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Real world study of sacituzumab govitecan in metastatic triple-negative breast cancer in the United Kingdom
Real world study of sacituzumab govitecan in metastatic triple-negative breast cancer in the United Kingdom
Treatment options for pre-treated patients with metastatic triple-negative breast cancer (mTNBC) remain limited. This is t...
Randomized trials of estrogen-alone and breast cancer incidence: a meta-analysis
Randomized trials of estrogen-alone and breast cancer incidence: a meta-analysis
In the Women’s Health initiative (WHI) randomized clinical trial, conjugated equine estrogen (CEE)-alone significant...
Disentangling the relationships of body mass index and circulating sex hormone concentrations in mammographic density using Mendelian randomization
Disentangling the relationships of body mass index and circulating sex hormone concentrations in mammographic density using Mendelian randomization
Mammographic density phenotypes, adjusted for age and body mass index (BMI), are strong predictors of breast cancer risk. ...
Characteristics and risk factors of axillary lymph node metastasis of microinvasive breast cancer
Characteristics and risk factors of axillary lymph node metastasis of microinvasive breast cancer
To select patients who would benefit most from sentinel lymph node biopsy (SLNB) by investigating the characteristics and ...
A New Guaianolide-type Sesquiterpenoid and Xanthine Oxidase Inhibitory Activity from Chrysanthemum sinense Flowers
A New Guaianolide-type Sesquiterpenoid and Xanthine Oxidase Inhibitory Activity from Chrysanthemum sinense Flowers
The ethanol extract of Chrysanthemum sinense Sabine, Asteraceae, flowers was found to inhibit xanthine oxidase with a IC50...
Proline Peptide Bond Isomerization in Ubiquitin under Folding and Denaturing Conditions by Pressure-Jump NMR
Proline Peptide Bond Isomerization in Ubiquitin under Folding and Denaturing Conditions by Pressure-Jump NMR
One important aspect of protein folding concerns the role of proline cis/trans isomerization because the high energetic ba...
Beyond the C-terminal glycine of ATG8 proteins – The story of some neglected amino acids
Beyond the C-terminal glycine of ATG8 proteins – The story of some neglected amino acids
Author links open overlay panel, , , Highlights•The majority of ATG8 proteins are expressed with C-terminal amino acids sh...
GMMA can stabilize proteins across different functional constraints
GMMA can stabilize proteins across different functional constraints
Improving the stability of a protein without impacting its desired function is a fundamental objective for protein enginee...
Structural basis for the interaction of Redβ single strand annealing protein with Escherichia coli single-stranded DNA binding protein
Structural basis for the interaction of Redβ single strand annealing protein with Escherichia coli single-stranded DNA binding protein
Redβ is a 261-amino acid (Mr 29.6 kDa) protein from bacteriophage λ that binds to single-stranded DNA (ssDNA) to promote t...
Effect of S-region mutations on HBsAg in HBsAg-negative HBV-infected patients
Effect of S-region mutations on HBsAg in HBsAg-negative HBV-infected patients
Occult HBV infection (OBI) is a special form of hepatitis B virus (HBV) infection that may cause Liver cirrhosis and hepat...
A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients
A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients
This study sought to examine the impact of magnesium supplementation on clinical outcomes and biochemical factors among ho...
Nonlinear relationship between viral load and TCT in single/multiple HPV52 infection
Nonlinear relationship between viral load and TCT in single/multiple HPV52 infection
To determine the correlation between HPV (human papillomavirus) 52 viral load, multiple infections and ThinPrep cytology t...
Resistance to African swine fever virus among African domestic pigs appears to be associated with a distinct polymorphic signature in the RelA gene and upregulation of RelA transcription
Resistance to African swine fever virus among African domestic pigs appears to be associated with a distinct polymorphic signature in the RelA gene and upregulation of RelA transcription
African swine fever virus (ASFV) is a highly contagious and fatal hemorrhagic disease of domestic pigs, which poses a majo...
Associations of per- and polyfluoroalkyl substances with maternal early second trimester sex-steroid hormones
Associations of per- and polyfluoroalkyl substances with maternal early second trimester sex-steroid hormones
Pregnancy is a physiologically dynamic period characterized by changes in sex-steroid hormone concentrations, including pr...
Liver stiffness measurements predict Sinusoidal Obstructive Syndrome after hematopoietic stem cell transplantation
Liver stiffness measurements predict Sinusoidal Obstructive Syndrome after hematopoietic stem cell transplantation
Sinusoidal Obstructive Syndrome (SOS) is a life-threatening complication after hematopoietic stem-cell transplantation (HS...
