Proactive therapeutic drug monitoring of vincristine in pediatric and adult cancer patients: current supporting evidence and future efforts

Agu L, Skiles JL, Masters AR, Renbarger JL, Chow DS (2021) Simultaneous quantification of vincristine and its major M1 metabolite from dried blood spot samples of Kenyan pediatric cancer patients by UPLC-MS/MS. J Pharm Biomed Anal 203:114143. https://doi.org/10.1016/j.jpba.2021.114143

Article  CAS  Google Scholar 

Anghelescu DL, Faughnan LG, Jeha S, Relling MV, Hinds PS, Sandlund JT, Cheng C, Pei D, Hankins G, Pauley JL et al (2011) Neuropathic pain during treatment for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 57:1147–1153. https://doi.org/10.1002/pbc.23039

Article  Google Scholar 

Barnett S, Hellmann F, Parke E, Makin G, Tweddle DA, Osborne C, Hempel G, Veal GJ (2022) Vincristine dosing, drug exposure and therapeutic drug monitoring in neonate and infant cancer patients. Eur J Cancer 164:127–136. https://doi.org/10.1016/j.ejca.2021.09.014

Article  CAS  Google Scholar 

Bedikian AY, Vardeleon A, Smith T, Campbell S, Namdari R (2006) Pharmacokinetics and urinary excretion of vincristine sulfate liposomes injection in metastatic melanoma patients. J Clin Pharmacol 46:727–737. https://doi.org/10.1177/0091270006288953

Article  CAS  Google Scholar 

Bedikian AY, Silverman JA, Papadopoulos NE, Kim KB, Hagey AE, Vardeleon A, Hwu WJ, Homsi J, Davies M, Hwu P (2011) Pharmacokinetics and safety of Marqibo (vincristine sulfate liposomes injection) in cancer patients with impaired liver function. J Clin Pharmacol 51:1205–1212. https://doi.org/10.1177/0091270010381499

Article  CAS  Google Scholar 

Behan JW, Avramis VI, Yun JP, Louie SG, Mittelman SD (2010) Diet-induced obesity alters vincristine pharmacokinetics in blood and tissues of mice. Pharmacol Res 61:385–390. https://doi.org/10.1016/j.phrs.2010.01.007

Article  CAS  Google Scholar 

Bender RA, Castle MC, Margileth DA, Oliverio VT (1977) The pharmacokinetics of [3H]-vincristine in man. Clin Pharmacol Ther 22:430–435. https://doi.org/10.1002/cpt1977224430

Article  CAS  Google Scholar 

Beumer JH, Chu E, Allegra C, Tanigawara Y, Milano G, Diasio R, Kim TW, Mathijssen RH, Zhang L, Arnold D et al (2019) Therapeutic drug monitoring in oncology: international association of therapeutic drug monitoring and clinical toxicology recommendations for 5-fluorouracil therapy. Clin Pharmacol Ther 105:598–613. https://doi.org/10.1002/cpt.1124

Article  Google Scholar 

Bosilkovska M, Ing Lorenzini K, Uppugunduri CR, Desmeules J, Daali Y, Escher M (2016) Severe vincristine-induced neuropathic pain in a CYP3A5 nonexpressor with reduced CYP3A4/5 activity: case study. Clin Ther 38:216–220. https://doi.org/10.1016/j.clinthera.2015.10.017

Article  CAS  Google Scholar 

Broyl A, Corthals SL, Jongen JLM, van der Holt B, Kuiper R, de Knegt Y, van Duin M, el Jarari L, Bertsch U, Lokhorst HM et al (2010) Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol 11:1057–1065. https://doi.org/10.1016/s1470-2045(10)70206-0

Article  CAS  Google Scholar 

Carozzi VA, Canta A, Chiorazzi A (2015) Chemotherapy-induced peripheral neuropathy: What do we know about mechanisms? Neurosci Lett 596:90–107. https://doi.org/10.1016/j.neulet.2014.10.014

Article  CAS  Google Scholar 

Cavaletti G, Bogliun G, Marzorati L, Zincone A, Piatti M, Colombo N, Franchi D, La Presa MT, Lissoni A, Buda A et al (2004) Early predictors of peripheral neurotoxicity in cisplatin and paclitaxel combination chemotherapy. Ann Oncol 15:1439–1442. https://doi.org/10.1093/annonc/mdh348

Article  CAS  Google Scholar 

Cavaletti G, Frigeni B, Lanzani F, Piatti M, Rota S, Briani C, Zara G, Plasmati R, Pastorelli F, Caraceni A et al (2007) The Total Neuropathy Score as an assessment tool for grading the course of chemotherapy-induced peripheral neurotoxicity: comparison with the national cancer institute-common toxicity scale. J Peripher Nerv Syst 12:210–215. https://doi.org/10.1111/j.1529-8027.2007.00141.x

