TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt

Mafi A, Rahmati A, BabaeiAghdam Z, Salami R, Salami M, Vakili O, et al. Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment. Cell Mol Biol Lett. 2022;27(1):65.

Article  CAS  Google Scholar 

Fang Y, Zhang Z. Arsenic trioxide as a novel anti-glioma drug: a review. Cell Mol Biol Lett. 2020;25:44.

Article  CAS  Google Scholar 

Datsi A, Sorg RV. Dendritic cell vaccination of glioblastoma: road to success or dead end. Front Immunol. 2021. https://doi.org/10.3389/fimmu.2021.770390.

Article  Google Scholar 

Noch EK, Ramakrishna R, Magge R. Challenges in the treatment of glioblastoma: multisystem mechanisms of therapeutic resistance. World Neurosurg. 2018;116:505–17.

Article  Google Scholar 

Yin Y, Zhong J, Li S-W, Li J-Z, Zhou M, Chen Y, et al. TRIM11, a direct target of miR-24-3p, promotes cell proliferation and inhibits apoptosis in colon cancer. Oncotarget. 2016;7(52):86755–65.

Article  Google Scholar 

Chen Y, Li L, Qian X, Ge Y, Xu G. High expression of TRIM11 correlates with poor prognosis in patients with hepatocellular carcinoma. Clin Res Hepatol Gastroenterol. 2017;41(2):190–6.

Article  CAS  Google Scholar 

Hatakeyama S. TRIM proteins and cancer. Nat Rev Cancer. 2011;11(11):792–804.

Article  CAS  Google Scholar 

Wang B, Wang G, Wang Q, Zhu Z, Wang Y, Chen K, et al. Silencing of TRIM11 suppresses the tumorigenicity of chordoma cells through improving the activity of PHLPP1/AKT. Cancer Cell Int. 2019;19(1):284.

Article  Google Scholar 

Bhaduri U, Merla G. Rise of TRIM8: a molecule of duality. Mol Ther Nucleic Acids. 2020;22:434–44.

Article  CAS  Google Scholar 

Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, et al. The tripartite motif family identifies cell compartments. Embo J. 2001;20(9):2140–51.

Article  CAS  Google Scholar 

Vincent SR, Kwasnicka DA, Fretier P. A novel RING finger-B box-coiled-coil protein, GERP. Biochem Biophys Res Commun. 2000;279(2):482–6.

Article  CAS  Google Scholar 

Di K, Linskey ME, Bota DA. TRIM11 is overexpressed in high-grade gliomas and promotes proliferation, invasion, migration and glial tumor growth. Oncogene. 2013;32(42):5038–47.

Article  CAS  Google Scholar 

Marzano F, Guerrini L, Pesole G, Sbisà E, Tullo A. Emerging roles of TRIM8 in health and disease. Cells. 2021;10(3):561.

Article  CAS  Google Scholar 

Zhang C, Mukherjee S, Tucker-Burden C, Ross JL, Chau MJ, Kong J, et al. TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3. Mol Oncol. 2017;11(3):280–94.

Article  CAS  Google Scholar 

Micale L, Fusco C, Fontana A, Barbano R, Augello B, De Nittis P, et al. TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival. BMC Cancer. 2015;15(1):470.

Article  Google Scholar 

Lathia JD, Mack SC, Mulkearns-Hubert EE, Valentim CLL, Rich JN. Cancer stem cells in glioblastoma. Genes Dev. 2015;29(12):1203–17.

Article  CAS  Google Scholar 

Alkhaibary A, Alassiri AH, AlSufiani F, Alharbi MA. Ki-67 labeling index in glioblastoma; does it really matter? Hematol Oncol Stem Cell Ther. 2019;12(2):82–8.

Article  Google Scholar 

Okumura F, Matsunaga Y, Katayama Y, Nakayama KI, Hatakeyama S. TRIM8 modulates STAT3 activity through negative regulation of PIAS3. J Cell Sci. 2010;123(13):2238–45.

Article  CAS  Google Scholar 

Hu X, Li J, Fu M, Zhao X, Wang W. The JAK/STAT signaling pathway: from bench to clinic. Signal Transduct Target Ther. 2021;6(1):402.

Article  Google Scholar 

Yagil Z, Nechushtan H, Kay G, Yang CM, Kemeny DM, Razin E. The enigma of the role of protein inhibitor of activated STAT3 (PIAS3) in the immune response. Trends Immunol. 2010;31(5):199–204.

Article  CAS  Google Scholar 

Levy C, Nechushtan H, Razin E. A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia transcription factor *. J Biol Chem. 2002;277(3):1962–6.

Article  CAS  Google Scholar 

Galoczova M, Coates P, Vojtesek B. STAT3, stem cells, cancer stem cells and p63. Cell Mol Biol Lett. 2018;23:12.

Article  Google Scholar 

Guryanova OA, Wu Q, Cheng L, Lathia JD, Huang Z, Yang J, et al. Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell. 2011;19(4):498–511.

