Ebbehoj A, Stochholm K, Jacobsen SF, Trolle C, Jepsen P, Robaczyk MG, Rasmussen ÅK, Feldt-Rasmussen U, Thomsen RW, Søndergaard E, Poulsen PL (2021) Incidence and clinical presentation of pheochromocytoma and sympathetic paraganglioma: A population-based study. J Clin Endocrinol Metab 106:e2251–e2261. https://doi.org/10.1210/clinem/dgaa965
Juhlin CC (2021) Challenges in paragangliomas and pheochromocytomas: from histology to molecular immunohistochemistry. Endocr Pathol 32:228–244. https://doi.org/10.1007/s12022-021-09675-0
Mete O, Asa SL, Gill AJ, Kimura N, de Krijger RR, Tischler A (2022) Overview of the 2022 WHO classification of paragangliomas and pheochromocytomas. Endocr Pathol 33:90–114. https://doi.org/10.1007/s12022-022-09704-6
Fishbein L (2016) Pheochromocytoma and paraganglioma: Genetics, diagnosis, and treatment. Hematol Oncol Clin North Am 30:135–150. https://doi.org/10.1016/j.hoc.2015.09.006
Powers JF, Korgaonkar PG, Fliedner S, Giubellino A, Pacak K, Sahagian GG, Tischler AS (2014) Cytocidal activities of topoisomerase 1 inhibitors and 5-azacytidine against pheochromocytoma/paraganglioma cells in primary human tumor cultures and mouse cell lines. PLoS One 9:e87807. https://doi.org/10.1371/journal.pone.0087807
Lenders JWM, Duh Q-Y, Eisenhofer G, Gimenez-Roqueplo A-P, Grebe SKG, Murad MH, Naruse M, Pacak K, Young WF (2014) Pheochromocytoma and paraganglioma: An endocrine society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism 99:1915–1942. https://doi.org/10.1210/jc.2014-1498
Juhlin CC, Mete O (2022) Advances in adrenal and extra-adrenal paraganglioma: Practical synopsis for pathologists. Adv Anat Pathol. https://doi.org/10.1097/PAP.0000000000000365
Welander J, Andreasson A, Juhlin CC, Wiseman RW, Bäckdahl M, Höög A, Larsson C, Gimm O, Söderkvist P (2014) Rare germline mutations identified by targeted next-generation sequencing of susceptibility genes in pheochromocytoma and paraganglioma. J Clin Endocrinol Metab 99:E1352–1360. https://doi.org/10.1210/jc.2013-4375
Buffet A, Burnichon N, Favier J, Gimenez-Roqueplo A-P (2020) An overview of 20 years of genetic studies in pheochromocytoma and paraganglioma. Best Pract Res Clin Endocrinol Metab 34:101416. https://doi.org/10.1016/j.beem.2020.101416
Stenman A, Zedenius J, Juhlin CC (2019) The value of histological algorithms to predict the malignancy potential of pheochromocytomas and abdominal paragangliomas-a meta-analysis and systematic review of the literature. Cancers (Basel) 11:225. https://doi.org/10.3390/cancers11020225
Wachtel H, Hutchens T, Baraban E, Schwartz LE, Montone K, Baloch Z, LiVolsi V, Krumeich L, Fraker DL, Nathanson KL, Cohen DL, Fishbein L (2020) Predicting metastatic potential in pheochromocytoma and paraganglioma: A comparison of PASS and GAPP scoring systems. J Clin Endocrinol Metab 105:e4661-4670. https://doi.org/10.1210/clinem/dgaa608
Cho YY, Kwak MK, Lee S-E, Ahn SH, Kim H, Suh S, Kim B-J, Song K-H, Koh J-M, Kim JH, Lee SH (2018) A clinical prediction model to estimate the metastatic potential of pheochromocytoma/paraganglioma: ASES score. Surgery 164:511–517. https://doi.org/10.1016/j.surg.2018.05.001
Feng F, Zhu Y, Wang X, Wu Y, Zhou W, Jin X, Zhang R, Sun F, Kasoma Z, Shen Z (2011) Predictive factors for malignant pheochromocytoma: analysis of 136 patients. J Urol 185:1583–1590. https://doi.org/10.1016/j.juro.2010.12.050
Stenman A, Svahn F, Hojjat-Farsangi M, Zedenius J, Söderkvist P, Gimm O, Larsson C, Juhlin CC (2018) Molecular profiling of pheochromocytoma and abdominal paraganglioma stratified by the PASS algorithm reveals chromogranin B as associated with histologic prediction of malignant behavior. Am J Surg Pathol. https://doi.org/10.1097/PAS.0000000000001190
