Alvarez-Alvarez I, Niu H, Guillen-Grima F, Aguinaga-Ontoso I. Meta-analysis of prevalence of wheezing and recurrent wheezing in infants. Allergol Immunopathol. 2018;46(3):210–7.

Article  CAS  Google Scholar 

Owora AH, Zhang Y. Childhood wheeze trajectory-specific risk factors: a systematic review and meta-analysis. Pediatr Allergy Immunol. 2021;32(1):34–50.

Article  Google Scholar 

Vandini S, Biagi C, Fischer M, Lanari M. Impact of rhinovirus infections in children. Viruses. 2019;11(6):521.

Article  CAS  Google Scholar 

Al-Kassimi FA, Alhamad EH, Al-Hajjaj MS, Raddaoui E, Alzeer AH, Alboukai AA, et al. Can computed tomography and carbon monoxide transfer coefficient diagnose an asthma-like phenotype in COPD? Respirology (Carlton, VIC). 2017;22(2):322–8.

Article  Google Scholar 

Qi YY, Jiang GL, Wang LB, Wan CZ, Zhang XB, Qian LL. Lung function in wheezing infants after acute lower respiratory tract infection and its association with respiratory outcome. Chin Med J. 2017;130(1):4–10.

Article  Google Scholar 

Zhang Y, Jing Y, Qiao J, Luan B, Wang X, Wang L, et al. Activation of the mTOR signaling pathway is required for asthma onset. Sci Rep. 2017;7(1):4532.

Article  Google Scholar 

Yu C, Zhuang S. Histone methyltransferases as therapeutic targets for kidney diseases. Front Pharmacol. 2019;10:1393.

Article  CAS  Google Scholar 

Kim J, Lee Y, Lu X, Song B, Fong KW, Cao Q, et al. Polycomb- and methylation-independent roles of EZH2 as a transcription activator. Cell Rep. 2018;25(10):2808-20.e4.

Article  CAS  Google Scholar 

Duan R, Du W, Guo W. EZH2: a novel target for cancer treatment. J Hematol Oncol. 2020;13(1):104.

Article  Google Scholar 

Ntontsi P, Photiades A, Zervas E, Xanthou G, Samitas K. Genetics and epigenetics in asthma. Int J Mol Sci. 2021;22(5):2412.

Article  CAS  Google Scholar 

Li Y, Li H, Zhou L. EZH2-mediated H3K27me3 inhibits ACE2 expression. Biochem Biophys Res Commun. 2020;526(4):947–52.

Article  CAS  Google Scholar 

Hu Z, Chen Y, He J, Liu H, Hui T. EZH2 might affect macrophage chemotaxis and anti-inflammatory factors by regulating CCL2 in dental pulp inflammation. Stem Cells Int. 2021;2021:3060480.

Article  Google Scholar 

Zhang L, Wan Y, Ma L, Xu K, Cheng B. Inhibition of NF-κB/IL-33/ST2 axis ameliorates acute bronchiolitis induced by respiratory syncytial virus. J Immunol Res. 2021;2021:6625551.

Article  Google Scholar 

Moral-Hernández OD, Santiago-Olivares C, Rivera-Toledo E, Gaona J, Castillo-Villanueva E, Gómez B. RSV infection in a macrophage-cell line activates the non-canonical NF-κB pathway and induces pro-inflammatory cytokine expression. Acta Virol. 2018;62(2):129–36.

Article  Google Scholar 

Devi K, Soni S, Tripathi V, Pandey R, Moharana B. Ethanolic extract of tridax procumbens mitigates pulmonary inflammation via inhibition of NF-κB/p65/ERK mediated signalling in an allergic asthma model. Phytomed Int J Phytother Phytopharmacol. 2022;99:154008.

CAS  Google Scholar 

Lee JY, Mehrazarin S, Alshaikh A, Kim S, Chen W, Lux R, et al. Histone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-κB signaling and osteoclastogenesis. FASEB J. 2019;33(9):10515–27.

Article  CAS  Google Scholar 

Jingjing W, Zhikai W, Xingyi Z, Peixuan L, Yiwu F, Xia W, et al. Lysine-specific demethylase 1 (LSD1) serves as an potential epigenetic determinant to regulate inflammatory responses in mastitis. Int Immunopharmacol. 2021;91:107324.

Article  Google Scholar 

Liu L, Sun Q, Bao R, Roth M, Zhong B, Lan X, et al. Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung inflammation. Sci Rep. 2016;6:21810.

Article  CAS  Google Scholar 

Zhong Y, Ye P, Mei Z, Huang S, Huang M, Li Y, et al. The novel methyltransferase SETD4 regulates TLR agonist-induced expression of cytokines through methylation of lysine 4 at histone 3 in macrophages. Mol Immunol. 2019;114:179–88.

Article  CAS  Google Scholar 

Laopaiboon M, Panpanich R, Swa Mya K. Azithromycin for acute lower respiratory tract infections. Cochrane Database Syst Rev. 2015;2015(3):1954.

Google Scholar 

Parnham MJ, Erakovic Haber V, Giamarellos-Bourboulis EJ, Perletti G, Verleden GM, Vos R. Azithromycin: mechanisms of action and their relevance for clinical applications. Pharmacol Ther. 2014;143(2):225–45.

Article  CAS  Google Scholar 

Khezri MR, Zolbanin NM, Ghasemnejad-Berenji M, Jafari R. Azithromycin: immunomodulatory and antiviral properties for SARS-CoV-2 infection. Eur J Pharmacol. 2021;905:174191.

Article  CAS  Google Scholar 

Tian BP, Xuan N, Wang Y, Zhang G, Cui W. The efficacy and safety of azithromycin in asthma: a systematic review. J Cell Mol Med. 2019;23(3):1638–46.

