge, particularly in areas where tuberculosis is highly prevalent. Previous studies have identified features that favor one diagnosis over the other. To determine the accuracy of a standardized protocol in the initial diagnosis of Crohn’s disease versus intestinal tuberculosis. Methods: All patients with suspected intestinal tuberculosis or Crohn’s disease were prospectively recruited. A standardized protocol was applied and the diagnosis was made accordingly. The protocol consists of; history and examination, ileocolonoscopy with biopsies, and tuberculosis workup. The diagnosis of probable intestinal tuberculosis was made based on at least one positive finding. All other patients were diagnosed as probable Crohn’s disease. Patients were treated either with anti-tubercular therapy or steroids. Reassessment was then carried out clinically, biochemically and endoscopically. In patients with suboptimal response, the treatment was either switched or escalated depending on the reassessment. Results: 164 patients were recruited with final diagnosis of 30 (18.3%) intestinal tuberculosis and 134 (81.7%) Crohn’s disease. 1 (3.3%) out of 30 patients with intestinal tuberculosis was initially treated as Crohn’s disease. 16 (11.9%) out of 134 patients with Crohn’s disease were initially treated as intestinal tuberculosis. The initial overall accuracy for the protocol was 147/164 (89.6%). All patients received the correct diagnosis by 12 weeks after reassessment. Conclusion: In our population, most patients had CD rather than ITB. The standardized protocol had a high accuracy in differentiating CD from ITB.

S. Karger AG, Basel

Article / Publication Details Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

留言 (0)

沒有登入
gif