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674. https://doi.org/10.1016/j.cell.2011.02.013
Toh Y-M, Li T-K (2011) Mitoxantrone inhibits HIF-1α expression in a topoisomerase II-independent pathway. Clin Cancer Res 17:5026–5037. https://doi.org/10.1158/1078-0432.CCR-11-0235
Romero A, Caldés T, Díaz-Rubio E, Martín M (2012) Topoisomerase 2 alpha: a real predictor of anthracycline efficacy? Clin Transl Oncol 14:163–168. https://doi.org/10.1007/s12094-012-0779-1
Jain M, Zhang L, He M, Zhang Y-Q, Shen M, Kebebew E (2013) TOP2A is overexpressed and is a therapeutic target for adrenocortical carcinoma. Endocr Relat Cancer 20:361–370. https://doi.org/10.1530/ERC-12-0403
Liu T, Zhang H, Yi S, Gu L, Zhou M (2019) Mutual regulation of MDM4 and TOP2A in cancer cell proliferation. Mol Oncol 13:1047–1058. https://doi.org/10.1002/1878-0261.12457
Lan J, Huang H-Y, Lee S-W, Chen T-J, Tai H-C, Hsu H-P, Chang K-Y, Li C-F (2014) TOP2A overexpression as a poor prognostic factor in patients with nasopharyngeal carcinoma. Tumour Biol 35:179–187. https://doi.org/10.1007/s13277-013-1022-6
Faggad A, Darb-Esfahani S, Wirtz R, Sinn B, Sehouli J, Könsgen D, Lage H, Weichert W, Noske A, Budczies J, Müller BM, Buckendahl A-C, Röske A, Eldin Elwali N, Dietel M, Denkert C (2009) Topoisomerase IIalpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis. Mod Pathol 22:579–588. https://doi.org/10.1038/modpathol.2009.14
Su Q, Ding Q, Zhang Z, Yang Z, Qiu Y, Li X, Mo W (2020) Identification of genes associated with the metastasis of pheochromocytoma/paraganglioma based on weighted gene coexpression network analysis. Biomed Res Int 2020:3876834. https://doi.org/10.1155/2020/3876834
Suh YJ, Park JH, Bilegsaikhan S-E, Lee DJ (2019) Transcriptome analysis reveals significant differences in gene expression of malignant pheochromocytoma or paraganglioma. Int J Endocrinol 2019:7014240. https://doi.org/10.1155/2019/7014240
Wang X, Wang J, Lyu L, Gao X, Cai Y, Tang B (2022) Oncogenic role and potential regulatory mechanism of topoisomerase IIα in a pan-cancer analysis. Sci Rep 12:11161. https://doi.org/10.1038/s41598-022-15205-7
Zhao F, Chang J, Zhao P, Wang W, Sun X, Ma X, Yin M, Wang Y, Yang Y (2022) Oncogenetic function and prognostic value of DNA topoisomerase ii alpha in human malignances: A pan-cancer analysis. Front Genet 13:856692. https://doi.org/10.3389/fgene.2022.856692
Zethoven M, Martelotto L, Pattison A, Bowen B, Balachander S, Flynn A, Rossello FJ, Hogg A, Miller JA, Frysak Z, Grimmond S, Fishbein L, Tischler AS, Gill AJ, Hicks RJ, Dahia PLM, Clifton-Bligh R, Pacak K, Tothill RW (2022) Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment. Nat Commun 13:6262. https://doi.org/10.1038/s41467-022-34011-3
Gupta D, Shidham V, Holden J, Layfield L (2000) Prognostic value of immunohistochemical expression of topoisomerase alpha II, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu in adrenal and extra-adrenal pheochromocytomas. Appl Immunohistochem Mol Morphol 8:267–274
Lloyd RV, Osamura RY, Klöppel G, Rosai J, International Agency for Research on Cancer (2017) WHO classification of tumours of endocrine organs, 4th edition. International Agency for Research on Cancer, Lyon
Stenman A, Welander J, Gustavsson I, Brunaud L, Bäckdahl M, Söderkvist P, Gimm O, Juhlin CC, Larsson C (2016) HRAS mutation prevalence and associated expression patterns in pheochromocytoma. Genes Chromosomes Cancer 55:452–459. https://doi.org/10.1002/gcc.22347
