Bartek MJ, LaBudde JA, Maibach HI (1972) Skin permeability in vivo: comparison in rat, rabbit, pig and man. J Investig Dermatol 58:114–123. https://doi.org/10.1111/1523-1747.ep12538909

Article  CAS  Google Scholar 

Benschop HP, De Jong LPA (2001) Toxicokinetics of nerve agents. Vojen Zdr LISTY 11

Bester SM, Guelta MA, Cheung J et al (2018) Structural insights of stereospecific inhibition of human acetylcholinesterase by VX and subsequent reactivation by HI-6. Chem Res Toxicol 31:1405–1417. https://doi.org/10.1021/acs.chemrestox.8b00294

Article  CAS  Google Scholar 

Bjarnason S, Mikler J, Hill I et al (2008) Comparison of selected skin decontaminant products and regimens against VX in domestic swine. Hum Exp Toxicol 27:253–261. https://doi.org/10.1177/0960327108090269

Article  CAS  Google Scholar 

Black R (2016) Chapter 1—development, historical use and properties of chemical warfare agents. In: Worek F, Jenner J, Thiermann H (eds) Chemical warfare toxicology. Royal Society of Chemistry, pp 1–28

Google Scholar 

Chilcott RP, Dalton CH, Hill I et al (2005) In vivo skin absorption and distribution of the nerve agent VX (O-ethyl-S-[2(diisopropylamino)ethyl] methylphosphonothioate) in the domestic white pig. Hum Exp Toxicol 24:347–352. https://doi.org/10.1191/0960327105ht537oa

Article  CAS  Google Scholar 

Craig FN, Cummings EG, Sim VM (1977) Environmental temperature and the percutaneous absorption of a cholinesterase inhibitor, VX. J Investig Dermatol 68:357–361. https://doi.org/10.1111/1523-1747.ep12496487

Article  CAS  Google Scholar 

da Fonseca Carvalho LM (2021) Novichok(s) a challenge to the chemical weapons convention. Port J Mil Sci 9:39–62

Google Scholar 

Dorandeu F, Nachon F (2017) Des contre-mesures médicales face à la menace des neurotoxiques organophosphorés. Biofutur 2017:42–45

Google Scholar 

Dorandeu F, Mikler JR, Thiermann H et al (2007) Swine models in the design of more effective medical countermeasures against organophosphorus poisoning. Toxicology 233:128–144. https://doi.org/10.1016/j.tox.2006.09.013

Article  CAS  Google Scholar 

Duncan EJS, Brown A, Lundy P et al (2002) Site-specific percutaneous absorption of methyl salicylate and VX in domestic swine. J Appl Toxicol JAT 22:141–148. https://doi.org/10.1002/jat.838

Article  CAS  Google Scholar 

Eddleston M, Buckley NA, Eyer P, Dawson AH (2008) Management of acute organophosphorus pesticide poisoning. Lancet Lond Engl 371:597–607. https://doi.org/10.1016/S0140-6736(07)61202-1

Article  CAS  Google Scholar 

Ellman GL, Courtney KD, Andres V, Feather-Stone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95

Article  CAS  Google Scholar 

Ganesan K, Raza SK, Vijayaraghavan R (2010) Chemical warfare agents. J Pharm Bioallied Sci 2:166–178. https://doi.org/10.4103/0975-7406.68498

Article  CAS  Google Scholar 

Gupta RC (2015) Handbook of toxicology of chemical warfare agents, 2nd edn. Academic Press Elsevier, Amsterdam

Google Scholar 

Hamilton MG, Hill I, Conley J et al (2004) Clinical aspects of percutaneous poisoning by the chemical warfare agent VX: effects of application site and decontamination. Mil Med 169:856–862. https://doi.org/10.7205/milmed.169.11.856

Article  Google Scholar 

Harris L, Broomfield C, Adams N, Stitcher D (1984) Detoxification of soman and o-cyclopentyl-s-diethylaminoethyl methylphosphonothioate in vivo. Proc West Pharmacol Soc 27:315–318

CAS  Google Scholar 

Hoenig SL (2007) Compendium of chemical warfare agents. https://link.springer.com/book/10.1007/978-0-387-69260-9

Jacobi U, Kaiser M, Toll R et al (2007) Porcine ear skin: an in vitro model for human skin. Skin Res Technol 13:19–24. https://doi.org/10.1111/j.1600-0846.2006.00179.x

Article  Google Scholar 

John H, Balszuweit F, Steinritz D et al (2020) Chapter 52—toxicokinetic aspects of nerve agents and vesicants. In: Gupta RC (ed) Handbook of toxicology of chemical warfare agents, 3rd edn. Academic Press, Boston, pp 875–919

Chapter  Google Scholar 

Langenberg JP, van Dijk C, Sweeney RE et al (1997) Development of a physiologically based model for the toxicokinetics of C(+/−)P(+/−)-soman in the atropinized guinea pig. Arch Toxicol 71:320–331. https://doi.org/10.1007/s002040050393

