Search for lipidized PrRP analogs with strong anorexigenic effect: In vitro and in vivo studies

Keywords

Prolactin-releasing peptide

Lipidization

GPR10

NPFF-R2

NPFF-R1

ERK

Akt activation

Stability

Food intake

AbbreviationsANOVA

Analysis of variance

CREB

cAMP response element-binding protein

EC50

Effective concentrations

FRET

Fluorescence-resonance energy transfer

GABA

Gamma-aminobutyric acid

gWAT

Gonadal white adipose tissue

ICV

Intracerebroventricular

iWAT

Inguinal white adipose tissue

LC–MS

Liquid chromatography–mass spectrometry

MAPK/ERK

Mitogen-activated protein kinase/Extracellular signal-regulated kinase

NPFF-R1

Neuropeptide FF receptor type 1

NPFF-R2

Neuropeptide FF receptor type 2

PheCl2

Dichlorophenylalanine

PrRP

Prolactin-releasing peptide

pWAT

Perirenal white adipose tissue

SAR

Structure-activity relationship

TTDS

1,13-diamino-4,7,10-trioxatridecan-succinamic acid

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