Peripheral Nerve Involvement at First Diagnosis of Multiple Sclerosis: A Prospective MR Neurography Study

From the Departments of ∗Neuroradiology

†Neurology, Heidelberg University Hospital, Heidelberg, Germany.

Received for publication June 12, 2022; and accepted for publication, after revision, July 14, 2022.

Conflicts of interest and sources of funding: O.F. was supported by the Rahel Goitein-Straus research grant and the Physician-Scientist fellowship of the Medical Faculty of the University of Heidelberg. S.H. (SFB 1118), D.S. (SFB 1118), M.B. (SFB 1158), and B.W. were supported by the German Research Foundation. J.H. received a research grant, personal fees, lecture honoraria and financial support for conference attendance from Alnylam Pharmaceuticals. B.W. received grants from the German Ministry of Education and Research, Dietmar Hopp Foundation, Klaus Tschira Foundation; grants and personal fees from Merck; and personal fees from Alexion, Bayer, Biogen, and Teva, none related to this work. W.W. reports to be inventor and patent-holder on “Peptides for use in treating or diagnosing IDH1R132H positive cancers” (EP2800580B1) and “Cancer therapy with an oncolytic virus combined with a checkpoint inhibitor” (US11027013B2). He consulted for Apogenix, Astra Zeneca, Bayer, Enterome, MSD, and Roche/Genentech with honoraria paid to the Medical Faculty at the University of Heidelberg. L.B.J. and G.S. have nothing to disclose.

Statement on study participants in previous studies: The cohort of patients have not been included in previous investigations.

The control cohort of healthy volunteers have been partly published in the following publications: 20 of 30 subjects in Kollmer J, Weiler M, Sam G, et al. Quantitative magnetic resonance neurographic characterization of peripheral nerve involvement in manifest and pre-ataxic spinocerebellar ataxia type 3 [published online ahead of print February 28, 2022]. Eur J Neurol. doi: 10.1111/ene.15305. 20 of 30 subjects in Rother C, Bumb JM, Weiler M, et al. Characterization and quantification of alcohol-related polyneuropathy by magnetic resonance neurography. Eur J Neurol. 2022;29(2):573-582. doi: 10.1111/ene.15127.

28 of 30 subjects in Kollmer J, Hilgenfeld T, Ziegler A, et al. Quantitative MR neurography biomarkers in 5q-linked spinal muscular atrophy. Neurology. 2019;93(7):e653-e664. doi: 10.1212/WNL.0000000000007945.

Correspondence to: Olivia Foesleitner, MD, PhD, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. E-mail: [email protected].

Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.investigativeradiology.com).

留言 (0)

沒有登入
gif