Article  CAS  Google Scholar 

Lockridge O (2015) Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses. Pharmacol Ther 148:34–46. https://doi.org/10.1016/j.pharmthera.2014.11.011

Article  CAS  Google Scholar 

Mann TM, Price ME, Whitmore CL et al (2018) Bioscavenger is effective as a delayed therapeutic intervention following percutaneous VX poisoning in the guinea-pig. Toxicol Lett 293:198–206. https://doi.org/10.1016/j.toxlet.2017.11.029

Article  CAS  Google Scholar 

Marrs TC, Maynard RL, Sidell FR (2007) Chemical warfare agents: toxicology and treatment, 2nd edn. Wiley, New York

Book  Google Scholar 

Mikler J, Tenn C, Worek F et al (2011) Immobilization of Russian VX skin depots by localized cooling: implications for decontamination and medical countermeasures. Toxicol Lett 206:47–53. https://doi.org/10.1016/j.toxlet.2011.05.1047

Article  CAS  Google Scholar 

Mumford H, Docx CJ, Price ME et al (2013) Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning. Chem Biol Interact 203:160–166. https://doi.org/10.1016/j.cbi.2012.08.018

Article  CAS  Google Scholar 

Munro NB, Talmage SS, Griffin GD et al (1999) The sources, fate, and toxicity of chemical warfare agent degradation products. Environ Health Perspect 107:933–974. https://doi.org/10.1289/ehp.99107933

Article  CAS  Google Scholar 

Reiter G, Mikler J, Hill I et al (2008) Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples. J Chromatogr B Anal Technol Biomed Life Sci 873:86–94. https://doi.org/10.1016/j.jchromb.2008.08.001

Article  CAS  Google Scholar 

Reiter G, Mikler J, Hill I et al (2011) Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies. J Chromatogr B Anal Technol Biomed Life Sci 879:2704–2713. https://doi.org/10.1016/j.jchromb.2011.07.031

Article  CAS  Google Scholar 

Reiter G, Müller S, Hill I et al (2015) In vitro and in vivo toxicological studies of V nerve agents: molecular and stereoselective aspects. Toxicol Lett 232:438–448. https://doi.org/10.1016/j.toxlet.2014.11.010

Article  CAS  Google Scholar 

Reutter SA, Mioduszewski RJ, Thomson SA (2000) Evaluation of airborne exposure limits for VX: worker and general population exposure criteria. ECBC-TR-074. https://www.federalregister.gov/documents/2002/01/08/02-396/airborne-exposure-limits-for-chemical-warfare-agents-ga-tabun-gb-sarin-and-vx

Rolland P, Bolzinger M-A, Cruz C et al (2011) Human scalp permeability to the chemical warfare agent VX. Toxicol Vitro Int J Publ Assoc BIBRA 25:1974–1980. https://doi.org/10.1016/j.tiv.2011.06.021

Article  CAS  Google Scholar 

Sawyer TW, Mikler J, Worek F et al (2011) The therapeutic use of localized cooling in the treatment of VX poisoning. Toxicol Lett 204:52–56. https://doi.org/10.1016/j.toxlet.2011.04.008

Article  CAS  Google Scholar 

Silva GR, Borges I Jr, Figueroa-Villar JD, de Castro AT (2012) Defesa química: histórico, classificação dos agentes de guerra e ação dos neurotóxicos. Quím Nova 35:2083–2091. https://doi.org/10.1590/S0100-40422012001000033

Article  CAS  Google Scholar 

Steindl D, Boehmerle W, Körner R et al (2021) Novichok nerve agent poisoning. Lancet Lond Engl 397:249–252. https://doi.org/10.1016/S0140-6736(20)32644-1

Article  CAS  Google Scholar 

Taylor P, Radic Z, Hosea NA et al (1995) Structural bases for the specificity of cholinesterase catalysis and inhibition. Toxicol Lett 82–83:453–458. https://doi.org/10.1016/0378-4274(95)03575-3

Article  Google Scholar 

Vale JA, Marrs TC, Maynard RL (2018) Novichok: a murderous nerve agent attack in the UK. Clin Toxicol Phila Pa 56:1093–1097. https://doi.org/10.1080/15563650.2018.1469759

Article  CAS  Google Scholar 

Vallet V, Cruz C, Licausi J et al (2008) Percutaneous penetration and distribution of VX using in vitro pig or human excised skin validation of demeton-S-methyl as adequate simulant for VX skin permeation investigations. Toxicology 246:73–82. https://doi.org/10.1016/j.tox.2007.12.027

Article  CAS  Google Scholar 

van der Schans MJ, Lander BJ, van der Wiel H et al (2003) Toxicokinetics of the nerve agent (+/−)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration. Toxicol Appl Pharmacol 191:48–62. https://doi.org/10.1016/s0041-008x(03)00216-3

Article  Google Scholar 

Worek F, Mast U, Kiderlen D et al (1999) Improved determination of acetylcholinesterase activity in human whole blood. Clin Chim Acta Int J Clin Chem 288:73–90. https://doi.org/10.1016/s0009-8981(99)00144-8

Article  CAS  Google Scholar