Mapping Cryptic Binding Sites of Drug Targets to Overcome Drug Resistance

Elsevier

Available online 23 January 2023, 100934

Drug Resistance UpdatesAuthor links open overlay panelABSTRACT

The emergence of drug resistance is a primary obstacle for successful chemotherapy. Drugs that target cryptic binding sites (CBSs) represent a novel strategy for overcoming drug resistance. In this short communication, we explain and discuss how the discovery of CBSs and their inhibitors can overcome drug resistance.

Keywords

Drug resistance

Cryptic binding sites

Resistance management

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