Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression

Acharyya S, Oskarsson T, Vanharanta S et al (2012) A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell 150(1):165–178. https://doi.org/10.1016/j.cell.2012.04.042

Article  CAS  Google Scholar 

Assaf H, Azouri H, Pallardy M (2004) Ochratoxin A induces apoptosis in human lymphocytes through down regulation of Bcl-xL. Toxicol Sci 79(2):335–344. https://doi.org/10.1093/toxsci/kfh123

Article  CAS  Google Scholar 

Bai Y, Ma K, Li J, Li J, Bi C, Shan A (2021) Deoxynivalenol exposure induces liver damage in mice: inflammation and immune responses, oxidative stress, and protective effects of Lactobacillus rhamnosus GG. Food Chem Toxicol 156:112514. https://doi.org/10.1016/j.fct.2021.112514

Article  CAS  Google Scholar 

Birch J, Gil J (2020) Senescence and the SASP: many therapeutic avenues. Genes Dev 34(23–24):1565–1576. https://doi.org/10.1101/gad.343129.120

Article  CAS  Google Scholar 

Cai G, Liu S, Zhong F et al (2021) Zearalenone and deoxynivalenol inhibited IL-4 receptor-mediated Th2 cell differentiation and aggravated bacterial infection in mice. Toxicol Appl Pharmacol 415:115441. https://doi.org/10.1016/j.taap.2021.115441

Article  CAS  Google Scholar 

Calcinotto A, Alimonti A (2017) Aging tumour cells to cure cancer: “pro-senescence” therapy for cancer. Swiss Med Wkly 147:w14367. https://doi.org/10.4414/smw.2017.14367

Article  CAS  Google Scholar 

Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M, Alimonti A (2019) Cellular senescence: aging, cancer, and injury. Physiol Rev 99(2):1047–1078. https://doi.org/10.1152/physrev.00020.2018

Article  CAS  Google Scholar 

Campisi J, d’Adda di Fagagna F (2007) Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8(9):729–740. https://doi.org/10.1038/nrm2233

Article  CAS  Google Scholar 

Chao H, Ma H, Sun J et al (2022) Whole-transcriptome analysis of non-coding RNA alteration in porcine alveolar macrophage exposed to aflatoxin B1. Toxins (basel). https://doi.org/10.3390/toxins14060373

Article  Google Scholar 

Chen Y, Han S, Wang Y et al (2019) Oxidative Stress and Apoptotic Changes in Broiler Chicken Splenocytes Exposed to T-2 Toxin. Biomed Res Int 2019:5493870. https://doi.org/10.1155/2019/5493870

Article  CAS  Google Scholar 

Cohn RL, Gasek NS, Kuchel GA, Xu M (2022) The heterogeneity of cellular senescence: insights at the single-cell level. Trends Cell Biol. https://doi.org/10.1016/j.tcb.2022.04.011

Article  Google Scholar 

Coppé JP, Kauser K, Campisi J, Beauséjour CM (2006) Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem 281(40):29568–29574. https://doi.org/10.1074/jbc.M603307200

Article  CAS  Google Scholar 

Coppé JP, Patil CK, Rodier F et al (2008) Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6(12):2853–2868. https://doi.org/10.1371/journal.pbio.0060301

Article  CAS  Google Scholar 

Di Micco R, Krizhanovsky V, Baker D, d’Adda di Fagagna F (2021) Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Rev Mol Cell Biol 22(2):75–95. https://doi.org/10.1038/s41580-020-00314-w

Article  CAS  Google Scholar 

Eggert T, Wolter K, Ji J et al (2016) Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression. Cancer Cell 30(4):533–547. https://doi.org/10.1016/j.ccell.2016.09.003

Article  CAS  Google Scholar 

Fatima Z, Guo P, Huang D et al (2018) The critical role of p16/Rb pathway in the inhibition of GH3 cell cycle induced by T-2 toxin. Toxicology 400–401:28–39. https://doi.org/10.1016/j.tox.2018.03.006

