Singer, M., C.S. Deutschman, C.W. Seymour, et al. 2016. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315: 801–810.
Iwashyna, T.J., C.R. Cooke, H. Wunsch, and J.M. Kahn. 2012. Population burden of long-term survivorship after severe sepsis in older Americans. Journal of the American Geriatrics Society 60: 1070–1077.
Cecconi, M., L. Evans, M. Levy, and A. Rhodes. 2018. Sepsis and septic shock. Lancet 392: 75–87.
Iwashyna, T.J., E.W. Ely, D.M. Smith, and K.M. Langa. 2010. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 304: 1787–1794.
Strnad, P., F. Tacke, A. Koch, and C. Trautwein. 2017. Liver - guardian, modifier and target of sepsis. Nature Reviews. Gastroenterology & Hepatology 14: 55–66.
Yan, J., and S. Li. 2014. The role of the liver in sepsis. International Reviews of Immunology 33: 498–510.
Brun-Buisson, C., P. Meshaka, P. Pinton, and B. Vallet. 2004. EPISEPSIS: A reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Medicine 30: 580–588.
Terkeltaub, R.A., D.E. Furst, K. Bennett, K.A. Kook, R.S. Crockett, and M.W. Davis. 2010. High versus low dosing of oral colchicine for early acute gout flare: Twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study. Arthritis and rheumatism 62: 1060–1068.
Dinarello C.A, S.M. Wolff S.E. Goldfinger D.C. Dale and Alling D.W. 1974. Colchicine therapy for familial mediterranean fever. A double-blind trial. The New England journal of medicine 291: 934–937.
Imazio, M., A. Brucato, R. Cemin, et al. 2013. A randomized trial of colchicine for acute pericarditis. The New England journal of medicine 369: 1522–1528.
Tardif, J.C., S. Kouz, D.D. Waters, et al. 2019. Efficacy and safety of low-dose colchicine after myocardial infarction. New England Journal of Medicine 381: 2497–2505.
Forkosh, E., A. Kenig, and Y. Ilan. 2020. Introducing variability in targeting the microtubules: Review of current mechanisms and future directions in colchicine therapy. Pharmacology Research & Perspectives 8: e00616.
Li, Z., G.S. Davis, C. Mohr, M. Nain, and D. Gemsa. 1996. Inhibition of LPS-induced tumor necrosis factor-alpha production by colchicine and other microtubule disrupting drugs. Immunobiology 195: 624–639.
Schattner A., I. el-Hador T. Hahn, and Landau Z. 1997. Triple anti-TNF-alpha therapy in early sepsis: a preliminary report. Journal of International Medical Research 25: 112–116.
Fang, F., Y. Zhang, J. Tang, et al. 2019. Association of corticosteroid treatment with outcomes in adult patients with sepsis: A systematic review and meta-analysis. JAMA Internal Medicine 179: 213–223.
Ilan, Y. 2016. Oral immune therapy: Targeting the systemic immune system via the gut immune system for the treatment of inflammatory bowel disease. Clin Transl Immunology 5: e60.
Ilan, Y. 2016. Review article: Novel methods for the treatment of non-alcoholic steatohepatitis - targeting the gut immune system to decrease the systemic inflammatory response without immune suppression. Alimentary Pharmacology & Therapeutics 44: 1168–1182.
Ilan, Y. 2019. Immune rebalancing by oral immunotherapy: A novel method for getting the immune system back on track. Journal of Leukocyte Biology 105: 463–472.
Ilan, Y., K. Shailubhai, and A. Sanyal. 2018. Immunotherapy with oral administration of humanized anti-CD3 monoclonal antibody: A novel gut-immune system-based therapy for metaflammation and NASH. Clinical and Experimental Immunology 193: 275–283.
Drori, A., D. Rotnemer-Golinkin, S. Avni, et al. 2017. Attenuating the rate of total body fat accumulation and alleviating liver damage by oral administration of vitamin D-enriched edible mushrooms in a diet-induced obesity murine model is mediated by an anti-inflammatory paradigm shift. BMC Gastroenterology 17: 130.
Almon, E., T. Khoury, A. Drori, et al. 2017. An oral administration of a recombinant anti-TNF fusion protein is biologically active in the gut promoting regulatory T cells: Results of a phase I clinical trial using a novel oral anti-TNF alpha-based therapy. Journal of Immunological Methods 446: 21–29.
Ilan, Y., A. Ben Ya’acov, Y. Shabbat, S. Gingis-Velitski, E. Almon, and Y. Shaaltiel. 2016. Oral administration of a non-absorbable plant cell-expressed recombinant anti-TNF fusion protein induces immunomodulatory effects and alleviates nonalcoholic steatohepatitis. World Journal of Gastroenterology 22: 8760–8769.
Ben Ya’acov, A., Y. Lichtenstein, L. Zolotarov, and Y. Ilan. 2015. The gut microbiome as a target for regulatory T cell-based immunotherapy: Induction of regulatory lymphocytes by oral administration of anti-LPS enriched colostrum alleviates immune mediated colitis. BMC Gastroenterology 15: 154.