Article  Google Scholar 

Ceppi F, Langlois-Pelletier C, Gagne V, Rousseau J, Ciolino C, De Lorenzo S, Kevin KM, Cijov D, Sallan SE, Silverman LB et al (2014) Polymorphisms of the vincristine pathway and response to treatment in children with childhood acute lymphoblastic leukemia. Pharmacogenomics 15:1105–1116. https://doi.org/10.2217/pgs.14.68

Article  CAS  Google Scholar 

Chan A, Hertz DL, Morales M, Adams EJ, Gordon S, Tan CJ, Staff NP, Kamath J, Oh J, Shinde S et al (2019) Biological predictors of chemotherapy-induced peripheral neuropathy (CIPN): MASCC neurological complications working group overview. Support Care Cancer 27:3729–3737. https://doi.org/10.1007/s00520-019-04987-8

Article  Google Scholar 

Clarke WA, Chatelut E, Fotoohi AK, Larson RA, Martin JH, Mathijssen RHJ, Salamone SJ (2021) Therapeutic drug monitoring in oncology: international association of therapeutic drug monitoring and clinical toxicology consensus guidelines for imatinib therapy. Eur J Cancer 157:428–440. https://doi.org/10.1016/j.ejca.2021.08.033

Article  CAS  Google Scholar 

Crom WR, de Graaf SS, Synold T, Uges DR, Bloemhof H, Rivera G, Christensen ML, Mahmoud H, Evans WE (1994) Pharmacokinetics of vincristine in children and adolescents with acute lymphocytic leukemia. J Pediatr 125:642–649. https://doi.org/10.1016/s0022-3476(94)70027-3

Article  CAS  Google Scholar 

Damen CW, Rosing H, Tibben MM, van Maanen MJ, Lagas JS, Schinkel AH, Schellens JH, Beijnen JH (2008) A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 868:102–109. https://doi.org/10.1016/j.jchromb.2008.04.046

Article  CAS  Google Scholar 

Damen CW, Rosing H, Schellens JH, Beijnen JH (2009) Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D. Anal Bioanal Chem 394:1171–1182. https://doi.org/10.1007/s00216-009-2775-z

Article  CAS  Google Scholar 

de Graaf SS, Bloemhof H, Vendrig DE, Uges DR (1995) Vincristine disposition in children with acute lymphoblastic leukemia. Med Pediatr Oncol 24:235–240. https://doi.org/10.1002/mpo.2950240405

Article  Google Scholar 

Deitcher OR, Glaspy J, Gonzalez R, Sato T, Bedikian AY, Segarini K, Silverman J, Deitcher SR (2014) High-dose vincristine sulfate liposome injection (Marqibo) Is not associated with clinically meaningful hematologic toxicity. Clin Lymphoma Myeloma Leuk 14:197–202. https://doi.org/10.1016/j.clml.2013.10.012

Article  Google Scholar 

Dennison JB, Kulanthaivel P, Barbuch RJ, Renbarger JL, Ehlhardt WJ, Hall SD (2006) Selective metabolism of vincristine in vitro by CYP3A5. Drug Metab Dispos 34:1317–1327. https://doi.org/10.1124/dmd.106.009902

Article  CAS  Google Scholar 

Dennison JB, Jones DR, Renbarger JL, Hall SD (2007) Effect of CYP3A5 expression on vincristine metabolism with human liver microsomes. J Pharmacol Exp Ther 321:553–563. https://doi.org/10.1124/jpet.106.118471

Article  CAS  Google Scholar 

Dennison JB, Renbarger JL, Walterhouse DO, Jones DR, Hall SD (2008) Quantification of vincristine and its major metabolite in human plasma by high-performance liquid chromatography/tandem mass spectrometry. Ther Drug Monit 30:357–364. https://doi.org/10.1097/FTD.0b013e31816b92c9

Article  CAS  Google Scholar 

Desai ZR, Berg, H.W.V.d., Bridges, J.M., and Shanks, R.G. (1982) Can severe vincristine neurotoxicity be prevented? Cancer Chemother Pharmacol 8:211–214. https://doi.org/10.1007/BF00255486

Article  CAS  Google Scholar 

Diouf B, Crews KR, Lew G, Pei D, Cheng C, Bao J, Zheng JJ, Yang W, Fan Y, Wheeler HE et al (2015) Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia. JAMA 313:815–823. https://doi.org/10.1001/jama.2015.0894