Article  CAS  Google Scholar 

Kim E, Kim M, Woo D-H, Shin Y, Shin J, Chang N, et al. Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell. 2013;23(6):839–52.

Article  CAS  Google Scholar 

Herrmann A, Cherryholmes G, Schroeder A, Phallen J, Alizadeh D, Xin H, et al. TLR9 is critical for glioma stem cell maintenance and targeting. Can Res. 2014;74(18):5218–28.

Article  CAS  Google Scholar 

Vázquez-Arreguín K, Tantin D. The Oct1 transcription factor and epithelial malignancies: old protein learns new tricks. Biochem Biophys Acta. 2016;1859(6):792–804.

Google Scholar 

Jaworska AM, Wlodarczyk NA, Mackiewicz A, Czerwinska P. The role of TRIM family proteins in the regulation of cancer stem cell self-renewal. Stem Cells. 2020;38(2):165–73.

Article  CAS  Google Scholar 

Tomar D, Sripada L, Prajapati P, Singh R, Singh AK, Singh R. Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-κB pathway. PLoS ONE. 2012;7(11): e48662.

Article  CAS  Google Scholar 

Li Q, Yan J, Mao AP, Li C, Ran Y, Shu HB, et al. Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination. Proc Natl Acad Sci U S A. 2011;108(48):19341–6.

Article  CAS  Google Scholar 

Li Q, Yan J, Mao AP, Li C, Ran Y, Shu HB, et al. Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination. Proc Natl Acad Sci USA. 2011;108(48):19341–6.

Article  CAS  Google Scholar 

Jang HD, Yoon K, Shin YJ, Kim J, Lee SY. PIAS3 suppresses NF-κB-mediated transcription by interacting with the p65/RelA subunit *. J Biol Chem. 2004;279(23):24873–80.

Article  CAS  Google Scholar 

Liu X, Lei X, Wang J, Hong T. Identification A novel protein TRIM38 that activate NF-kappaB signaling pathways. (Zhonghua Shiyan he Linchuang Bingduxue Zazhi) Chin J Exp Clin Virol. 2011;25(1):60–2.

Google Scholar 

Wu Y-D, Zhou B. TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion. Br J Cancer. 2010;102(4):639–44.

Article  CAS  Google Scholar 

Toniato E, Chen XP, Losman J, Flati V, Donahue L, Rothman P. TRIM8/GERP RING finger protein interacts with SOCS-1 *. J Biol Chem. 2002;277(40):37315–22.

Article  CAS  Google Scholar 

Aringer M, Cheng A, Nelson JW, Chen M, Sudarshan C, Zhou YJ, et al. Janus kinases and their role in growth and disease. Life Sci. 1999;64(24):2173–86.

Article  CAS  Google Scholar 

Tamir I, Dal Porto JM, Cambier JC. Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction. Curr Opin Immunol. 2000;12(3):307–15.

Article  CAS  Google Scholar 

Croker BA, Kiu H, Nicholson SE. SOCS regulation of the JAK/STAT signalling pathway. Semin Cell Dev Biol. 2008;19(4):414–22.

Article  CAS  Google Scholar 

Liau NPD, Laktyushin A, Lucet IS, Murphy JM, Yao S, Whitlock E, et al. The molecular basis of JAK/STAT inhibition by SOCS1. Nat Commun. 2018;9(1):1558.

Article  Google Scholar 

Wang H, Lathia JD, Wu Q, Wang J, Li Z, Heddleston JM, et al. Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem Cells. 2009;27(10):2393–404.

Article  CAS  Google Scholar 

Fan X, Khaki L, Zhu TS, Soules ME, Talsma CE, Gul N, et al. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells. 2010;28(1):5–16.

Article  CAS  Google Scholar 

Banerjee K, Resat H. Constitutive activation of STAT3 in breast cancer cells: a review. Int J Cancer. 2016;138(11):2570–8.

Article  CAS  Google Scholar 

Network CGAR. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455(7216):1061.

Article  Google Scholar 

Lu S, Wang S, Geng S, Ma S, Liang Z, Jiao B. Increased expression of microRNA-17 predicts poor prognosis in human glioma. J Biomed Biotechnol. 2012;2012: 970761.

Article  Google Scholar 

Bomben R, Gobessi S, Dal Bo M, Volinia S, Marconi D, Tissino E, et al. The miR-17∼92 family regulates the response to Toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes. Leukemia. 2012;26(7):1584–93.

Article  CAS  Google Scholar 

Okumura F, Okumura AJ, Matsumoto M, Nakayama KI, Hatakeyama S. TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells. Biochim Biophys Acta. 2011;1813(10):1784–92.

Article  CAS  Google Scholar 

Setati MM, Prinsloo E, Longshaw VM, Murray PA, Edgar DH, Blatch GL. Leukemia inhibitory factor promotes Hsp90 association with STAT3 in mouse embryonic stem cells. IUBMB Life. 2010;62(1):61–6.

CAS 

留言 (0)

沒有登入
gif