Article  CAS  Google Scholar 

Stokholm J, Chawes BL, Vissing NH, Bjarnadóttir E, Pedersen TM, Vinding RK, et al. Azithromycin for episodes with asthma-like symptoms in young children aged 1–3 years: a randomised, double-blind, placebo-controlled trial. Lancet Respir Med. 2016;4(1):19–26.

Article  CAS  Google Scholar 

Liu Y, Pu Y, Li D, Zhou L, Wan L. Azithromycin ameliorates airway remodeling via inhibiting airway epithelium apoptosis. Life Sci. 2017;170:1–8.

Article  Google Scholar 

Kang JY, Jo MR, Kang HH, Kim SK, Kim MS, Kim YH, et al. Long-term azithromycin ameliorates not only airway inflammation but also remodeling in a murine model of chronic asthma. Pulm Pharmacol Ther. 2016;36:37–45.

Article  CAS  Google Scholar 

Lecoeur H, Prina E, Rosazza T, Kokou K, N’Diaye P, Aulner N, et al. Targeting macrophage histone H3 modification as a leishmania strategy to dampen the NF-κB/NLRP3-mediated inflammatory response. Cell Rep. 2020;30(6):1870-82.e4.

Article  CAS  Google Scholar 

Chen X, Xiu M, Xing J, Yu S, Min D, Guo F. Lanthanum chloride inhibits LPS mediated expressions of pro-inflammatory cytokines and adhesion molecules in HUVECs: involvement of NF-κB-Jmjd3 signaling. Cell Physiol Biochem. 2017;42(5):1713–24.

Article  CAS  Google Scholar 

Selby A, Munro A, Grimshaw KE, Cornelius V, Keil T, Grabenhenrich L, et al. Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort. Thorax. 2018;73(11):1049–61.

Article  Google Scholar 

Picinin IF, Camargos PA, Marguet C. Cell profile of BAL fluid in children and adolescents with and without lung disease. Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. 2010;36(3):372–85.

Article  Google Scholar 

Ren Y, Liu Y, Wang S, Lei Z, Yan Y, Guan X, et al. Zhike pingchuan granules improve bronchial asthma by regulating the IL-6/JAK2/STAT3 pathway. Exp Ther Med. 2021;22(2):899.

Article  CAS  Google Scholar 

Ke W, Zhang L, Dai Y. The role of IL-6 in immunotherapy of non-small cell lung cancer (NSCLC) with immune-related adverse events (irAEs). Thorac Cancer. 2020;11(4):835–9.

Article  CAS  Google Scholar 

Fountas A, Chai ST, Ayuk J, Gittoes N, Chavda S, Karavitaki N. A rare challenging case of co-existent craniopharyngioma, acromegaly and squamous cell lung cancer. Endocrinol Diabetes Metabol Case Rep. 2018. https://doi.org/10.1530/EDM-18-0018.

Article  Google Scholar 

Song J, Lim HX, Lee A, Kim S, Lee JH, Kim TS. Staphylococcus succinus 14BME20 prevents allergic airway inflammation by induction of regulatory T cells via Interleukin-10. Front Immunol. 2019;10:1269.

Article  CAS  Google Scholar 

Gomez JL. Epigenetics in asthma. Curr Allergy Asthma Rep. 2019;19(12):56.

Article  Google Scholar 

Saradna A, Do DC, Kumar S, Fu QL, Gao P. Macrophage polarization and allergic asthma. Transl Res. 2018;191:1–14.

Article  CAS  Google Scholar 

Herviou L, Cavalli G, Moreaux J. EZH2 is therapeutic target for personalized treatment in multiple myeloma. Bull Cancer. 2018;105(9):804–19.

Article  Google Scholar 

Stokes JR, Bacharier LB. Prevention and treatment of recurrent viral-induced wheezing in the preschool child. Ann allergy Asthma Immunol. 2020;125(2):156–62.

Article  CAS  Google Scholar 

Kloepfer KM. Azithromycin may prevent severe respiratory-infection-induced wheezing. J Pediatr. 2016;172:224–7.

Article  Google Scholar 

Gannon SC, Cantley MD, Haynes DR, Hirsch R, Bartold PM. Azithromycin suppresses human osteoclast formation and activity in vitro. J Cell Physiol. 2013;228(5):1098–107.

Article  CAS  Google Scholar 

Wan YF, Huang ZH, Jing K, Li J, Wang Y, Xu CQ, et al. Azithromycin attenuates pulmonary inflammation and emphysema in smoking-induced COPD model in rats. Respir Care. 2015;60(1):128–34.

Article  Google Scholar 

Neumann C, Scheffold A, Rutz S. Functions and regulation of T cell-derived interleukin-10. Semin Immunol. 2019;44:101344.

Article  CAS  Google Scholar 

Saraiva M, Vieira P, O’Garra A. Biology and therapeutic potential of interleukin-10. J Exp Med. 2020. https://doi.org/10.1084/jem.20190418.

Article  Google Scholar 

Liu Y, Zhou N, Zhou L, Wang J, Zhou Y, Zhang T, et al. IL-2 regulates tumor-reactive CD8(+) T cell exhaustion by activating the aryl hydrocarbon receptor. Nat Immunol. 2021;22(3):358–69.

Article  CAS  Google Scholar 

Guo L, Liu MF, Huang JN, Li JM, Jiang J, Wang JA. Role of interleukin-15 in cardiovascular diseases. J Cell Mol Med. 2020;24(13):7094–101.

Article  CAS  Google Scholar 

Li M, Li R. IL-2 regulates oral mucosa inflammation through inducing endoplasmic reticulum stress and activating the NF-ĸB pathway. J Recept Signal Transduct Res. 2020;40(2):187–93.

Article