World Health Organization (WHO). Obesity. 2021. https://www.who.int/news-room/facts-in-pictures/detail/6-facts-on-obesity.

World Health Organization (WHO). Obesity and overweight. 2021. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight (accessed 18 Nov 2021).

Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:6–10.

Article  CAS  Google Scholar 

Upadhyay J, Farr O, Perakakis N, Ghaly W, Mantzoros C. Obesity as a disease. Med Clin North Am. 2018;102:13–33.

Article  Google Scholar 

Blüher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15:288–98.

Article  Google Scholar 

Popkin BM, Hawkes C. Sweetening of the global diet, particularly beverages: patterns, trends, and policy responses. Lancet Diabetes Endocrinol. 2016;4:174–86.

Article  Google Scholar 

Heymsfield SB, Wadden TA. Mechanisms, pathophysiology, and management of obesity. N. Engl J Med. 2017;376:254–66.

Article  CAS  Google Scholar 

Fewtrell MS, Haschke F, Prescott SL (eds): Preventive Aspects of Early Nutrition. Nestlé Nutr Inst Workshop Ser. Nestec Ltd. Vevey/S. Karger AG Basel, 2016, vol 85, pp 155–165. https://doi.org/10.1159/000439507.

Bray MS, Loos RJ, McCaffery J. Erratum: NIH working group report-using genomic information to guide weight management: from universal to precision treatment. Obesity. 2016;24:757–757.

Article  Google Scholar 

Rohde K, Keller M, la Cour Poulsen L, Blüher M, Kovacs P, Böttcher Y. Genetics and epigenetics in obesity. Metabolism. 2019;92:37–50.

Article  CAS  Google Scholar 

Goodarzi MO. Genetics of obesity: what genetic association studies have taught us about the biology of obesity and its complications. Lancet Diabetes Endocrinol. 2018;6:223–36.

Article  CAS  Google Scholar 

Müller MJ, Geisler C, Blundell J, Dulloo A, Schutz Y, Krawczak M, et al. The case of GWAS of obesity: does body weight control play by the rules? Int J Obes. 2018;42:1395–405.

Article  Google Scholar 

Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, et al. A common genetic variant is associated with adult and childhood obesity. Science. 2006;312:279–83.

Article  CAS  Google Scholar 

Boes E, Kollerits B, Heid IM, Hunt SC, Pichler M, Paulweber B, et al. INSIG2 Polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism. Obesity. 2008;16:827–33.

Article  CAS  Google Scholar 

Hubáček J, Suchánek P, Lánská V, Piťha J, Adámková V. INSIG2 G-102A promoter variant exhibits context-dependent effect on HDL-cholesterol levels but not on BMI in Caucasians. Folia Biol. 2011;57:170–2.

Google Scholar 

Bressler J, Fornage M, Hanis CL, Kao WHL, Lewis CE, McPherson R, et al. The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts. BMC Med Genet. 2009;10. https://doi.org/10.1186/1471-2350-10-56.

Campa D, Hüsing A, McKay JD, Sinilnikova O, Vogel U, Tjønneland A, et al. The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk. BMC Cancer. 2010;10. https://doi.org/10.1186/1471-2407-10-563.

Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316:889–94.

Article  CAS  Google Scholar 

Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet. 2008;41:18–24.

Article  Google Scholar 

the GIANT Consortium. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41:25–34.

Article  Google Scholar 

Speliotes E, Willer C, Berndt S, Monda K, Thorleifsson G, Jackson A, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010;42:937–48.

Article  CAS  Google Scholar 

Locke A, Kahali B, Berndt S, Justice A, Pers T, Day F, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518:197–206.

Article  CAS  Google Scholar 

Pigeyre M, Yazdi FT, Kaur Y, Meyre D. Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity. Clin Sci. 2016;130:943–86.

Article  CAS  Google Scholar 

Fall T, Ingelsson E. Genome-wide association studies of obesity and metabolic syndrome. Mol Cell Endocrinol. 2014;382:740–57.

Article  CAS  Google Scholar 

Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, et al. Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. Nat Genet. 2017;49:1458–67.

Article  CAS  Google Scholar 

Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, et al. Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry. Hum Mol Genet. 2018;27:3641–49.

Article  CAS  Google Scholar 

Schlauch KA, Read RW, Lombardi VC, Elhanan G, Metcalf WJ, Slonim AD, et al. A comprehensive genome-wide and phenome-wide examination of BMI and obesity in a Northern Nevadan cohort. G3 Genes|Genomes|Genet. 2020;10:645–64.

Article  CAS  Google Scholar 

Chauhdary Z, Rehman K, Akash MSH. The composite alliance of FTO locus with obesity‐related genetic variants. Clin Exp Pharmacol Physiol. 2021;48:954–65.

Article  CAS  Google Scholar 

Todendi PF, de Moura Valim AR, Klinger E, Reuter CP, Molina S, Martínez JA, et al. The role of the genetic variants IRX3 rs3751723 and FTO rs9939609 in the obesity phenotypes of children and adolescents. Obes Res Clin Pract. 2019;13:137–42.

Article  Google Scholar 

Bañales-Luna M, Figueroa-Vega N, Marín-Aragón CI, Perez-Luque E, Ibarra-Reynoso L, Gallardo-Blanco HL, et al. Associations of nicotidamide-N-methyltransferase, FTO, and IRX3 genetic variants with body mass index and resting energy expenditure in Mexican subjects. Sci Rep. 2020;10. https://doi.org/10.1038/s41598-020-67832-7.