Article  CAS  Google Scholar 

Friedman SL (2008) Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 88(1):125–172. https://doi.org/10.1152/physrev.00013.2007

Article  CAS  Google Scholar 

Gan F, Hou L, Xu H, Liu Y, Chen X, Huang K (2022) PCV2 infection aggravates OTA-induced immunotoxicity in vivo and in vitro. Ecotoxicol Environ Saf 235:113447. https://doi.org/10.1016/j.ecoenv.2022.113447

Article  CAS  Google Scholar 

García-Pérez E, Ryu D, Lee C, Lee HJ (2021) Ochratoxin A induces oxidative stress in HepG2 cells by impairing the gene expression of antioxidant anzymes. Toxins (basel). https://doi.org/10.3390/toxins13040271

Article  Google Scholar 

Gauthier T, Duarte-Hospital C, Vignard J et al (2020) Versicolorin A, a precursor in aflatoxins biosynthesis, is a food contaminant toxic for human intestinal cells. Environ Int 137:105568. https://doi.org/10.1016/j.envint.2020.105568

Article  CAS  Google Scholar 

González-Arias CA, Benitez-Trinidad AB, Sordo M et al (2014) Low doses of ochratoxin A induce micronucleus formation and delay DNA repair in human lymphocytes. Food Chem Toxicol 74:249–254. https://doi.org/10.1016/j.fct.2014.10.006

Article  CAS  Google Scholar 

Gorgoulis V, Adams PD, Alimonti A et al (2019) Cellular senescence: defining a path forward. Cell 179(4):813–827. https://doi.org/10.1016/j.cell.2019.10.005

Article  CAS  Google Scholar 

Guo P, Liu A, Huang D et al (2018) Brain damage and neurological symptoms induced by T-2 toxin in rat brain. Toxicol Lett 286:96–107. https://doi.org/10.1016/j.toxlet.2018.01.012

Article  CAS  Google Scholar 

Habrowska-Górczyńska DE, Kowalska K, Urbanek KA, Domińska K, Sakowicz A, Piastowska-Ciesielska AW (2019) Deoxynivalenol modulates the viability ROS production and apoptosis in prostate cancer cells. Toxins (basel). https://doi.org/10.3390/toxins11050265

Article  Google Scholar 

Hao S, Pan S, Hu J, Qian G, Gan F, Huang K (2015) Aflatoxin B1 suppressed T-Cell response to anti-pig-CD3 monoclonal antibody stimulation in primary porcine splenocytes: a role for the extracellular regulated protein kinase (ERK1/2) MAPK signaling pathway. J Agric Food Chem 63(26):6094–6101. https://doi.org/10.1021/acs.jafc.5b00433

Article  CAS  Google Scholar 

Huang FJ, Chan WH (2016) Effects of ochratoxin a on mouse oocyte maturation and fertilization, and apoptosis during fetal development. Environ Toxicol 31(6):724–735. https://doi.org/10.1002/tox.22085

Article  CAS  Google Scholar 

Huang CW, Liao WR, How CM, Yen PL, Wei CC (2021) Chronic exposure of zearalenone inhibits antioxidant defense and results in aging-related defects associated with DAF-16/FOXO in Caenorhabditis elegans. Environ Pollut 285:117233. https://doi.org/10.1016/j.envpol.2021.117233

Article  CAS  Google Scholar 

Janik E, Niemcewicz M, Podogrocki M, Ceremuga M, Stela M, Bijak M (2021) T-2 toxin-the most toxic trichothecene mycotoxin: metabolism, toxicity, and decontamination strategies. Molecules. https://doi.org/10.3390/molecules26226868

Article  Google Scholar 

Kalagatur NK, Abd Allah EF, Poda S et al (2021) Quercetin mitigates the deoxynivalenol mycotoxin induced apoptosis in SH-SY5Y cells by modulating the oxidative stress mediators. Saudi J Biol Sci 28(1):465–477. https://doi.org/10.1016/j.sjbs.2020.10.030

