iNKT17 cells play a pathogenic role in ethinylestradiol-induced cholestatic hepatotoxicity

Allen K, Jaeschke H, Copple BL (2011) Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol 178(1):175–186. https://doi.org/10.1016/j.ajpath.2010.11.026

Article  CAS  Google Scholar 

Azuma T, Takahashi T, Kunisato A, Kitamura T, Hirai H (2003) Human CD4+ CD25+ regulatory T cells suppress NKT cell functions. Cancer Res 63(15):4516–4520

CAS  Google Scholar 

Blackstock R, Murphy JW (2004) Age-related resistance of C57BL/6 mice to Cryptococcus neoformans is dependent on maturation of NKT cells. Infect Immun 72(9):5175–5180. https://doi.org/10.1128/IAI.72.9.5175-5180.2004

Article  CAS  Google Scholar 

Bonacchi A, Romagnani P, Romanelli RG et al (2001) Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes. J Biol Chem 276(13):9945–9954. https://doi.org/10.1074/jbc.M010303200

Article  CAS  Google Scholar 

Chappell LC, Bell JL, Smith A et al (2019) Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. Lancet 394(10201):849–860. https://doi.org/10.1016/S0140-6736(19)31270-X

Article  CAS  Google Scholar 

Choi J, Selmi C, Leung PS, Kenny TP, Roskams T, Gershwin ME (2016) Chemokine and chemokine receptors in autoimmunity: the case of primary biliary cholangitis. Expert Rev Clin Immunol 12(6):661–672. https://doi.org/10.1586/1744666X.2016.1147956

Article  CAS  Google Scholar 

Chuang YH, Lian ZX, Cheng CM et al (2005) Increased levels of chemokine receptor CXCR3 and chemokines IP-10 and MIG in patients with primary biliary cirrhosis and their first degree relatives. J Autoimmun 25(2):126–132. https://doi.org/10.1016/j.jaut.2005.08.009

Article  CAS  Google Scholar 

Chuang YH, Lian ZX, Yang GX et al (2008) Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis. Hepatology 47(2):571–580. https://doi.org/10.1002/hep.22052

Article  CAS  Google Scholar 

Crosby CM, Kronenberg M (2018) Tissue-specific functions of invariant natural killer T cells. Nat Rev Immunol 18(9):559–574. https://doi.org/10.1038/s41577-018-0034-2

Article  CAS  Google Scholar 

Cui J, Shin T, Kawano T et al (1997) Requirement for valpha14 NKT cells in IL-12-mediated rejection of tumors. Science 278(5343):1623–1626. https://doi.org/10.1126/science.278.5343.1623

Article  CAS  Google Scholar 

Cui K, Yan G, Zheng X et al (2017) Suppression of natural killer cell activity by regulatory NKT10 cells aggravates alcoholic hepatosteatosis. Front Immunol 8:1414. https://doi.org/10.3389/fimmu.2017.01414

Article  CAS  Google Scholar 

De Giorgi L, Sorini C, Cosorich I, Ferrarese R, Canducci F, Falcone M (2018) Increased iNKT17 Cell frequency in the intestine of non-obese diabetic mice correlates with high bacterioidales and low clostridiales abundance. Front Immunol 9:1752. https://doi.org/10.3389/fimmu.2018.01752

Article  CAS  Google Scholar 

de Graaf KL, Lapeyre G, Guilhot F et al (2018) NI-0801, an anti-chemokine (C-X-C motif) ligand 10 antibody, in patients with primary biliary cholangitis and an incomplete response to ursodeoxycholic acid. Hepatol Commun 2(5):492–503. https://doi.org/10.1002/hep4.1170

Article  CAS  Google Scholar 

Doisne JM, Soulard V, Becourt C et al (2011) Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria. J Immunol. https://doi.org/10.4049/jimmunol.1002725

Article  Google Scholar 

Exley MA, Dellabona P, Casorati G (2021) Exploiting CD1-restricted T cells for clinical benefit. Mol Immunol 132:126–131. https://doi.org/10.1016/j.molimm.2020.12.015

Article  CAS  Google Scholar 

Floreani A, Mangini C (2018) Primary biliary cholangitis: Old and novel therapy. Eur J Intern Med 47:1–5. https://doi.org/10.1016/j.ejim.2017.06.020

Article  CAS  Google Scholar 

Hang S, Paik D, Yao L et al (2019) Bile acid metabolites control TH17 and treg cell differentiation. Nature 576(7785):143–148. https://doi.org/10.1038/s41586-019-1785-z

Article  CAS  Google Scholar 

Hao H, Cao L, Jiang C et al (2017) Farnesoid X Receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsis. Cell Metab 25(4):856–867

Article  CAS  Google Scholar 

Huh JR, Leung MW, Huang P et al (2011) Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing rorgammat activity. Nature 472(7344):486–490. https://doi.org/10.1038/nature09978

Article  CAS  Google Scholar 

Hydes TJ, Blunt MD, Naftel J et al (2019) Constitutive activation of natural killer cells in primary biliary cholangitis. Front Immunol 10:2633. https://doi.org/10.3389/fimmu.2019.02633

Article  CAS  Google Scholar 

Jia H, Chen J, Zhang X et al (2022) IL-17A produced by invariant natural killer T cells and CD3(+) CD56(+) alphaGalcer-CD1d tetramer(-) T cells promote liver fibrosis in patients with primary biliary cholangitis. J Leukoc Biol. https://doi.org/10.1002/JLB.2A0622-586RRRR

Article  Google Scholar 

Jin F, Cheng D, Tao JY et al (2013) Anti-inflammatory and anti-oxidative effects of corilagin in a rat model of acute cholestasis. BMC Gastroenterol 13:79. https://doi.org/10.1186/1471-230X-13-79