Acute kidney injury during autologous stem cell transplantation in light chain amyloidosis with kidney involvement and their impact on prognosis
Acute kidney injury during autologous stem cell transplantation in light chain amyloidosis with kidney involvement and their impact on prognosis
Acute kidney injury (AKI) is a complication related to important organ dysfunction during autologous stem cell transplanta...
The impact of emotional states on bilingual language control in cued and voluntary switching contexts
The impact of emotional states on bilingual language control in cued and voluntary switching contexts
A bilingual’s two languages may always be active, even when only one is required (Thierry & Wu, 2007). This process mi...
Comparing generative and extractive approaches to information extraction from abstracts describing randomized clinical trials
Comparing generative and extractive approaches to information extraction from abstracts describing randomized clinical trials
Systematic reviews of Randomized Controlled Trials (RCTs) are an important part of the evidence-based medicine paradigm. H...
Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK
Systematic Literature Review on the Incidence of Herpes Zoster in Populations at Increased Risk of Disease in the EU/EEA, Switzerland, and the UK
Older adults and patients with underlying conditions such as immunocompromised (IC) populations (e.g., due to medical cond...
Burden of Antimicrobial Resistance in Japan: A Systematic Literature Review and Meta-Analysis
Burden of Antimicrobial Resistance in Japan: A Systematic Literature Review and Meta-Analysis
Antimicrobial resistance (AMR) is one of the most serious public health challenges worldwide, including in Japan. However,...
The Impact of Video-Based Microinterventions on Attitudes Toward Mental Health and Help Seeking in Youth: Web-Based Randomized Controlled Trial
The Impact of Video-Based Microinterventions on Attitudes Toward Mental Health and Help Seeking in Youth: Web-Based Randomized Controlled Trial
Background: Mental health (MH) problems in youth are prevalent, burdening, and frequently persistent. Despite the existenc...
Behavior Change Approaches in Digital Technology–Based Physical Rehabilitation Interventions Following Stroke: Scoping Review
Behavior Change Approaches in Digital Technology–Based Physical Rehabilitation Interventions Following Stroke: Scoping Review
Background: Digital health technologies (DHTs) are increasingly used in physical stroke rehabilitation to support individu...
Factor Analysis of Patients Who Find Tablets or Capsules Difficult to Swallow Due to Their Large Size: Using the Personal Health Record Infrastructure of Electronic Medication Notebooks
Factor Analysis of Patients Who Find Tablets or Capsules Difficult to Swallow Due to Their Large Size: Using the Personal Health Record Infrastructure of Electronic Medication Notebooks
Background: Understanding patient preference regarding taking tablet or capsule formulations plays a pivotal role in treat...
The Costs of Anonymization: Case Study Using Clinical Data
The Costs of Anonymization: Case Study Using Clinical Data
Background: Sharing data from clinical studies can accelerate scientific progress, improve transparency, and increase the ...
Large Language Models and User Trust: Consequence of Self-Referential Learning Loop and the Deskilling of Health Care Professionals
Large Language Models and User Trust: Consequence of Self-Referential Learning Loop and the Deskilling of Health Care Professionals
As the health care industry increasingly embraces large language models (LLMs), understanding the consequence of this inte...
Validity of muscle activation estimated with predicted ground reaction force in inverse dynamics based musculoskeletal simulation during gait
Validity of muscle activation estimated with predicted ground reaction force in inverse dynamics based musculoskeletal simulation during gait
Musculoskeletal modeling is used to simulate neuromuscular control in various human movements (Delp and Loan, 2000, Dembia...
A hybrid statistical morphometry free-form deformation approach to 3D personalized foot-ankle models
A hybrid statistical morphometry free-form deformation approach to 3D personalized foot-ankle models
The foot contains 26 bones, which are interconnected by 33 joints, and supported by a network of more than 100 muscles, te...
The effect of time normalization and biomechanical signal processing techniques of ground reaction force curves on deep-learning model performance
The effect of time normalization and biomechanical signal processing techniques of ground reaction force curves on deep-learning model performance
Available online 24 April 2024, 112116Author links open overlay panel, Highlights•Filtering data decreased F1-score by 4%–...
Effects of different step lengths at a preferred walking speed on forefoot, midfoot, and hindfoot motion in healthy young adults
Effects of different step lengths at a preferred walking speed on forefoot, midfoot, and hindfoot motion in healthy young adults
It is important to maintain walking abilities in all individuals, especially those who are aging or have disabilities, as ...
Chemistry and light: an adventure into probing, understanding and controlling events at the molecular scale
Chemistry and light: an adventure into probing, understanding and controlling events at the molecular scale
The guest editors are very grateful to all authors for their contributions, which will appeal not only to Fred Brouwer him...
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