Article  CAS  Google Scholar 

Keblys M, Bernhoft A, Höfer CC, Morrison E, Larsen HJ, Flåøyen A (2004) The effects of the Penicillium mycotoxins citrinin, cyclopiazonic acid, ochratoxin A, patulin, penicillic acid, and roquefortine C on in vitro proliferation of porcine lymphocytes. Mycopathologia 158(3):317–324. https://doi.org/10.1007/s11046-005-5523-8

Article  Google Scholar 

Kim RJ, An SH, Gwark JY, Park HB (2021) Antioxidant effects on hypoxia-induced oxidative stress and apoptosis in rat rotator cuff fibroblasts. Eur Cell Mater 41:680–693. https://doi.org/10.22203/eCM.v041a44

Article  CAS  Google Scholar 

Kuroda K, Hibi D, Ishii Y et al (2015) Role of p53 in the progression from ochratoxin A-induced DNA damage to gene mutations in the kidneys of mice. Toxicol Sci 144(1):65–76. https://doi.org/10.1093/toxsci/kfu267

Article  CAS  Google Scholar 

Lee SY, Park KH, Lee G et al (2021) Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss. Exp Mol Med 53(4):591–604. https://doi.org/10.1038/s12276-021-00594-y

Article  CAS  Google Scholar 

Leontieva OV, Natarajan V, Demidenko ZN, Burdelya LG, Gudkov AV, Blagosklonny MV (2012) Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proc Natl Acad Sci U S A 109(33):13314–13318. https://doi.org/10.1073/pnas.1205690109

Article  CAS  Google Scholar 

Li H, Guan K, Zuo Z et al (2019) Effects of aflatoxin B(1) on the cell cycle distribution of splenocytes in chickens. J Toxicol Pathol 32(1):27–36. https://doi.org/10.1293/tox.2018-0015

Article  CAS  Google Scholar 

Liao Y, Peng Z, Chen L, Nüssler AK, Liu L, Yang W (2018) Deoxynivalenol, gut microbiota and immunotoxicity: a potential approach? Food Chem Toxicol 112:342–354. https://doi.org/10.1016/j.fct.2018.01.013

Article  CAS  Google Scholar 

Liew WP, Mohd-Redzwan S (2018) Mycotoxin: its impact on gut health and microbiota. Front Cell Infect Microbiol 8:60. https://doi.org/10.3389/fcimb.2018.00060

Article  CAS  Google Scholar 

Liu Y, Wang W (2016) Aflatoxin B1 impairs mitochondrial functions, activates ROS generation, induces apoptosis and involves Nrf2 signal pathway in primary broiler hepatocytes. Anim Sci J 87(12):1490–1500. https://doi.org/10.1111/asj.12550

Article  CAS  Google Scholar 

Long J, Hu Z, Xue H et al (2019) Vascular endothelial growth factor (VEGF) impairs the motility and immune function of human mature dendritic cells through the VEGF receptor 2-RhoA-cofilin1 pathway. Cancer Sci 110(8):2357–2367. https://doi.org/10.1111/cas.14091

Article  CAS  Google Scholar 

Luster MI, Germolec DR, Burleson GR et al (1987) Selective immunosuppression in mice of natural killer cell activity by ochratoxin A. Cancer Res 47(9):2259–2263

CAS  Google Scholar 

Meng Z, Wang L, Liao Y et al (2021) The protective effect of heme oxygenase-1 on liver injury caused by DON-induced oxidative stress and cytotoxicity. Toxins (basel). https://doi.org/10.3390/toxins13100732

Article  Google Scholar 

Otero-Albiol D, Carnero A (2021) Cellular senescence or stemness: hypoxia flips the coin. J Exp Clin Cancer Res 40(1):243. https://doi.org/10.1186/s13046-021-02035-0

Article  Google Scholar 

Paul S, Jakhar R, Bhardwaj M, Chauhan AK, Kang SC (2021) Fumonisin B1 induces poly (ADP-ribose) (PAR) polymer-mediated cell death (parthanatos) in neuroblastoma. Food Chem Toxicol 154:112326. https://doi.org/10.1016/j.fct.2021.112326

留言 (0)

沒有登入
gif