Yılmaz B, Gezmen, Karadağ M. The current review of adolescent obesity: the role of genetic factors. J Pediatr Endocrinol Metab. 2020;34:151–62.

Article  Google Scholar 

Castro GV, Latorre AFS, Korndorfer FP, de Carlos Back LK, Lofgren SE. The impact of variants in four genes: MC4R, FTO, PPARG and PPARGC1A in overweight and obesity in a large sample of the Brazilian population. Biochem Genet. 2021;59:1666–79.

Article  Google Scholar 

Yu K, Li L, Zhang L, Guo L, Wang C. Association between MC4R rs17782313 genotype and obesity: a meta-analysis. Gene. 2020;733:144372.

Article  CAS  Google Scholar 

Todendi PF, Klinger EI, Geraldo ACR, Brixner L, Reuter CP, Lindenau JDR, et al. Genetic risk score based on fat mass and obesity-associated, transmembrane protein 18 and fibronectin type III domain containing 5 polymorphisms is associated with anthropometric characteristics in South Brazilian children and adolescents. Br J Nutr. 2018;121:93–9.

Article  Google Scholar 

Velazquez-Roman J, Angulo-Zamudio UA, León-Sicairos N, Medina-Serrano J, DeLira-Bustillos N, Villamil-Ramírez H, et al. Association of FTO, ABCA1, ADRB3, and PPARG variants with obesity, type 2 diabetes, and metabolic syndrome in a Northwest Mexican adult population. J Diabetes Complicat. 2021;35:108025.

Article  CAS  Google Scholar 

Gholamalizadeh M, Mirzaei Dahka S, Vahid F, Bourbour F, Badeli M, Javadi Kooshesh S et al. Does the rs9939609 FTO gene polymorphism affect fat percentage? A meta-analysis. Arch Physiol Biochem. 2020; 128:1421–1425. https://doi.org/10.1080/13813455.2020.1773861.

Yasri S, Wiwanitkit V. Association of FTO rs9939609 with obesity. Med Princ Pract. 2018;27:496–6.

Article  Google Scholar 

Gerken T, Girard CA, Tung Y-CL, Webby CJ, Saudek V, Hewitson KS, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science. 2007;318:1469–72.

Article  CAS  Google Scholar 

Gulati P, Yeo GSH. The biology of FTO: from nucleic acid demethylase to amino acid sensor. Diabetologia. 2013;56:2113–21.

Article  CAS  Google Scholar 

Koj N, Grochowalski Ł, Jarczak J, Wójtowicz W, Sobalska-Kwapis M, Słomka M et al. The association between polymorphisms near TMEM18 and the risk of obesity: a meta-analysis. BMC Med Genom. 2021;14. https://doi.org/10.1186/s12920-021-01025-7.

Delhanty PJD, Bouw E, Huisman M, Vervenne RML, Themmen APN, van der Lely AJ, et al. Functional characterization of a new human melanocortin-4 receptor homozygous mutation (N72K) that is associated with early-onset obesity. Mol Biol Rep. 2014;41:7967–72.

Article  CAS  Google Scholar 

Dina C, Meyre D, Gallina S, Durand E, Körner A, Jacobson P, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet. 2007;39:724–6.

Article  CAS  Google Scholar 

Scuteri A, Sanna S, Chen W-M, Uda M, Albai G, Strait J, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 2007;3:e115.

Article  Google Scholar 

Egorenkova NP, Sorokina EY, Pogozheva AV, Peskova EV, Makurina ON, Levin LG, et al. The study of the peculiarities of metabolism in individuals with rs9939609 polymorphism of FTO gene. Vopr Pitan. 2015;84:97–104.

CAS  Google Scholar 

Willer CJ, Speliotes EK, Loos RJF. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2008;41:25–34.

Google Scholar 

Qi L, Kraft P, Hunter DJ, Hu FB. The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. Hum Mol Genet. 2008;17:3502–8.

Article  CAS  Google Scholar 

Magno FCCM, Guaraná HC, da Fonseca ACP, Pedrosa AP, Zembrzuski VM, Cabello PH, et al. Association of the MC4R rs17782313 polymorphism with plasma ghrelin, leptin, IL6 and TNFα concentrations, food intake and eating behaviors in morbidly obese women. Eat Weight Disord - Stud Anorex, Bulim Obes. 2020;26:1079–87.

Article  Google Scholar 

El Hajj Chehadeh S, Osman W, Nazar S, Jerman L, Alghafri A, Sajwani A, et al. Implication of genetic variants in overweight and obesity susceptibility among the young Arab population of the United Arab Emirates. Gene. 2020;739:144509.

Article  CAS  Google Scholar 

Kang J, Guan R-C, Zhao Y, Chen Y. Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients. BMC Med. Genet. 2020;21. https://doi.org/10.1186/s12881-020-00999-y.

Smemo S, Tena JJ, Kim K-H, Gamazon ER, Sakabe NJ, Gómez-Marín C, et al. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014;507:371–75.

Article  CAS  Google Scholar 

Liu C, Chu C, Zhang J, Wu D, Xu D, Li P, et al. IRX3is a genetic modifier for birth weight, adolescent obesity and transaminase metabolism. Pediatr Obes. 2017;13:141–8.

Article  Google Scholar 

Srivastava A, Mittal B, Prakash J, Srivastava P, Srivastava N, Srivastava N. A multianalytical approach to evaluate the association of 55 SNPs in 28 genes with obesity risk in North Indian adults. Am J Hum Biol. 2016;29:e22923.

Article