Fishbein L, Leshchiner I, Walter V, Danilova L, Robertson AG, Johnson AR, Lichtenberg TM, Murray BA, Ghayee HK, Else T, Ling S, Jefferys SR, de Cubas AA, Wenz B, Korpershoek E, Amelio AL, Makowski L, Rathmell WK, Gimenez-Roqueplo A-P, Giordano TJ, Asa SL, Tischler AS, Cancer Genome Atlas Research Network, Pacak K, Nathanson KL, Wilkerson MD (2017) Comprehensive molecular characterization of pheochromocytoma and paraganglioma. Cancer Cell 31:181–193. https://doi.org/10.1016/j.ccell.2017.01.001
Hellgren LS, Stenman A, Paulsson JO, Höög A, Larsson C, Zedenius J, Juhlin CC (2022) Prognostic utility of the Ki-67 labeling index in follicular thyroid tumors: a 20-year experience from a tertiary thyroid center. Endocr Pathol 33:231–242. https://doi.org/10.1007/s12022-022-09714-4
Kim KY, Kim JH, Hong AR, Seong M-W, Lee KE, Kim S-J, Kim SW, Shin CS, Kim SY (2016) Disentangling of malignancy from benign pheochromocytomas/paragangliomas. PLoS ONE 11:e0168413. https://doi.org/10.1371/journal.pone.0168413
Juhlin CC, Stenman A, Haglund F, Clark VE, Brown TC, Baranoski J, Bilguvar K, Goh G, Welander J, Svahn F, Rubinstein JC, Caramuta S, Yasuno K, Günel M, Bäckdahl M, Gimm O, Söderkvist P, Prasad ML, Korah R, Lifton RP, Carling T (2015) Whole-exome sequencing defines the mutational landscape of pheochromocytoma and identifies KMT2D as a recurrently mutated gene. Genes Chromosomes Cancer 54:542–554. https://doi.org/10.1002/gcc.22267
Gong M-C, Chen W-Q, Jin Z-Q, Lyu J, Meng L-H, Wu H-Y, Chen F-H (2021) Prognostic value and significant pathway exploration associated with TOP2A involved in papillary thyroid cancer. Int J Gen Med 14:3485–3496. https://doi.org/10.2147/IJGM.S316145
Chen D, Maruschke M, Hakenberg O, Zimmermann W, Stief CG, Buchner A (2017) TOP2A, HELLS, ATAD2, and TET3 are novel prognostic markers in renal cell carcinoma. Urology 102:265.e1-265.e7. https://doi.org/10.1016/j.urology.2016.12.050
Chen T, Sun Y, Ji P, Kopetz S, Zhang W (2015) Topoisomerase IIα in chromosome instability and personalized cancer therapy. Oncogene 34:4019–4031. https://doi.org/10.1038/onc.2014.332
Yu B, Chen L, Zhang W, Li Y, Zhang Y, Gao Y, Teng X, Zou L, Wang Q, Jia H, Liu X, Zheng H, Hou P, Yu H, Sun Y, Zhang Z, Zhang P, Zhang L (2020) TOP2A and CENPF are synergistic master regulators activated in cervical cancer. BMC Med Genomics 13:145. https://doi.org/10.1186/s12920-020-00800-2
Mete O, Pakbaz S, Lerario AM, Giordano TJ, Asa SL (2021) Significance of alpha-inhibin expression in pheochromocytomas and paragangliomas. Am J Surg Pathol 45:1264–1273. https://doi.org/10.1097/PAS.0000000000001715
Schovanek J, Bullova P, Tayem Y, Giubellino A, Wesley R, Lendvai N, Nölting S, Kopacek J, Frysak Z, Pommier Y, Kummar S, Pacak K (2015) Inhibitory effect of the noncamptothecin topoisomerase I inhibitor LMP-400 on female mice models and human pheochromocytoma cells. Endocrinology 156:4094–4104. https://doi.org/10.1210/en.2015-1476
Arivazhagan A, Kumar DM, Sagar V, Patric IRP, Sridevi S, Thota B, Srividya MR, Prasanna K, Thennarasu K, Mondal N, Hegde AS, Chandramouli BA, Santosh V, Rao MRS, Kondaiah P, Somasundaram K (2012) Higher topoisomerase 2 alpha gene transcript levels predict better prognosis in GBM patients receiving temozolomide chemotherapy: identification of temozolomide as a TOP2A inhibitor. J Neurooncol 107:289–297. https://doi.org/10.1007/s11060-011-0758-3
Granberg D, Juhlin CC, Falhammar H (2021) Metastatic pheochromocytomas and abdominal paragangliomas. J Clin Endocrinol Metab 106:e1937–e1952. https://doi.org/10.1210/clinem/dgaa982
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