Article  CAS  Google Scholar 

Johnston B, Kim CH, Soler D, Emoto M, Butcher EC (2003) Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsets. J Immunol 171(6):2960–2969. https://doi.org/10.4049/jimmunol.171.6.2960

Article  CAS  Google Scholar 

Jordan-Williams KL, Poston S, Taparowsky EJ (2013) BATF regulates the development and function of IL-17 producing iNKT cells. BMC Immunol 14:16. https://doi.org/10.1186/1471-2172-14-16

Article  CAS  Google Scholar 

Karin N, Razon H (2018) Chemokines beyond chemo-attraction: CXCL10 and its significant role in cancer and autoimmunity. Cytokine 109:24–28. https://doi.org/10.1016/j.cyto.2018.02.012

Article  CAS  Google Scholar 

Kawaguchi M, Kokubu F, Huang SK et al (2007) The IL-17F signaling pathway is involved in the induction of IFN-gamma-inducible protein 10 in bronchial epithelial cells. J Allergy Clin Immunol 119(6):1408–1414. https://doi.org/10.1016/j.jaci.2007.02.036

Article  CAS  Google Scholar 

Khader SA, Bell GK, Pearl JE et al (2007) IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during mycobacterium tuberculosis challenge. Nat Immunol 8(4):369–377. https://doi.org/10.1038/ni1449

Article  CAS  Google Scholar 

Kim CH, Johnston B, Butcher EC (2002) Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. Blood 100(1):11–16. https://doi.org/10.1182/blood-2001-12-0196

Article  CAS  Google Scholar 

Kim ND, Moon JO, Slitt AL, Copple BL (2006) Early growth response factor-1 is critical for cholestatic liver injury. Toxicol Sci 90(2):586–595. https://doi.org/10.1093/toxsci/kfj111

Article  CAS  Google Scholar 

Kirbas A, Biberoglu E, Ersoy AO et al (2016) The role of interleukin-17 in intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med 29(6):977–981. https://doi.org/10.3109/14767058.2015.1028354

Article  CAS  Google Scholar 

Kobayashi E, Kobayashi M, Tsuneyama K, Fukami T, Nakajima M, Yokoi T (2009) Halothane-induced liver injury is mediated by interleukin-17 in mice. Toxicol Sci 111(2):302–310. https://doi.org/10.1093/toxsci/kfp165

Article  CAS  Google Scholar 

Kobayashi M, Higuchi S, Mizuno K et al (2010) Interleukin-17 is involved in alpha-naphthylisothiocyanate-induced liver injury in mice. Toxicology 275(1–3):50–57. https://doi.org/10.1016/j.tox.2010.05.011

Article  CAS  Google Scholar 

Kong X, Kong Y, Zhang F, Wang T, Zhu X (2018) Expression and significance of dendritic cells and Th17/Treg in serum and placental tissues of patients with intrahepatic cholestasis of pregnancy. J Matern Fetal Neonatal Med 31(7):901–906. https://doi.org/10.1080/14767058.2017.1300652

Article  CAS  Google Scholar 

Kontturi M, Sotaniemi E (1969) Effect of oestrogen on liver function of prostatic cancer patients. Br Med J 4(5677):204–205. https://doi.org/10.1136/bmj.4.5677.204

Article  CAS  Google Scholar 

Lee YJ, Wang H, Starrett GJ, Phuong V, Jameson SC, Hogquist KA (2015) Tissue-specific distribution of iNKT cells impacts their cytokine response. Immunity 43(3):566–578. https://doi.org/10.1016/j.immuni.2015.06.025

Article  CAS  Google Scholar 

Li X, Liu R, Luo L et al (2017a) Role of AMP-activated protein kinase alpha1 in 17alpha-ethinylestradiol-induced cholestasis in rats. Arch Toxicol 91(1):481–494. https://doi.org/10.1007/s00204-016-1697-8

Article  CAS  Google Scholar 

Li X, Liu R, Zhang L, Jiang Z (2017b) The emerging role of AMP-activated protein kinase in cholestatic liver diseases. Pharmacol Res 125(Pt B):105–113. https://doi.org/10.1016/j.phrs.2017.09.002

Article  CAS  Google Scholar 

Manousou P, Kolios G, Drygiannakis I et al (2013) CXCR3 axis in patients with primary biliary cirrhosis: a possible novel mechanism of the effect of ursodeoxycholic acid. Clin Exp Immunol 172(1):9–15. https://doi.org/10.1111/cei.12032

Article  CAS  Google Scholar 

McGinley AM, Sutton CE, Edwards SC et al (2020) Interleukin-17A serves a priming role in autoimmunity by recruiting IL-1beta-producing myeloid cells that promote pathogenic T cells. Immunity 52(2):342–356

Article  CAS  Google Scholar 

Mencarelli A, Renga B, Migliorati M et al (2009) The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis. J Immunol 183(10):6657–6666. https://doi.org/10.4049/jimmunol.0901347

Article  CAS  Google Scholar 

Monteiro M, Almeida CF, Agua-Doce A, Graca L (2013) Induced IL-17-producing invariant NKT cells require activation in presence of TGF-beta and IL-1beta. J Immunol 190(2):805–811. https://doi.org/10.4049/jimmunol.1201010

Article  CAS  Google Scholar 

Nishioji K, Okanoue T, Itoh Y et al (2001) Increase of chemokine interferon-inducible protein-10 (IP-10) in the serum of patients with autoimmune liver diseases and increase of its mRNA expression in hepatocytes. Clin Exp Immunol 123(2):271–279. https://doi.org/10.1046/j.1365-2249.2001.01391.

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