Article  CAS  Google Scholar 

Douer D (2016) Efficacy and safety of vincristine sulfate liposome injection in the treatment of adult acute lymphocytic leukemia. Oncologist 21:840–847. https://doi.org/10.1634/theoncologist.2015-0391

Article  CAS  Google Scholar 

Egbelakin A, Ferguson MJ, MacGill EA, Lehmann AS, Topletz AR, Quinney SK, Li L, McCammack KC, Hall SD, Renbarger JL (2011) Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia. Pediatr Blood Cancer 56:361–367. https://doi.org/10.1002/pbc.22845

Article  Google Scholar 

Embree L, Gelmon KA, Tolcher AW, Hudon NJ, Heggie JR, Dedhar C, Webb MS, Bally MB, Mayer LD (1997) Validation of a high-performance liquid chromatographic assay method for quantification of total vincristine sulfate in human plasma following administration of vincristine sulfate liposome injection. J Pharm Biomed Anal 16:675–687. https://doi.org/10.1016/s0731-7085(97)00087-3

Article  CAS  Google Scholar 

Embree L, Gelmon K, Tolcher A, Hudon N, Heggie J, Dedhar C, Logan P, Bally MB, Mayer LD (1998) Pharmacokinetic behavior of vincristine sulfate following administration of vincristine sulfate liposome injection. Cancer Chemother Pharmacol 41:347–352. https://doi.org/10.1007/s002800050750

Article  CAS  Google Scholar 

Frigeni B, Piatti M, Lanzani F, Alberti P, Villa P, Zanna C, Ceracchi M, Ildebrando M, Cavaletti G (2011) Chemotherapy-induced peripheral neurotoxicity can be misdiagnosed by the national cancer institute common toxicity scale. J Peripher Nerv Syst 16:228–236. https://doi.org/10.1111/j.1529-8027.2011.00351.x

Article  Google Scholar 

Frost BM, Lönnerholm G, Koopmans P, Abrahamsson J, Behrendtz M, Castor A, Forestier E, Uges DR, de Graaf SS (2003) Vincristine in childhood leukaemia: no pharmacokinetic rationale for dose reduction in adolescents. Acta paediatrica (Oslo, Norway : 1992) 92, 551–557.

Gidding CE, Meeuwsen-de Boer GJ, Koopmans P, Uges DR, Kamps WA, de Graaf SS (1999) Vincristine pharmacokinetics after repetitive dosing in children. Cancer Chemother Pharmacol 44:203–209. https://doi.org/10.1007/s002800050968

Article  CAS  Google Scholar 

Gilchrist LS, Tanner L (2013) The pediatric-modified total neuropathy score: a reliable and valid measure of chemotherapy-induced peripheral neuropathy in children with non-CNS cancers. Support Care Cancer 21:847–856. https://doi.org/10.1007/s00520-012-1591-8

Article  Google Scholar 

Gilchrist LS, Marais L, Tanner L (2014) Comparison of two chemotherapy-induced peripheral neuropathy measurement approaches in children. Support Care Cancer 22:359–366. https://doi.org/10.1007/s00520-013-1981-6

Article  CAS  Google Scholar 

Gomber S, Dewan P, Chhonker D (2010) Vincristine induced neurotoxicity in cancer patients. Indian J Pediatr 77:97–100. https://doi.org/10.1007/s12098-009-0254-3

Article  Google Scholar 

Groninger E, Meeuwsen-de Boar T, Koopmans P, Uges D, Sluiter W, Veerman A, Kamps W, de Graaf S (2002) Pharmacokinetics of vincristine monotherapy in childhood acute lymphoblastic leukemia. Pediatr Res 52:113–118. https://doi.org/10.1203/00006450-200207000-00021

Article  CAS  Google Scholar 

Groninger E, Meeuwsen-de Boer T, Koopmans P, Uges D, Sluiter W, Veerman A, Kamps W, de Graaf S (2005) Vincristine pharmacokinetics and response to vincristine monotherapy in an up-front window study of the Dutch Childhood Leukaemia Study Group (DCLSG). Eur J Cancer 41:98–103. https://doi.org/10.1016/j.ejca.2004.10.006

Article  CAS  Google Scholar 

Guilhaumou R, Simon N, Quaranta S, Verschuur A, Lacarelle B, Andre N, Solas C (2011) Population pharmacokinetics and pharmacogenetics of vincristine in paediatric patients treated for solid tumour diseases. Cancer Chemother Pharmacol 68:1191–1198. https://doi.org/10.1007/s00280-010-1541-4

Article  CAS  Google Scholar 

Gutierrez-Camino A, Umerez M, Martin-Guerrero I, Garcia de Andoin N, Santos B, Sastre A, Echebar

留言 (0)

沒有登入
gif