Khoury, T., A. Ben Ya’acov, Y. Shabat, L. Zolotarovya, R. Snir, and Y. Ilan. 2015. Altered distribution of regulatory lymphocytes by oral administration of soy-extracts exerts a hepatoprotective effect alleviating immune mediated liver injury, non-alcoholic steatohepatitis and insulin resistance. World Journal of Gastroenterology 21: 7443–7456.
Ilan, Y. 2009. Oral tolerance: Can we make it work? Human Immunology 70: 768–776.
Elinav, E., O. Pappo, M. Sklair-Levy, et al. 2006. Amelioration of non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice by oral immune regulation towards liver-extracted proteins is associated with elevated intrahepatic NKT lymphocytes and serum IL-10 levels. The Journal of Pathology 208: 74–81.
Ilan, Y., M. Margalit, M. Ohana, et al. 2005. Alleviation of chronic GVHD in mice by oral immuneregulation toward recipient pretransplant splenocytes does not jeopardize the graft versus leukemia effect. Human Immunology 66: 231–240.
Margalit, M., and Y. Ilan. 2004. Oral immune regulation: A novel method for modulation of anti-viral immunity. Journal of Clinical Virology 31 (Suppl 1): S63–S68.
Shibolet, O., R. Alper, L. Zlotogarov, et al. 2004. Suppression of hepatocellular carcinoma growth via oral immune regulation towards tumor-associated antigens is associated with increased NKT and CD8+ lymphocytes. Oncology 66: 323–330.
Nagler, A., M. Pines, U. Abadi, et al. 2000. Oral tolerization ameliorates liver disorders associated with chronic graft versus host disease in mice. Hepatology 31: 641–648.
Trop, S., D. Samsonov I. Gotsman R. Alper J. Diment and Ilan Y. 1999. Liver-associated lymphocytes expressing NK1.1 are essential for oral immune tolerance induction in a murine model. Hepatology 29: 746–755.
Ilan, Y., B. Sauter, N.R. Chowdhury, et al. 1998. Oral tolerization to adenoviral proteins permits repeated adenovirus-mediated gene therapy in rats with pre-existing immunity to adenoviruses. Hepatology 27: 1368–1376.
Lalazar, G., E. Zigmond, S. Weksler-Zangen, et al. 2017. Oral administration of beta-glucosylceramide for the treatment of insulin resistance and nonalcoholic steatohepatitis: Results of a double-blind, placebo-controlled trial. Journal of Medicinal Food 20: 458–464.
Lalazar, G., M. Mizrahi, I. Turgeman, et al. 2015. Oral Administration of OKT3 MAb to Patients with NASH, promotes regulatory T-cell induction, and alleviates insulin resistance: Results of a phase IIa blinded placebo-controlled trial. Journal of Clinical Immunology 35: 399–407.
Israeli, E., E. Zigmond, G. Lalazar, et al. 2015. Oral mixture of autologous colon-extracted proteins for the Crohn’s disease: A double-blind trial. World Journal of Gastroenterology 21: 5685–5694.
Israeli, E., E. Goldin, S. Fishman, et al. 2015. Oral administration of non-absorbable delayed release 6-mercaptopurine is locally active in the gut, exerts a systemic immune effect and alleviates Crohn’s disease with low rate of side effects: Results of double blind Phase II clinical trial. Clinical and Experimental Immunology 181: 362–372.
Halota, W., P. Ferenci, D. Kozielewicz, et al. 2015. Oral anti-CD3 immunotherapy for HCV-nonresponders is safe, promotes regulatory T cells and decreases viral load and liver enzyme levels: Results of a phase-2a placebo-controlled trial. Journal of Viral Hepatitis 22: 651–657.
Mizrahi, M., Y. Shabat, A. Ben Ya’acov, et al. 2012. Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: Results of a phase I/II clinical trial in NASH. Journal of Inflammation Research 5: 141–150.
Israeli, E., and Y. Ilan. 2010. Oral administration of Alequel, a mixture of autologous colon-extracted proteins for the treatment of Crohn’s disease. Therap Adv Gastroenterol 3: 23–30.
Margalit, M., E. Israeli, O. Shibolet, et al. 2006. A double-blind clinical trial for treatment of Crohn’s disease by oral administration of Alequel, a mixture of autologous colon-extracted proteins: A patient-tailored approach. American Journal of Gastroenterology 101: 561–568.
Israeli, E., E. Goldin, O. Shibolet, et al. 2005. Oral immune regulation using colitis extracted proteins for treatment of Crohn’s disease: Results of a phase I clinical trial. World Journal of Gastroenterology 11: 3105–3111.
Shrum, B., R.V. Anantha, S.X. Xu, et al. 2014. A robust scoring system to evaluate sepsis severity in an animal model. BMC Research Notes 7: 233.
Kleiner, D.E., E.M. Brunt, M. Van Natta, et al. 2005. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41: 1313–1321.
Koskinas, J., I.P. Gomatos, D.G. Tiniakos, et al. 2008. Liver histology in ICU patients dying from sepsis: A clinico-pathological study. World Journal of Gastroenterology 14: 1389–1393.
Zhang, T., L. Yu-Jing, and T. Ma. 2022. The immunomodulatory function of adenosine in sepsis. Frontiers in Immunology 13: 936547.
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